Motif ID: Isl1

Z-value: 0.648


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.431.3e-01Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_93519499 2.696 ENSMUST00000109255.2
Prickle1
prickle homolog 1 (Drosophila)
chr14_-_12345847 2.387 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr6_-_144209558 2.243 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr6_-_144209471 2.210 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr6_-_144209448 2.195 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr16_-_22161450 1.743 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr18_-_47333311 1.588 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr12_-_86884808 1.186 ENSMUST00000038422.6
Irf2bpl
interferon regulatory factor 2 binding protein-like
chr1_-_183147461 1.009 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr2_+_67748212 1.002 ENSMUST00000180887.1
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_+_153237466 0.868 ENSMUST00000143880.1
Klf8
Kruppel-like factor 8
chrX_-_43274786 0.810 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr15_+_44196135 0.644 ENSMUST00000038856.6
ENSMUST00000110289.3
Trhr

thyrotropin releasing hormone receptor

chr1_-_79440039 0.613 ENSMUST00000049972.4
Scg2
secretogranin II
chrX_-_143933089 0.595 ENSMUST00000087313.3
Dcx
doublecortin
chr11_-_60913775 0.577 ENSMUST00000019075.3
Gm16515
predicted gene, Gm16515
chr2_-_72986716 0.549 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr14_+_13453937 0.541 ENSMUST00000153954.1
Synpr
synaptoporin
chr8_+_45507768 0.528 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2





sorbin and SH3 domain containing 2





chr12_-_27342696 0.503 ENSMUST00000079063.5
Sox11
SRY-box containing gene 11
chr14_-_52237572 0.490 ENSMUST00000089752.4
Chd8
chromodomain helicase DNA binding protein 8
chr10_+_18469958 0.479 ENSMUST00000162891.1
ENSMUST00000100054.3
Nhsl1

NHS-like 1

chr8_-_105568298 0.477 ENSMUST00000005849.5
Agrp
agouti related protein
chr10_+_88091070 0.462 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chrX_-_143933204 0.445 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr6_+_30568367 0.436 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr11_-_69822144 0.416 ENSMUST00000045771.6
Spem1
sperm maturation 1
chr14_-_70630149 0.396 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr17_+_71204647 0.389 ENSMUST00000126681.1
Lpin2
lipin 2
chr12_-_12941827 0.383 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr4_+_128654686 0.381 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr2_-_152398046 0.380 ENSMUST00000063332.8
ENSMUST00000182625.1
Sox12

SRY-box containing gene 12

chr1_+_12718496 0.368 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr3_-_25212720 0.368 ENSMUST00000091289.3
Gm10259
predicted pseudogene 10259
chr2_+_71211941 0.354 ENSMUST00000112144.2
ENSMUST00000100028.3
ENSMUST00000112136.1
Dync1i2


dynein cytoplasmic 1 intermediate chain 2


chr10_+_69534208 0.350 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chr9_+_35423582 0.350 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr9_+_113812547 0.349 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr7_+_119760918 0.335 ENSMUST00000106527.1
ENSMUST00000106528.1
ENSMUST00000063770.3
ENSMUST00000106529.1
Acsm3



acyl-CoA synthetase medium-chain family member 3



chr4_-_82850721 0.316 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr13_+_93308006 0.315 ENSMUST00000079086.6
Homer1
homer homolog 1 (Drosophila)
chr10_-_128176568 0.315 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr1_-_57970104 0.313 ENSMUST00000114410.3
Kctd18
potassium channel tetramerisation domain containing 18
chr1_-_57970067 0.308 ENSMUST00000164963.1
Kctd18
potassium channel tetramerisation domain containing 18
chr9_+_3404058 0.276 ENSMUST00000027027.5
Cwf19l2
CWF19-like 2, cell cycle control (S. pombe)
chr4_+_3940747 0.270 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr3_-_127225917 0.258 ENSMUST00000182064.1
ENSMUST00000182662.1
Ank2

ankyrin 2, brain

chr13_+_56703504 0.256 ENSMUST00000109874.1
Smad5
SMAD family member 5
chr15_-_50889691 0.255 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr3_-_127225847 0.250 ENSMUST00000182726.1
ENSMUST00000182779.1
Ank2

ankyrin 2, brain

chr18_+_4375583 0.237 ENSMUST00000025077.6
Mtpap
mitochondrial poly(A) polymerase
chr14_-_78536762 0.227 ENSMUST00000123853.1
Akap11
A kinase (PRKA) anchor protein 11
chr5_+_121777929 0.225 ENSMUST00000160821.1
Atxn2
ataxin 2
chr3_+_89520152 0.221 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr4_+_74013442 0.221 ENSMUST00000098006.2
ENSMUST00000084474.5
Frmd3

FERM domain containing 3

chrX_+_153237748 0.206 ENSMUST00000112574.2
Klf8
Kruppel-like factor 8
chr13_-_23991158 0.184 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr14_-_118052235 0.171 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr14_-_36935560 0.170 ENSMUST00000183038.1
Ccser2
coiled-coil serine rich 2
chrX_+_151198078 0.164 ENSMUST00000184730.1
ENSMUST00000184392.1
ENSMUST00000096285.4
Wnk3


WNK lysine deficient protein kinase 3


chr2_-_71367749 0.162 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr13_+_56702983 0.159 ENSMUST00000069557.7
ENSMUST00000109876.1
Smad5

SMAD family member 5

chr8_-_33747724 0.159 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr16_-_97170707 0.153 ENSMUST00000056102.7
Dscam
Down syndrome cell adhesion molecule
chr11_+_74649462 0.148 ENSMUST00000092915.5
ENSMUST00000117818.1
Cluh

clustered mitochondria (cluA/CLU1) homolog

chr5_+_23787691 0.141 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
Rint1



RAD50 interactor 1



chr9_-_44767792 0.140 ENSMUST00000034607.9
Arcn1
archain 1
chr3_-_104818539 0.133 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr8_+_84723003 0.130 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr3_-_123690806 0.122 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_-_5266038 0.114 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14


cyclin-dependent kinase 14


chr4_-_114987220 0.113 ENSMUST00000030491.8
Cmpk1
cytidine monophosphate (UMP-CMP) kinase 1
chr4_-_42661893 0.109 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr1_-_170867761 0.106 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr7_+_141216626 0.105 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr13_-_75943812 0.095 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chr17_-_35235755 0.093 ENSMUST00000048994.6
Nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr4_-_42168603 0.093 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr11_-_4594750 0.092 ENSMUST00000109943.3
Mtmr3
myotubularin related protein 3
chr18_-_15718046 0.080 ENSMUST00000053017.6
Chst9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr9_-_112217261 0.080 ENSMUST00000159451.1
ENSMUST00000162796.1
ENSMUST00000161097.1
Arpp21


cyclic AMP-regulated phosphoprotein, 21


chr8_-_61902669 0.079 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr8_-_54718664 0.078 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr2_+_158794807 0.071 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr3_-_88552859 0.067 ENSMUST00000119002.1
ENSMUST00000029698.8
Lamtor2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

chr10_-_13388753 0.063 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr11_+_68692070 0.063 ENSMUST00000108673.1
Myh10
myosin, heavy polypeptide 10, non-muscle
chrX_+_96455359 0.059 ENSMUST00000033553.7
Heph
hephaestin
chr15_-_50890396 0.058 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chrX_+_106920618 0.052 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr18_+_6332587 0.045 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr11_+_68692097 0.044 ENSMUST00000018887.8
Myh10
myosin, heavy polypeptide 10, non-muscle
chr11_-_76509419 0.041 ENSMUST00000094012.4
Abr
active BCR-related gene
chr9_-_112217344 0.038 ENSMUST00000161412.1
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr7_-_118116128 0.036 ENSMUST00000128482.1
ENSMUST00000131840.1
Rps15a

ribosomal protein S15A

chr18_-_42579652 0.035 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr14_+_124005355 0.030 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr2_-_168955529 0.024 ENSMUST00000109162.2
Zfp64
zinc finger protein 64
chr4_-_120951664 0.021 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr18_-_75697639 0.020 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr4_+_108719649 0.016 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr15_-_50882806 0.011 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr4_-_41045381 0.003 ENSMUST00000054945.7
Aqp7
aquaporin 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.8 6.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 2.4 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 0.5 GO:0060023 noradrenergic neuron differentiation(GO:0003357) soft palate development(GO:0060023)
0.2 0.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 0.4 GO:1901731 calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731)
0.1 0.6 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.0 GO:0060539 diaphragm development(GO:0060539)
0.1 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.0 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.0 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 0.4 GO:0001880 Mullerian duct regression(GO:0001880) osteoblast fate commitment(GO:0002051)
0.1 0.6 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 1.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.2 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.1 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) UDP metabolic process(GO:0046048) dUDP metabolic process(GO:0046077)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.2 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.4 GO:0098743 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.7 GO:0051028 mRNA transport(GO:0051028)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 5.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.8 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 2.5 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.0 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 1.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 1.0 GO:0015197 peptide transporter activity(GO:0015197)
0.1 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 7.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)