Motif ID: Fli1

Z-value: 0.665


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.342.3e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 150 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478182 3.754 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 3.396 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr8_+_23035116 2.424 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr9_+_118478851 2.416 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr8_+_23035099 2.085 ENSMUST00000117662.1
 Ank1
ankyrin 1, erythroid
chr15_-_76521902 1.580 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr12_+_86678685 1.321 ENSMUST00000021681.3
 Vash1
vasohibin 1
chr11_+_32000496 1.321 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr13_-_51203065 1.041 ENSMUST00000091708.4
 Hist1h2al
histone cluster 1, H2al
chr11_-_68927049 0.980 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr11_+_32000452 0.970 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr7_-_4445595 0.874 ENSMUST00000119485.1
 Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr4_+_43406435 0.844 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 0.777 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr17_-_35703971 0.694 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr6_-_77979515 0.614 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr6_-_77979652 0.533 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chrX_-_72656135 0.498 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr8_+_106870827 0.488 ENSMUST00000176144.1
ENSMUST00000175987.1
 Has3

hyaluronan synthase 3

chr1_+_182763961 0.478 ENSMUST00000153348.1
 Susd4
sushi domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 9.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 4.5 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
0.1 2.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.5 1.5 GO:0009644 response to high light intensity(GO:0009644)
0.3 1.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 1.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 1.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 0.5 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.5 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0 0.5 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 0.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.4 GO:2000587 regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.4 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.4 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.3 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0044308 axonal spine(GO:0044308)
0.1 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.0 GO:0034455 t-UTP complex(GO:0034455)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 2.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.5 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 1.3 GO:0045296 cadherin binding(GO:0045296)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)