Motif ID: Srf

Z-value: 1.399


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_465561880.195.2e-01Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_34861200 14.789 ENSMUST00000165033.1
Egr1
early growth response 1
chr7_-_142661305 5.915 ENSMUST00000105936.1
Igf2
insulin-like growth factor 2
chr2_+_156775409 2.971 ENSMUST00000088552.6
Myl9
myosin, light polypeptide 9, regulatory
chr7_-_19310035 2.569 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr12_+_85473883 2.493 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr10_+_79988584 2.478 ENSMUST00000004784.4
ENSMUST00000105374.1
Cnn2

calponin 2

chr7_-_142661858 2.257 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr7_-_44997221 1.736 ENSMUST00000152341.1
Bcl2l12
BCL2-like 12 (proline rich)
chrX_+_101449078 1.488 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr10_-_120899067 1.205 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_+_127336152 1.171 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr10_+_67537861 1.139 ENSMUST00000048289.7
ENSMUST00000105438.2
ENSMUST00000130933.1
ENSMUST00000146986.1
Egr2



early growth response 2



chr3_-_57575907 1.113 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr1_+_74391479 0.956 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr7_+_101896817 0.920 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr2_+_154548888 0.838 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr1_-_43163891 0.833 ENSMUST00000008280.7
Fhl2
four and a half LIM domains 2
chr7_-_44997535 0.799 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12

BCL2-like 12 (proline rich)

chr4_+_101986626 0.797 ENSMUST00000106914.1
Gm12789
predicted gene 12789
chr6_-_132314757 0.784 ENSMUST00000048686.8
Prpmp5
proline-rich protein MP5
chr14_+_20929416 0.758 ENSMUST00000022369.7
Vcl
vinculin
chr11_-_120731944 0.753 ENSMUST00000154565.1
ENSMUST00000026148.2
Cbr2

carbonyl reductase 2

chr6_-_23248264 0.751 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_+_101896340 0.678 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr1_+_167618246 0.669 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr9_-_58313189 0.604 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr2_-_13271419 0.592 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr11_+_120348678 0.582 ENSMUST00000143813.1
0610009L18Rik
RIKEN cDNA 0610009L18 gene
chr7_+_128246953 0.547 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr19_-_5912771 0.504 ENSMUST00000118623.1
Dpf2
D4, zinc and double PHD fingers family 2
chr12_-_32953772 0.472 ENSMUST00000180391.1
ENSMUST00000181670.1
4933406C10Rik

RIKEN cDNA 4933406C10 gene

chr2_+_164833781 0.467 ENSMUST00000143780.1
Ctsa
cathepsin A
chr2_-_13271268 0.465 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr5_-_145191511 0.453 ENSMUST00000161845.1
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr8_-_71381907 0.452 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr11_-_70669283 0.447 ENSMUST00000129434.1
ENSMUST00000018431.6
Spag7

sperm associated antigen 7

chr7_+_128246812 0.437 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr19_+_53529100 0.418 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr17_-_27204357 0.418 ENSMUST00000055117.7
Lemd2
LEM domain containing 2
chr16_-_4880284 0.399 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr11_-_69662625 0.398 ENSMUST00000018905.5
Mpdu1
mannose-P-dolichol utilization defect 1
chr13_+_64432479 0.393 ENSMUST00000021939.6
Cdk20
cyclin-dependent kinase 20
chr11_-_69662564 0.363 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr14_+_5501674 0.363 ENSMUST00000181562.1
Gm3488
predicted gene, 3488
chr1_-_127677923 0.356 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr19_-_5912834 0.352 ENSMUST00000136983.1
Dpf2
D4, zinc and double PHD fingers family 2
chr3_+_106113229 0.351 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr7_+_44997648 0.351 ENSMUST00000003284.8
ENSMUST00000107835.1
Irf3

interferon regulatory factor 3

chr4_+_132351768 0.328 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr14_+_4726775 0.324 ENSMUST00000165619.1
Gm3252
predicted gene 3252
chr2_+_20737306 0.323 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr2_+_164833841 0.307 ENSMUST00000152721.1
Ctsa
cathepsin A
chr1_-_131097535 0.299 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr13_+_23746734 0.295 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr8_-_47675130 0.258 ENSMUST00000080353.2
Ing2
inhibitor of growth family, member 2
chr14_-_6889962 0.235 ENSMUST00000171906.1
Gm3667
predicted gene 3667
chr14_+_3810074 0.225 ENSMUST00000170480.1
Gm3002
predicted gene 3002
chr10_+_45335751 0.203 ENSMUST00000095715.3
Bves
blood vessel epicardial substance
chr11_-_101424519 0.192 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
Gm27029

Ptges3l

predicted gene, 27029

prostaglandin E synthase 3 (cytosolic)-like

chr6_+_113378113 0.187 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr3_-_95891938 0.182 ENSMUST00000036360.6
ENSMUST00000090476.3
BC028528

cDNA sequence BC028528

chr15_-_77842133 0.176 ENSMUST00000016771.6
Myh9
myosin, heavy polypeptide 9, non-muscle
chr10_-_111997204 0.161 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr15_-_99820072 0.146 ENSMUST00000109024.2
Lima1
LIM domain and actin binding 1
chr3_-_152266320 0.142 ENSMUST00000046045.8
Nexn
nexilin
chr5_-_138996087 0.141 ENSMUST00000110897.1
Pdgfa
platelet derived growth factor, alpha
chr2_-_152415044 0.128 ENSMUST00000099207.3
Zcchc3
zinc finger, CCHC domain containing 3
chr1_+_63176818 0.126 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr14_-_45530118 0.113 ENSMUST00000045905.6
Fermt2
fermitin family homolog 2 (Drosophila)
chr18_+_80253274 0.109 ENSMUST00000131780.1
ENSMUST00000157056.1
Pqlc1

PQ loop repeat containing 1

chr4_-_43025792 0.107 ENSMUST00000067481.5
Pigo
phosphatidylinositol glycan anchor biosynthesis, class O
chr17_-_46556158 0.101 ENSMUST00000015749.5
Srf
serum response factor
chr14_+_3332627 0.091 ENSMUST00000177786.1
Gm2956
predicted gene 2956
chr14_+_4415448 0.082 ENSMUST00000168866.1
Gm3164
predicted gene 3164
chr14_-_6108665 0.076 ENSMUST00000165193.1
Gm3468
predicted gene 3468
chr14_+_74732384 0.073 ENSMUST00000176957.1
Esd
esterase D/formylglutathione hydrolase
chr2_-_164833438 0.065 ENSMUST00000042775.4
Neurl2
neuralized-like 2 (Drosophila)
chr4_-_155056784 0.056 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr11_-_70688097 0.056 ENSMUST00000108544.1
Camta2
calmodulin binding transcription activator 2
chr14_-_5880382 0.053 ENSMUST00000164484.1
Gm8237
predicted gene 8237
chr11_-_70687917 0.044 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr14_+_3652030 0.041 ENSMUST00000167430.1
Gm3020
predicted gene 3020
chr11_-_120348475 0.030 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1

actin, gamma, cytoplasmic 1

chr9_+_75051977 0.030 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr2_+_143915273 0.029 ENSMUST00000103172.3
Dstn
destrin
chr14_-_34502663 0.027 ENSMUST00000049005.8
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr13_+_51846673 0.025 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr4_+_43957678 0.014 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.8 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
1.0 8.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 2.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.3 0.8 GO:0006116 NADH oxidation(GO:0006116)
0.2 1.2 GO:0030091 protein repair(GO:0030091)
0.2 1.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.2 1.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 2.5 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.1 1.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 2.5 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.8 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.1 0.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.4 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 0.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.1 GO:0035793 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.1 1.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 2.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 2.9 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.6 GO:0001706 endoderm formation(GO:0001706)
0.0 0.5 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.1 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.1 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.1 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.0 1.0 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.1 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.4 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 GO:0016460 myosin II complex(GO:0016460)
0.1 0.8 GO:0005916 fascia adherens(GO:0005916)
0.1 1.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 8.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 3.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 0.6 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.2 0.8 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.2 1.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 2.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0070878 primary miRNA binding(GO:0070878)
0.0 2.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.4 GO:0005178 integrin binding(GO:0005178)
0.0 2.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.1 GO:0048407 platelet-derived growth factor receptor binding(GO:0005161) platelet-derived growth factor binding(GO:0048407)