Motif ID: Tbx5

Z-value: 0.849


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.097.6e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_37528071 2.858 ENSMUST00000002011.7
 Esam
endothelial cell-specific adhesion molecule
chr5_+_111733924 1.937 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr8_-_105637403 1.428 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr16_+_91225550 1.312 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr5_+_17574726 1.163 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_+_55336424 1.162 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr11_-_69900949 1.106 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr16_+_17276291 1.075 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr18_+_5591860 1.057 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chr3_-_115715031 1.041 ENSMUST00000055676.2
 S1pr1
sphingosine-1-phosphate receptor 1
chr16_+_17276337 1.035 ENSMUST00000159065.1
ENSMUST00000159494.1
ENSMUST00000159811.1
 Tmem191c


transmembrane protein 191C


chr11_-_69900930 1.002 ENSMUST00000018714.6
ENSMUST00000128046.1
 2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr4_-_41517326 0.973 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr4_+_139923349 0.949 ENSMUST00000128563.1
 Gm13028
predicted gene 13028
chr10_+_60346851 0.943 ENSMUST00000020301.7
ENSMUST00000105460.1
ENSMUST00000170507.1
 4632428N05Rik


RIKEN cDNA 4632428N05 gene


chr9_+_103008479 0.938 ENSMUST00000035148.6
 Slco2a1
solute carrier organic anion transporter family, member 2a1
chr3_+_126596993 0.929 ENSMUST00000163226.1
ENSMUST00000066466.6
ENSMUST00000169051.1
 Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr16_+_93683184 0.873 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr15_-_89425795 0.845 ENSMUST00000168376.1
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr6_+_124304646 0.823 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.3 2.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 2.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.3 1.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 1.4 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.4 1.3 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 1.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.0 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 1.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.0 GO:0051150 regulation of smooth muscle cell differentiation(GO:0051150)
0.1 0.9 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.9 GO:0009109 coenzyme catabolic process(GO:0009109)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.2 0.8 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.8 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.1 0.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.8 GO:0006953 acute-phase response(GO:0006953)
0.0 0.8 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.2 GO:0032127 dense core granule membrane(GO:0032127)
0.2 1.1 GO:0002177 manchette(GO:0002177)
0.0 0.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0043596 nuclear replication fork(GO:0043596)
0.2 0.5 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.0 0.5 GO:0005882 intermediate filament(GO:0005882)
0.1 0.4 GO:0097227 sperm annulus(GO:0097227)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.4 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0031432 titin binding(GO:0031432)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.3 1.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.1 1.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.0 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.3 0.9 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.9 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)