Motif ID: Rad21_Smc3

Z-value: 1.327

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rad21mm10_v2_chr15_-_51991679_51991760-0.234.3e-01Click!
Smc3mm10_v2_chr19_+_53600377_53600435-0.107.2e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_17574268 5.982 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr8_-_110168204 4.662 ENSMUST00000003754.6
 Calb2
calbindin 2
chr7_-_19698383 4.573 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr7_-_19698206 4.434 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr9_-_42944479 4.304 ENSMUST00000114865.1
 Grik4
glutamate receptor, ionotropic, kainate 4
chr7_+_35119285 4.118 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr3_+_90612869 3.167 ENSMUST00000001051.4
 S100a6
S100 calcium binding protein A6 (calcyclin)
chr12_+_70825492 2.824 ENSMUST00000057859.7
 Frmd6
FERM domain containing 6
chr7_+_25686994 2.679 ENSMUST00000002678.9
 Tgfb1
transforming growth factor, beta 1
chr10_-_31445921 2.582 ENSMUST00000000305.5
 Tpd52l1
tumor protein D52-like 1
chr2_+_157914618 2.571 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr2_-_158146385 2.324 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr8_-_122432924 2.227 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr19_-_12501996 2.219 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr12_-_84876479 2.201 ENSMUST00000163189.1
ENSMUST00000110254.2
ENSMUST00000002073.6
 Ltbp2


latent transforming growth factor beta binding protein 2


chr2_+_26586607 2.180 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
 Egfl7


EGF-like domain 7


chr3_-_84155762 2.048 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr9_+_71215779 1.972 ENSMUST00000034723.5
 Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr4_+_122995944 1.935 ENSMUST00000106252.2
 Mycl
v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived (avian)
chr13_+_117602439 1.927 ENSMUST00000006991.7
 Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 9.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.7 4.9 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.6 4.8 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 4.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 4.1 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
1.2 3.5 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1 3.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 3.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 3.3 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.5 2.8 GO:0003383 apical constriction(GO:0003383)
0.9 2.7 GO:0002295 T-helper cell lineage commitment(GO:0002295) evasion or tolerance of host defenses by virus(GO:0019049) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) positive regulation of mononuclear cell migration(GO:0071677) negative regulation of hyaluronan biosynthetic process(GO:1900126) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.8 2.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.7 2.2 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.2 2.2 GO:0043206 extracellular fibril organization(GO:0043206)
0.0 2.2 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.7 2.1 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 2.1 GO:0006310 DNA recombination(GO:0006310)
0.7 2.0 GO:0035799 ureter maturation(GO:0035799)
0.6 1.9 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.5 1.9 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 9.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 7.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 6.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.7 5.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 4.7 GO:0005921 gap junction(GO:0005921)
0.7 4.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 3.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.0 GO:0005902 microvillus(GO:0005902)
0.0 2.4 GO:0005844 polysome(GO:0005844)
0.6 2.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 2.2 GO:0001726 ruffle(GO:0001726)
0.1 2.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 2.1 GO:0043296 apical junction complex(GO:0043296)
0.0 1.8 GO:0005769 early endosome(GO:0005769)
0.1 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 1.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 1.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 9.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.5 5.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 4.4 GO:0005525 GTP binding(GO:0005525)
0.3 4.1 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 3.5 GO:0004454 ketohexokinase activity(GO:0004454)
0.0 3.4 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 3.2 GO:0005523 tropomyosin binding(GO:0005523)
0.7 2.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 2.5 GO:0051117 ATPase binding(GO:0051117)
0.0 2.4 GO:0005125 cytokine activity(GO:0005125)
0.6 2.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 2.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.6 2.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 2.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.3 2.0 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 2.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)