Motif ID: Isl1
Z-value: 0.648
Transcription factors associated with Isl1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Isl1 | ENSMUSG00000042258.7 | Isl1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Isl1 | mm10_v2_chr13_-_116309639_116309699 | -0.43 | 1.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.7 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.8 | 6.6 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.4 | 2.4 | GO:1904936 | forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.2 | 0.5 | GO:0060023 | noradrenergic neuron differentiation(GO:0003357) soft palate development(GO:0060023) |
0.2 | 0.5 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.1 | 0.4 | GO:1901731 | calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731) |
0.1 | 0.6 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 1.2 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.1 | 0.5 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.1 | 0.4 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.1 | 1.0 | GO:0060539 | diaphragm development(GO:0060539) |
0.1 | 1.6 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
0.1 | 1.0 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.1 | 1.0 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
0.1 | 0.4 | GO:0001880 | Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051) |
0.1 | 0.6 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.1 | 0.3 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.1 | 0.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.1 | 0.2 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
0.1 | 1.3 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
0.1 | 0.2 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
0.0 | 0.1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) |
0.0 | 0.1 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
0.0 | 0.3 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.0 | 0.2 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.0 | 0.1 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) UDP metabolic process(GO:0046048) dUDP metabolic process(GO:0046077) |
0.0 | 0.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.4 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.0 | 0.1 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
0.0 | 0.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.0 | 0.2 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
0.0 | 0.2 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
0.0 | 0.1 | GO:0001778 | plasma membrane repair(GO:0001778) |
0.0 | 0.4 | GO:0098743 | cartilage condensation(GO:0001502) cell aggregation(GO:0098743) |
0.0 | 0.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 0.3 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 1.7 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 0.4 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.1 | 0.5 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 0.1 | GO:0070939 | Dsl1p complex(GO:0070939) |
0.0 | 0.6 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 5.8 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
0.0 | 0.8 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.1 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.0 | 0.4 | GO:0035102 | PRC1 complex(GO:0035102) |
0.0 | 0.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 0.1 | GO:0097513 | myosin II filament(GO:0097513) |
0.0 | 0.5 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 0.1 | GO:0071986 | Ragulator complex(GO:0071986) |
0.0 | 2.5 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.1 | 1.0 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
0.1 | 1.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.1 | 0.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.1 | 0.3 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
0.1 | 1.0 | GO:0015197 | peptide transporter activity(GO:0015197) |
0.1 | 0.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.0 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 1.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 1.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.0 | 0.2 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.0 | 0.1 | GO:0004127 | cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041) |
0.0 | 0.2 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
0.0 | 0.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.5 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 0.2 | GO:0050692 | DBD domain binding(GO:0050692) |
0.0 | 0.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.4 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.2 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.0 | 0.3 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
0.0 | 0.2 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.0 | 7.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
0.0 | 0.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |