Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.602

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx1mm10_v2_chr10_-_103028771_103028782-0.451.1e-01Click!
Gsx1mm10_v2_chr5_+_147188678_1471886960.058.8e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_72986716 1.924 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr2_+_152754156 0.919 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chrX_-_9256899 0.882 ENSMUST00000115553.2
 Gm14862
predicted gene 14862
chr5_-_84417359 0.695 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr4_-_155056784 0.648 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr3_+_122044428 0.631 ENSMUST00000013995.8
 Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr17_-_48432723 0.623 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chrM_+_10167 0.528 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr13_+_44121167 0.527 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chrX_-_143933089 0.486 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_-_55919605 0.482 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr2_+_69897255 0.462 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr1_-_172027251 0.447 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr11_+_29373618 0.432 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chrX_-_74246534 0.425 ENSMUST00000101454.2
ENSMUST00000033699.6
 Flna

filamin, alpha

chr17_+_34305883 0.419 ENSMUST00000074557.8
 H2-Eb1
histocompatibility 2, class II antigen E beta
chr2_+_116067213 0.419 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chrM_+_9870 0.409 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr7_+_103550368 0.399 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chrX_-_143933204 0.394 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 0.8 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.6 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.2 0.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.5 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.4 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.4 GO:0060178 regulation of exocyst localization(GO:0060178)
0.0 0.4 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.4 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0070469 respiratory chain(GO:0070469)
0.1 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.5 GO:0031523 Myb complex(GO:0031523)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)