Motif ID: Thrb

Z-value: 0.930


Transcription factors associated with Thrb:

Gene SymbolEntrez IDGene Name
Thrb ENSMUSG00000021779.10 Thrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thrbmm10_v2_chr14_+_17660956_176609630.525.9e-02Click!


Activity profile for motif Thrb.

activity profile for motif Thrb


Sorted Z-values histogram for motif Thrb

Sorted Z-values for motif Thrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Thrb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_25470031 6.757 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 5.818 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr16_+_36934976 2.713 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr5_-_111761697 2.438 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr9_-_107668967 2.196 ENSMUST00000177567.1
 Slc38a3
solute carrier family 38, member 3
chr12_+_112620030 1.900 ENSMUST00000180015.1
ENSMUST00000021726.6
 Adssl1

adenylosuccinate synthetase like 1

chr3_+_14863495 1.316 ENSMUST00000029076.4
 Car3
carbonic anhydrase 3
chr5_-_92278155 1.288 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr11_-_115612491 1.202 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr11_+_109485606 1.177 ENSMUST00000106697.1
 Arsg
arylsulfatase G
chr12_+_108334341 1.161 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr1_-_137969213 1.145 ENSMUST00000182680.1
ENSMUST00000182424.1
 Gm26936

predicted gene, 26936

chr11_-_103344651 0.970 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr5_-_30461902 0.953 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr3_+_67374091 0.811 ENSMUST00000077916.5
 Mlf1
myeloid leukemia factor 1
chr14_+_54476100 0.702 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr3_+_67374116 0.673 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr3_-_116712198 0.591 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr4_+_20042046 0.497 ENSMUST00000098242.3
 Ggh
gamma-glutamyl hydrolase
chr2_-_105399286 0.475 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr3_-_79842662 0.470 ENSMUST00000029568.1
 Tmem144
transmembrane protein 144
chr7_+_101896817 0.434 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chr15_-_100669496 0.398 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr3_-_36475688 0.397 ENSMUST00000029266.8
 Anxa5
annexin A5
chr9_-_102626095 0.338 ENSMUST00000093791.3
 Cep63
centrosomal protein 63
chr16_-_17144415 0.308 ENSMUST00000115709.1
 Ccdc116
coiled-coil domain containing 116
chr4_+_152178126 0.273 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chr16_+_37916440 0.226 ENSMUST00000061274.7
 Gpr156
G protein-coupled receptor 156
chrX_-_78583882 0.201 ENSMUST00000114025.1
ENSMUST00000134602.1
ENSMUST00000114024.2
 Prrg1


proline rich Gla (G-carboxyglutamic acid) 1


chr9_-_102626509 0.176 ENSMUST00000161645.1
ENSMUST00000162297.1
ENSMUST00000162655.1
 Cep63


centrosomal protein 63


chr9_+_102626278 0.169 ENSMUST00000038673.7
 Anapc13
anaphase promoting complex subunit 13
chrX_-_78583782 0.115 ENSMUST00000177904.1
 Prrg1
proline rich Gla (G-carboxyglutamic acid) 1
chr11_-_58938851 0.072 ENSMUST00000094151.5
 Rnf187
ring finger protein 187
chr5_+_108065742 0.066 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
 Mtf2


metal response element binding transcription factor 2


chr13_-_92530813 0.062 ENSMUST00000022217.8
 Zfyve16
zinc finger, FYVE domain containing 16
chr2_-_24049389 0.013 ENSMUST00000051416.5
 Hnmt
histamine N-methyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.5 2.2 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.4 1.9 GO:0006167 AMP biosynthetic process(GO:0006167)
0.3 2.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 0.5 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.2 1.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.6 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.4 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.3 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.5 GO:0090220 meiotic telomere clustering(GO:0045141) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.0 1.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 1.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.4 GO:0071800 podosome assembly(GO:0071800)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 12.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.5 GO:0031514 motile cilium(GO:0031514)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 2.2 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1 1.2 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 1.3 GO:0016151 nickel cation binding(GO:0016151)
0.1 1.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.3 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 1.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.5 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 3.7 GO:0017124 SH3 domain binding(GO:0017124)