Motif ID: Trp73

Z-value: 0.713


Transcription factors associated with Trp73:

Gene SymbolEntrez IDGene Name
Trp73 ENSMUSG00000029026.10 Trp73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_1540971730.039.1e-01Click!


Activity profile for motif Trp73.

activity profile for motif Trp73


Sorted Z-values histogram for motif Trp73

Sorted Z-values for motif Trp73



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp73

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_153665274 2.241 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr2_-_164857542 1.584 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr9_-_58158498 1.393 ENSMUST00000168864.2
 Islr
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_164857671 1.245 ENSMUST00000059954.7
 Pltp
phospholipid transfer protein
chr1_+_135729147 1.195 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr9_-_58313189 1.148 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr7_-_116038734 0.891 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr7_-_31054815 0.742 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr4_+_119232896 0.623 ENSMUST00000121111.2
ENSMUST00000030393.6
ENSMUST00000102662.4
 Lepre1


leprecan 1


chr12_-_45074112 0.569 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr10_+_110745433 0.537 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr11_-_103344651 0.534 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr11_-_102230091 0.503 ENSMUST00000008999.5
 Hdac5
histone deacetylase 5
chr15_+_84232030 0.491 ENSMUST00000023072.6
 Parvb
parvin, beta
chr13_+_12702362 0.460 ENSMUST00000104944.2
 Gm2399
predicted gene 2399
chr10_+_127642975 0.451 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr11_-_102230127 0.420 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
 Hdac5



histone deacetylase 5



chr3_+_159839729 0.412 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr7_-_141443314 0.406 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr11_-_69948145 0.395 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr3_+_14641722 0.390 ENSMUST00000029071.8
 Car13
carbonic anhydrase 13
chr10_-_127311740 0.390 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr8_+_27085520 0.384 ENSMUST00000178514.1
ENSMUST00000033876.7
 Gpr124

G protein-coupled receptor 124

chr19_-_50030735 0.375 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr12_-_45074457 0.359 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr8_+_27085835 0.350 ENSMUST00000165366.2
 Gpr124
G protein-coupled receptor 124
chr4_+_101068983 0.337 ENSMUST00000038463.8
ENSMUST00000106955.1
 Raver2

ribonucleoprotein, PTB-binding 2

chr12_-_84876479 0.313 ENSMUST00000163189.1
ENSMUST00000110254.2
ENSMUST00000002073.6
 Ltbp2


latent transforming growth factor beta binding protein 2


chr3_-_89402650 0.303 ENSMUST00000168325.1
ENSMUST00000057431.5
 Lenep

lens epithelial protein

chr11_+_69913888 0.285 ENSMUST00000072581.2
ENSMUST00000116358.1
 Gps2

G protein pathway suppressor 2

chr11_+_114851507 0.271 ENSMUST00000177952.1
 Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr3_-_107931579 0.265 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
 Gstm7



glutathione S-transferase, mu 7



chr10_+_41810528 0.259 ENSMUST00000099931.3
 Sesn1
sestrin 1
chrX_-_109013389 0.241 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr6_+_83054653 0.237 ENSMUST00000092618.6
 Aup1
ancient ubiquitous protein 1
chr11_+_70639118 0.220 ENSMUST00000055184.6
ENSMUST00000108551.2
 Gp1ba

glycoprotein 1b, alpha polypeptide

chr4_-_45489794 0.208 ENSMUST00000146236.1
 Shb
src homology 2 domain-containing transforming protein B
chr5_-_30960326 0.207 ENSMUST00000074840.5
 Preb
prolactin regulatory element binding
chrX_+_10717390 0.205 ENSMUST00000115524.1
ENSMUST00000008179.6
 Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr9_-_44713196 0.204 ENSMUST00000144251.1
ENSMUST00000156918.1
 Phldb1

pleckstrin homology-like domain, family B, member 1

chr12_+_109747903 0.193 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr16_-_17125106 0.191 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr11_+_57801575 0.189 ENSMUST00000020826.5
 Sap30l
SAP30-like
chr15_+_78428564 0.181 ENSMUST00000166142.2
ENSMUST00000162517.1
ENSMUST00000089414.4
 Kctd17


potassium channel tetramerisation domain containing 17


chr2_-_90904827 0.172 ENSMUST00000005647.3
 Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr7_+_140881898 0.169 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr4_-_11386757 0.169 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr17_+_33940660 0.169 ENSMUST00000025170.9
 Wdr46
WD repeat domain 46
chr11_-_95699143 0.163 ENSMUST00000062249.2
 Gm9796
predicted gene 9796
chr10_-_105841323 0.154 ENSMUST00000046638.9
 Mettl25
methyltransferase like 25
chr4_+_129820198 0.149 ENSMUST00000030578.7
 Ptp4a2
protein tyrosine phosphatase 4a2
chr3_-_89245159 0.144 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr1_+_72824482 0.140 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_5070281 0.134 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr10_+_105841064 0.133 ENSMUST00000020049.8
 Ccdc59
coiled-coil domain containing 59
chrX_-_10216918 0.126 ENSMUST00000072393.2
ENSMUST00000044598.6
ENSMUST00000073392.4
ENSMUST00000115533.1
ENSMUST00000115532.1
 Rpgr




retinitis pigmentosa GTPase regulator




chr1_+_55088132 0.124 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr11_+_60931998 0.118 ENSMUST00000019076.3
 Map2k3
mitogen-activated protein kinase kinase 3
chr14_-_73325773 0.112 ENSMUST00000022701.6
 Rb1
retinoblastoma 1
chr9_-_109082372 0.095 ENSMUST00000167504.1
 Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr4_+_62583568 0.094 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr11_+_114851142 0.083 ENSMUST00000133245.1
ENSMUST00000122967.2
 Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr5_-_30960236 0.078 ENSMUST00000088063.2
 Preb
prolactin regulatory element binding
chr6_+_29398920 0.072 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr4_+_74251928 0.065 ENSMUST00000030102.5
 Kdm4c
lysine (K)-specific demethylase 4C
chrX_+_10717451 0.061 ENSMUST00000156321.1
 Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr15_+_76696725 0.060 ENSMUST00000023203.4
 Gpt
glutamic pyruvic transaminase, soluble
chr17_+_28232723 0.056 ENSMUST00000002320.8
 Ppard
peroxisome proliferator activator receptor delta
chr11_-_100738153 0.053 ENSMUST00000155500.1
ENSMUST00000107364.1
ENSMUST00000019317.5
 Rab5c


RAB5C, member RAS oncogene family


chr7_+_25282179 0.049 ENSMUST00000163320.1
ENSMUST00000005578.6
 Cic

capicua homolog (Drosophila)

chr2_-_180920925 0.042 ENSMUST00000037299.8
ENSMUST00000108876.2
 Ythdf1

YTH domain family 1

chr11_-_20831009 0.035 ENSMUST00000047028.8
 Lgalsl
lectin, galactoside binding-like
chr7_+_140882430 0.026 ENSMUST00000164681.1
ENSMUST00000163610.1
 Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr9_+_108662098 0.022 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr10_-_62651194 0.020 ENSMUST00000020270.4
 Ddx50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr3_+_89245952 0.010 ENSMUST00000040888.5
 Krtcap2
keratinocyte associated protein 2
chr7_-_65371210 0.010 ENSMUST00000102592.3
 Tjp1
tight junction protein 1
chr15_-_98607611 0.005 ENSMUST00000096224.4
 Adcy6
adenylate cyclase 6
chr11_+_98026918 0.002 ENSMUST00000017548.6
 Rpl19
ribosomal protein L19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0042360 vitamin E metabolic process(GO:0042360)
0.2 0.7 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.2 0.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 2.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 0.5 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.1 0.9 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.9 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.3 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.3 GO:0043206 extracellular fibril organization(GO:0043206)
0.0 0.2 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.4 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 1.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776) positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.1 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.4 GO:0006730 one-carbon metabolic process(GO:0006730)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.9 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0043912 D-lysine oxidase activity(GO:0043912)
0.1 0.9 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.4 GO:0005118 sevenless binding(GO:0005118)
0.1 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 2.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)