Motif ID: Irx5

Z-value: 0.963


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.563.8e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_26623419 3.301 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr12_-_67222549 3.055 ENSMUST00000037181.8
 Mdga2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr1_+_165301863 2.115 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr6_+_50110837 2.069 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr2_-_79908428 1.847 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr2_-_101621033 1.387 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr7_-_98112618 1.348 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr2_-_79908389 1.322 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_-_85035487 1.284 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr3_-_126998408 1.220 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr14_+_48446340 1.120 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr12_-_99393010 1.120 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr5_-_88675190 1.069 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr12_-_108893197 0.999 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr10_-_99759658 0.971 ENSMUST00000056085.4
 Csl
citrate synthase like
chr1_-_78968079 0.963 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr16_-_55838827 0.956 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr11_-_28339867 0.950 ENSMUST00000042595.6
 Gm6685
predicted pseudogene 6685
chr5_+_139543889 0.943 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_43632185 0.934 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 3.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 2.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 1.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.4 1.3 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 1.3 GO:0050957 equilibrioception(GO:0050957)
0.1 1.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 1.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.9 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 0.8 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.8 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.2 0.5 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.5 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.5 GO:0007566 embryo implantation(GO:0007566)
0.1 0.4 GO:0010986 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.4 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0071564 npBAF complex(GO:0071564)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.1 GO:0055037 recycling endosome(GO:0055037)
0.0 2.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 1.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.2 GO:0031430 M band(GO:0031430)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.2 0.5 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0005865 striated muscle thin filament(GO:0005865)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 3.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 2.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 2.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 2.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 1.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 1.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.1 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)