Motif ID: Ikzf2

Z-value: 1.136


Transcription factors associated with Ikzf2:

Gene SymbolEntrez IDGene Name
Ikzf2 ENSMUSG00000025997.7 Ikzf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ikzf2mm10_v2_chr1_-_69685937_696859660.214.8e-01Click!


Activity profile for motif Ikzf2.

activity profile for motif Ikzf2


Sorted Z-values histogram for motif Ikzf2

Sorted Z-values for motif Ikzf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ikzf2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 8.762 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr15_+_3270767 7.378 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr5_-_123141067 5.752 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr1_+_45311538 2.853 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr9_-_42944479 2.021 ENSMUST00000114865.1
Grik4
glutamate receptor, ionotropic, kainate 4
chr6_+_4003926 1.993 ENSMUST00000031670.8
Gng11
guanine nucleotide binding protein (G protein), gamma 11
chr5_-_123140135 1.860 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr6_+_15185203 1.852 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr2_-_71546745 1.701 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr3_+_88214474 1.622 ENSMUST00000181356.1
ENSMUST00000181396.1
Gm3764

predicted gene 3764

chr11_-_55419898 1.439 ENSMUST00000108858.1
ENSMUST00000141530.1
Sparc

secreted acidic cysteine rich glycoprotein

chr12_+_75308308 1.336 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr5_-_134747241 1.249 ENSMUST00000015138.9
Eln
elastin
chr1_-_45503282 1.187 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr1_-_162866502 1.169 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr2_-_77170592 1.163 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr13_-_103764502 1.126 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr3_-_116129615 1.075 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr14_+_54936456 1.045 ENSMUST00000037814.6
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr4_+_105157339 1.012 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr16_-_95459245 0.894 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr19_+_5689131 0.892 ENSMUST00000004156.8
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr5_+_30913398 0.875 ENSMUST00000031055.5
Emilin1
elastin microfibril interfacer 1
chr5_-_51567717 0.868 ENSMUST00000127135.1
ENSMUST00000151104.1
Ppargc1a

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

chr10_+_25359798 0.759 ENSMUST00000053748.8
Epb4.1l2
erythrocyte protein band 4.1-like 2
chr3_-_106001474 0.631 ENSMUST00000066319.6
Pifo
primary cilia formation
chr3_-_65529355 0.624 ENSMUST00000099076.3
4931440P22Rik
RIKEN cDNA 4931440P22 gene
chr17_-_56571438 0.577 ENSMUST00000131056.1
Safb2
scaffold attachment factor B2
chr14_+_64589802 0.575 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr1_-_87394721 0.561 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr16_+_30065333 0.542 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr1_+_63445842 0.541 ENSMUST00000087374.3
ENSMUST00000114107.1
ENSMUST00000182642.1
Adam23


a disintegrin and metallopeptidase domain 23


chr4_-_92191749 0.526 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr7_-_70360593 0.511 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chrX_-_134600976 0.507 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr2_+_103970115 0.466 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr3_+_84925476 0.448 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr9_+_64385675 0.402 ENSMUST00000068967.4
Megf11
multiple EGF-like-domains 11
chr3_+_159839729 0.401 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr12_+_98771018 0.391 ENSMUST00000021399.7
Zc3h14
zinc finger CCCH type containing 14
chrX_+_71556874 0.389 ENSMUST00000123100.1
Hmgb3
high mobility group box 3
chr5_+_107437908 0.365 ENSMUST00000094541.2
Btbd8
BTB (POZ) domain containing 8
chr3_-_33844255 0.360 ENSMUST00000029222.5
Ccdc39
coiled-coil domain containing 39
chr19_+_41593363 0.351 ENSMUST00000099454.3
AI606181
expressed sequence AI606181
chr11_+_23020464 0.334 ENSMUST00000094363.3
ENSMUST00000151877.1
Fam161a

family with sequence similarity 161, member A

chr18_-_36726730 0.332 ENSMUST00000061829.6
Cd14
CD14 antigen
chr5_-_104021919 0.327 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr7_-_139582790 0.324 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr9_-_13446753 0.312 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr2_+_103970221 0.307 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr11_+_49609263 0.294 ENSMUST00000020617.2
Flt4
FMS-like tyrosine kinase 4
chr3_-_108017877 0.267 ENSMUST00000004140.4
Gstm1
glutathione S-transferase, mu 1
chr2_+_174330006 0.265 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr11_-_110251736 0.258 ENSMUST00000044003.7
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_+_94211431 0.256 ENSMUST00000041589.5
Tob1
transducer of ErbB-2.1
chr8_+_128685654 0.249 ENSMUST00000090006.5
Itgb1
integrin beta 1 (fibronectin receptor beta)
chr19_+_55894508 0.247 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr18_+_37484955 0.239 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr10_+_21993890 0.232 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr13_+_89540636 0.225 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr13_+_54590204 0.224 ENSMUST00000026986.6
Higd2a
HIG1 domain family, member 2A
chr3_-_37125943 0.206 ENSMUST00000029275.5
Il2
interleukin 2
chr5_+_110330697 0.203 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr2_-_26409161 0.192 ENSMUST00000145701.1
Inpp5e
inositol polyphosphate-5-phosphatase E
chr16_-_90727329 0.182 ENSMUST00000099554.4
Mis18a
MIS18 kinetochore protein homolog A (S. pombe)
chr3_-_154330543 0.176 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr13_-_56895737 0.168 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr5_-_103211251 0.168 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
Mapk10



mitogen-activated protein kinase 10



chr5_-_104021799 0.135 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr19_-_42202150 0.134 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr13_+_23738804 0.134 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr6_+_59208870 0.132 ENSMUST00000062626.3
Tigd2
tigger transposable element derived 2
chr8_-_67818284 0.128 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr2_-_66410064 0.127 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr14_-_54409469 0.116 ENSMUST00000000984.4
Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr4_+_130107556 0.106 ENSMUST00000030563.5
Pef1
penta-EF hand domain containing 1
chr13_+_44731265 0.105 ENSMUST00000173246.1
Jarid2
jumonji, AT rich interactive domain 2
chr5_-_88527841 0.102 ENSMUST00000087033.3
Igj
immunoglobulin joining chain
chr2_-_7395968 0.102 ENSMUST00000002176.6
Celf2
CUGBP, Elav-like family member 2
chr7_-_84679346 0.097 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr5_+_92897981 0.092 ENSMUST00000113051.2
Shroom3
shroom family member 3
chr9_+_53537021 0.087 ENSMUST00000035850.7
Npat
nuclear protein in the AT region
chr3_+_76075583 0.076 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_-_56978534 0.062 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr13_+_44731281 0.056 ENSMUST00000174086.1
Jarid2
jumonji, AT rich interactive domain 2
chr1_-_69685937 0.035 ENSMUST00000027146.2
Ikzf2
IKAROS family zinc finger 2
chr8_+_45627709 0.029 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr6_-_35133731 0.020 ENSMUST00000114993.2
ENSMUST00000114989.2
ENSMUST00000044163.6
Cnot4


CCR4-NOT transcription complex, subunit 4


chrX_+_109095359 0.019 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chrX_-_153037549 0.018 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr11_-_84525514 0.016 ENSMUST00000018842.7
Lhx1
LIM homeobox protein 1
chr9_+_70207342 0.016 ENSMUST00000034745.7
Myo1e
myosin IE
chr9_-_41157459 0.016 ENSMUST00000136530.1
Ubash3b
ubiquitin associated and SH3 domain containing, B
chr5_-_148392810 0.014 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_+_58394381 0.005 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr11_-_78183551 0.004 ENSMUST00000102483.4
Rpl23a
ribosomal protein L23A
chr8_-_89147247 0.001 ENSMUST00000177870.1
Gm6625
predicted gene 6625

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.6 2.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6 1.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.4 1.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.3 0.5 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 1.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.2 0.9 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.2 0.9 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 1.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.2 GO:0009404 toxin metabolic process(GO:0009404)
0.1 1.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.1 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.2 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 0.3 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.5 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.8 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.1 GO:2000040 regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.6 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.1 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.5 GO:0042447 hormone catabolic process(GO:0042447)
0.0 0.3 GO:0060312 regulation of blood vessel remodeling(GO:0060312)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 1.0 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 0.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 1.2 GO:0051642 centrosome localization(GO:0051642)
0.0 0.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 0.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.0 GO:0072050 comma-shaped body morphogenesis(GO:0072049) S-shaped body morphogenesis(GO:0072050)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 2.1 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0071953 elastic fiber(GO:0071953)
0.4 1.2 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 2.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.2 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.1 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.4 GO:0008430 selenium binding(GO:0008430)
0.3 1.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 2.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.5 GO:0016936 galactoside binding(GO:0016936)
0.1 2.0 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 0.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.5 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.2 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.5 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 1.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.3 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.3 GO:0016151 nickel cation binding(GO:0016151)
0.0 2.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0045295 gamma-catenin binding(GO:0045295)