Motif ID: Tbx21

Z-value: 0.531


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_86546795 0.900 ENSMUST00000167814.1
 Gm17530
predicted gene, 17530
chr11_-_70656467 0.758 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr16_-_4003750 0.595 ENSMUST00000171658.1
ENSMUST00000171762.1
 Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr1_-_56969827 0.550 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_106656081 0.440 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr3_-_127499095 0.438 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr1_-_56969864 0.436 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_12460749 0.343 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr8_+_40423786 0.318 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
 Zdhhc2


zinc finger, DHHC domain containing 2


chr2_-_121442574 0.288 ENSMUST00000116432.1
 Ell3
elongation factor RNA polymerase II-like 3
chr12_-_87233556 0.286 ENSMUST00000021423.7
 Noxred1
NADP+ dependent oxidoreductase domain containing 1
chr8_-_68735058 0.272 ENSMUST00000136060.1
ENSMUST00000130214.1
ENSMUST00000078350.6
 Csgalnact1


chondroitin sulfate N-acetylgalactosaminyltransferase 1


chr1_+_62703667 0.270 ENSMUST00000114155.1
ENSMUST00000027112.6
ENSMUST00000063594.6
ENSMUST00000114157.2
 Nrp2



neuropilin 2



chr7_-_29954049 0.256 ENSMUST00000108211.1
ENSMUST00000108205.1
 Zfp74

zinc finger protein 74

chr7_-_4789541 0.247 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr3_+_14863495 0.234 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr11_+_24080664 0.233 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr2_+_28641227 0.219 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr2_+_164823001 0.211 ENSMUST00000132282.1
 Zswim1
zinc finger SWIM-type containing 1
chr9_-_85749308 0.210 ENSMUST00000039213.8
 Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 0.6 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.2 0.5 GO:0021649 vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.0 0.4 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.4 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.3 GO:0046398 UDP-N-acetylgalactosamine metabolic process(GO:0019276) UDP-glucuronate metabolic process(GO:0046398)
0.0 0.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.2 GO:0043379 memory T cell differentiation(GO:0043379)
0.0 0.2 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.2 GO:0034331 cell junction maintenance(GO:0034331)
0.0 0.2 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.0 0.1 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.1 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.3 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0050827 toxin receptor binding(GO:0050827)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)