Motif ID: Gata2_Gata1

Z-value: 1.392

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.805.6e-04Click!
Gata1mm10_v2_chrX_-_7967817_79679100.332.5e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 158 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_84701430 7.022 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr6_+_30541582 5.886 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr1_-_162866502 5.407 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr3_+_135825788 3.904 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr2_+_169633517 3.737 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr16_-_95459245 3.661 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr11_+_90030295 3.527 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr13_-_116309639 3.320 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr6_+_125552948 3.296 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr13_+_38345716 3.155 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr7_-_4522427 3.103 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr2_+_169632996 3.071 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr16_+_45093611 2.900 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr7_+_110627650 2.895 ENSMUST00000033054.8
 Adm
adrenomedullin
chr16_+_45094036 2.740 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr10_-_115185015 2.583 ENSMUST00000006949.8
 Tph2
tryptophan hydroxylase 2
chr9_-_32541589 2.552 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr7_-_139582790 2.537 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr16_-_64786321 2.420 ENSMUST00000052588.4
 Zfp654
zinc finger protein 654
chr7_+_28833975 2.417 ENSMUST00000066723.8
 Lgals4
lectin, galactose binding, soluble 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.0 GO:0001955 blood vessel maturation(GO:0001955)
0.6 6.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.6 6.1 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 5.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.5 5.4 GO:0009404 toxin metabolic process(GO:0009404)
0.9 5.1 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.0 4.7 GO:0030168 platelet activation(GO:0030168)
0.7 3.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
1.1 3.3 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.5 3.2 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 2.9 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.4 2.6 GO:1901162 tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586) serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1 2.6 GO:0035855 megakaryocyte development(GO:0035855)
0.4 2.5 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 2.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 2.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 2.2 GO:0045332 phospholipid translocation(GO:0045332)
0.1 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 2.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.3 1.9 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.1 GO:0005861 troponin complex(GO:0005861)
0.3 4.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.5 GO:0043204 perikaryon(GO:0043204)
0.7 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 2.2 GO:0055037 recycling endosome(GO:0055037)
0.0 2.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.3 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.3 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 1.0 GO:0097441 basilar dendrite(GO:0097441)
0.0 1.0 GO:0042383 sarcolemma(GO:0042383)
0.3 0.8 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 6.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 5.6 GO:0001968 fibronectin binding(GO:0001968)
1.1 5.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 5.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.7 5.1 GO:0030172 troponin C binding(GO:0030172)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.4 3.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.3 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 2.9 GO:0005179 hormone activity(GO:0005179)
0.9 2.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 2.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 2.4 GO:0016936 galactoside binding(GO:0016936)
0.1 2.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.1 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.4 2.0 GO:0070051 fibrinogen binding(GO:0070051)
0.1 2.0 GO:0005540 hyaluronic acid binding(GO:0005540)