Motif ID: Glis2

Z-value: 1.109


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_4594735-0.049.0e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_54085542 3.210 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr6_-_48840988 2.982 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr2_-_57113053 2.942 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_-_29984219 2.757 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr2_-_57124003 2.599 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr3_+_121953213 2.566 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr13_-_56296551 2.413 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr6_-_48841098 2.264 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_-_48841373 2.175 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr15_-_85581809 2.139 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr9_+_89909775 1.896 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr19_+_7268296 1.791 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr11_+_103649498 1.753 ENSMUST00000057870.2
 Rprml
reprimo-like
chr2_+_118111876 1.666 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr8_-_109251698 1.652 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr8_-_87472576 1.588 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr14_+_61138445 1.367 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chr3_-_89322883 1.257 ENSMUST00000029673.5
 Efna3
ephrin A3
chr12_+_53248677 1.192 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr1_-_172329261 1.181 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 8.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.4 5.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 2.7 GO:0007050 cell cycle arrest(GO:0007050)
0.8 2.4 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.5 2.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 2.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.7 2.1 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.2 2.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.6 1.7 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) negative regulation of plasminogen activation(GO:0010757)
0.1 1.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 1.2 GO:0032796 uropod organization(GO:0032796)
0.2 1.2 GO:0001842 neural fold formation(GO:0001842)
0.1 1.2 GO:0042711 maternal behavior(GO:0042711)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.2 1.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 1.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 1.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 1.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 2.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 1.7 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.1 1.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.7 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0031672 A band(GO:0031672)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)
0.1 0.5 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 2.7 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.4 GO:0008009 chemokine activity(GO:0008009)
0.0 2.2 GO:0030165 PDZ domain binding(GO:0030165)
0.5 2.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 1.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.6 1.7 GO:0070052 collagen V binding(GO:0070052)
0.0 1.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 1.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 1.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.0 GO:0051087 chaperone binding(GO:0051087)
0.1 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.8 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.8 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.2 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)