Motif ID: Irx5

Z-value: 0.963


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.563.8e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_26623419 3.301 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr12_-_67222549 3.055 ENSMUST00000037181.8
 Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_+_165301863 2.115 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr6_+_50110837 2.069 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr2_-_79908428 1.847 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr2_-_101621033 1.387 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr7_-_98112618 1.348 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr2_-_79908389 1.322 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_-_85035487 1.284 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr3_-_126998408 1.220 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr14_+_48446340 1.120 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr12_-_99393010 1.120 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr5_-_88675190 1.069 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr12_-_108893197 0.999 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_-_99759658 0.971 ENSMUST00000056085.4
 Csl
citrate synthase like
chr1_-_78968079 0.963 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr16_-_55838827 0.956 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr11_-_28339867 0.950 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr5_+_139543889 0.943 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_43632185 0.934 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr14_+_48120841 0.921 ENSMUST00000073150.4
 Peli2
pellino 2
chr10_-_13868779 0.844 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr14_-_19977040 0.803 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr10_+_97565436 0.798 ENSMUST00000038160.4
 Lum
lumican
chr11_-_69395333 0.783 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr3_+_124321031 0.777 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr14_-_19977151 0.763 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr3_+_63963631 0.730 ENSMUST00000181653.1
 Gm26850
predicted gene, 26850
chr12_+_69893105 0.697 ENSMUST00000021466.8
 Atl1
atlastin GTPase 1
chr2_+_152427639 0.648 ENSMUST00000128737.1
 6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr12_+_55598917 0.648 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr4_+_43631935 0.628 ENSMUST00000030191.8
 Npr2
natriuretic peptide receptor 2
chr17_+_21657582 0.564 ENSMUST00000039726.7
 3110052M02Rik
RIKEN cDNA 3110052M02 gene
chr1_-_132707304 0.522 ENSMUST00000043189.7
 Nfasc
neurofascin
chr9_-_78378725 0.508 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr9_-_7835255 0.483 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr2_-_106970391 0.479 ENSMUST00000093883.3
 Arl14ep
ADP-ribosylation factor-like 14 effector protein
chr5_+_23787691 0.478 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
 Rint1



RAD50 interactor 1



chr14_-_19977249 0.441 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr12_-_69892989 0.439 ENSMUST00000110567.1
ENSMUST00000171211.1
 Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr4_-_49521036 0.416 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr17_+_50698525 0.415 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr16_+_33185045 0.380 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr13_+_24943144 0.371 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr4_-_59783800 0.370 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr18_+_76944384 0.358 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
 Hdhd2



haloacid dehalogenase-like hydrolase domain containing 2



chr8_+_85171322 0.347 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr18_+_37806389 0.343 ENSMUST00000076807.4
 Pcdhga9
protocadherin gamma subfamily A, 9
chr11_-_68927049 0.332 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr3_-_88762244 0.320 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr10_+_11609256 0.251 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr3_+_95124476 0.246 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr7_-_114927726 0.207 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chrX_+_135742686 0.205 ENSMUST00000113144.1
ENSMUST00000113147.1
ENSMUST00000113145.1
ENSMUST00000096321.2
 Gprasp1


Armcx5
G protein-coupled receptor associated sorting protein 1


armadillo repeat containing, X-linked 5
chr2_+_104027823 0.156 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr9_+_78051938 0.125 ENSMUST00000024104.7
 Gcm1
glial cells missing homolog 1 (Drosophila)
chr4_+_148039097 0.122 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_-_169969143 0.101 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr5_+_138255608 0.096 ENSMUST00000062067.6
 Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr8_+_4240105 0.069 ENSMUST00000110994.1
ENSMUST00000110995.1
 Map2k7

mitogen-activated protein kinase kinase 7

chr12_-_85288419 0.067 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr6_+_121183667 0.057 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
 Pex26



peroxisomal biogenesis factor 26



chr2_-_73625731 0.055 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr16_-_56024628 0.049 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr17_+_87025550 0.029 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein

chr11_+_69098937 0.029 ENSMUST00000021271.7
 Per1
period circadian clock 1
chr10_+_3872667 0.025 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr2_+_104027721 0.019 ENSMUST00000028603.3
 Fbxo3
F-box protein 3
chr4_+_6365650 0.010 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr10_+_79960145 0.008 ENSMUST00000045247.7
 Wdr18
WD repeat domain 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.4 3.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 1.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 0.8 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 2.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.5 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.5 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 1.3 GO:0050957 equilibrioception(GO:0050957)
0.1 1.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.3 GO:1905154 negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.9 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 1.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.8 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.5 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 3.3 GO:0071564 npBAF complex(GO:0071564)
0.2 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.5 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.2 GO:0031430 M band(GO:0031430)
0.0 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.3 1.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 2.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 2.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)