Motif ID: Isl1

Z-value: 0.648


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.431.3e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93519499 2.696 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr14_-_12345847 2.387 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr6_-_144209558 2.243 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 2.210 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 2.195 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr16_-_22161450 1.743 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr18_-_47333311 1.588 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr12_-_86884808 1.186 ENSMUST00000038422.6
 Irf2bpl
interferon regulatory factor 2 binding protein-like
chr1_-_183147461 1.009 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr2_+_67748212 1.002 ENSMUST00000180887.1
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_+_153237466 0.868 ENSMUST00000143880.1
 Klf8
Kruppel-like factor 8
chrX_-_43274786 0.810 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr15_+_44196135 0.644 ENSMUST00000038856.6
ENSMUST00000110289.3
 Trhr

thyrotropin releasing hormone receptor

chr1_-_79440039 0.613 ENSMUST00000049972.4
 Scg2
secretogranin II
chrX_-_143933089 0.595 ENSMUST00000087313.3
 Dcx
doublecortin
chr11_-_60913775 0.577 ENSMUST00000019075.3
 Gm16515
predicted gene, Gm16515
chr2_-_72986716 0.549 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr14_+_13453937 0.541 ENSMUST00000153954.1
 Synpr
synaptoporin
chr8_+_45507768 0.528 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr12_-_27342696 0.503 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.9 2.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.4 2.4 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.7 GO:0051028 mRNA transport(GO:0051028)
0.1 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 1.0 GO:0060539 diaphragm development(GO:0060539)
0.1 1.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 0.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.2 0.5 GO:0060023 noradrenergic neuron differentiation(GO:0003357) soft palate development(GO:0060023)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.4 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:0001880 Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 2.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 1.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.0 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.6 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)