Motif ID: Hoxc13_Hoxd13

Z-value: 1.009







Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_16014457 4.212 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr4_+_54945038 3.324 ENSMUST00000133895.1
Zfp462
zinc finger protein 462
chr7_-_73537621 3.198 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr3_-_142169196 2.787 ENSMUST00000098568.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr3_-_142169311 2.610 ENSMUST00000106230.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr6_+_108213086 2.493 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr16_-_74411776 1.634 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr19_-_7341848 1.489 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr18_-_38209762 1.484 ENSMUST00000057185.6
Pcdh1
protocadherin 1
chr11_+_77216180 1.194 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)

chr4_-_133602168 1.072 ENSMUST00000057311.3
Sfn
stratifin
chr6_+_96115249 1.026 ENSMUST00000075080.5
Fam19a1
family with sequence similarity 19, member A1
chr8_+_34807287 0.945 ENSMUST00000033930.4
Dusp4
dual specificity phosphatase 4
chr1_-_56978534 0.937 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_156939387 0.870 ENSMUST00000171292.1
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr17_-_13761441 0.851 ENSMUST00000127032.1
Tcte2
t-complex-associated testis expressed 2
chr5_-_66514815 0.844 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr16_+_23226014 0.824 ENSMUST00000178797.1
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr17_-_6477102 0.753 ENSMUST00000167717.2
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr11_-_95699143 0.724 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr6_+_71909046 0.719 ENSMUST00000055296.8
Polr1a
polymerase (RNA) I polypeptide A
chr11_-_23895208 0.711 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr6_-_49214954 0.704 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr3_+_95658771 0.674 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr17_+_6270475 0.635 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr9_-_77347816 0.632 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr15_+_23036449 0.630 ENSMUST00000164787.1
Cdh18
cadherin 18
chr11_+_75732869 0.609 ENSMUST00000067664.3
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr19_-_41896132 0.592 ENSMUST00000038677.3
Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr11_-_5542177 0.557 ENSMUST00000020776.4
Ccdc117
coiled-coil domain containing 117
chr7_-_119895446 0.519 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chrX_-_7319291 0.517 ENSMUST00000128319.1
Clcn5
chloride channel 5
chr3_+_102735202 0.515 ENSMUST00000119902.1
Tspan2
tetraspanin 2
chr12_-_48559971 0.510 ENSMUST00000169406.1
Gm1818
predicted gene 1818
chr14_+_58070547 0.497 ENSMUST00000165526.1
Fgf9
fibroblast growth factor 9
chr4_-_82850721 0.494 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr6_-_112947246 0.491 ENSMUST00000088373.4
Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr14_+_32321987 0.477 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr9_-_64022043 0.471 ENSMUST00000041029.5
Smad6
SMAD family member 6
chr10_+_56377300 0.460 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr9_-_96719404 0.434 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr8_-_36732897 0.424 ENSMUST00000098826.3
Dlc1
deleted in liver cancer 1
chr10_-_6980376 0.412 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr9_-_77347787 0.407 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr9_-_77347889 0.397 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr2_+_112265809 0.388 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chr16_-_89508313 0.367 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr3_+_59006978 0.361 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chr3_+_95658714 0.354 ENSMUST00000037947.8
Mcl1
myeloid cell leukemia sequence 1
chrX_-_100626568 0.344 ENSMUST00000015812.5
Pdzd11
PDZ domain containing 11
chr14_-_76110760 0.336 ENSMUST00000022585.3
Gpalpp1
GPALPP motifs containing 1
chr10_+_116143881 0.328 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr11_-_5381734 0.299 ENSMUST00000172492.1
Znrf3
zinc and ring finger 3
chr9_-_96719549 0.298 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr4_+_21879662 0.282 ENSMUST00000029909.2
Coq3
coenzyme Q3 homolog, methyltransferase (yeast)
chr5_-_62765618 0.271 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_-_51826562 0.252 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chrX_-_7319186 0.243 ENSMUST00000115746.1
Clcn5
chloride channel 5
chr13_-_21402688 0.190 ENSMUST00000117721.1
ENSMUST00000070785.8
ENSMUST00000116433.1
ENSMUST00000116434.3
Zkscan3



zinc finger with KRAB and SCAN domains 3



chr7_-_30612731 0.189 ENSMUST00000006476.4
Upk1a
uroplakin 1A
chr18_+_37355271 0.184 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr14_-_103346765 0.174 ENSMUST00000159855.1
Mycbp2
MYC binding protein 2
chr17_+_75178797 0.167 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr8_+_13339656 0.154 ENSMUST00000170909.1
Tfdp1
transcription factor Dp 1
chr1_+_53313636 0.136 ENSMUST00000114484.1
Osgepl1
O-sialoglycoprotein endopeptidase-like 1
chr8_+_83666827 0.133 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr8_+_33653238 0.132 ENSMUST00000033992.8
Gsr
glutathione reductase
chr6_-_71823805 0.128 ENSMUST00000065103.2
Mrpl35
mitochondrial ribosomal protein L35
chr3_-_88458876 0.128 ENSMUST00000147200.1
ENSMUST00000169222.1
Sema4a

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

chr18_+_36744656 0.127 ENSMUST00000007042.5
Ik
IK cytokine
chr9_-_50659780 0.122 ENSMUST00000034567.3
Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr7_-_34655500 0.111 ENSMUST00000032709.1
Kctd15
potassium channel tetramerisation domain containing 15
chr5_+_105876532 0.109 ENSMUST00000150440.1
ENSMUST00000031227.4
Zfp326

zinc finger protein 326

chr3_-_88459047 0.096 ENSMUST00000165898.1
ENSMUST00000127436.1
Sema4a

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

chr1_+_85100164 0.092 ENSMUST00000097669.1
Gm10553
predicted gene 10553
chr4_-_44710408 0.090 ENSMUST00000134968.2
ENSMUST00000173821.1
ENSMUST00000174319.1
ENSMUST00000173733.1
ENSMUST00000172866.1
ENSMUST00000165417.2
ENSMUST00000107825.2
ENSMUST00000102932.3
ENSMUST00000107827.2
ENSMUST00000107826.2
Pax5









paired box gene 5









chr14_+_77156733 0.081 ENSMUST00000022589.7
Enox1
ecto-NOX disulfide-thiol exchanger 1
chr5_+_86804214 0.062 ENSMUST00000119339.1
ENSMUST00000120498.1
Ythdc1

YTH domain containing 1

chr16_+_75592844 0.062 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr19_+_23619742 0.048 ENSMUST00000104916.2
Gm9493
predicted gene 9493
chr19_-_7341792 0.043 ENSMUST00000164205.1
ENSMUST00000165286.1
ENSMUST00000168324.1
ENSMUST00000032557.8
Mark2



MAP/microtubule affinity-regulating kinase 2



chr5_-_135064063 0.041 ENSMUST00000111205.1
ENSMUST00000141309.1
Wbscr22

Williams Beuren syndrome chromosome region 22

chr1_+_59256906 0.039 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr5_-_114858682 0.036 ENSMUST00000066959.4
Gm9936
predicted gene 9936
chr3_+_126597415 0.029 ENSMUST00000066452.7
ENSMUST00000171289.1
ENSMUST00000106399.1
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr17_+_8283762 0.027 ENSMUST00000155364.1
ENSMUST00000046754.8
ENSMUST00000124023.1
Mpc1


mitochondrial pyruvate carrier 1


chr17_-_53867041 0.012 ENSMUST00000061311.7
Mrps36-ps1
mitichondrial ribosomal protein S36, pseudogene 1
chr5_+_92809372 0.012 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr11_-_102407455 0.003 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.8 4.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.5 1.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 2.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.3 1.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 0.6 GO:0009405 pathogenesis(GO:0009405)
0.2 0.8 GO:1990743 protein sialylation(GO:1990743)
0.2 3.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 0.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 0.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 0.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.1 1.1 GO:0031424 keratinization(GO:0031424)
0.1 0.6 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.4 GO:0071476 cellular hypotonic response(GO:0071476)
0.1 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 1.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 3.3 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.5 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.5 GO:0032927 cardiac left ventricle morphogenesis(GO:0003214) positive regulation of activin receptor signaling pathway(GO:0032927) lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.3 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.5 GO:0010225 response to UV-C(GO:0010225)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 1.2 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.7 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.2 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0043512 inhibin A complex(GO:0043512)
0.8 2.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 1.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.8 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.5 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.7 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 4.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.6 5.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.5 0.5 GO:0070697 activin receptor binding(GO:0070697)
0.2 1.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.0 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.7 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 1.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.6 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.2 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 1.1 GO:0051219 phosphoprotein binding(GO:0051219)