Motif ID: Irf3

Z-value: 1.156


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.283.3e-01Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_71537402 2.671 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr5_+_114896936 1.931 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
 Oasl2


2'-5' oligoadenylate synthetase-like 2


chr6_-_39118211 1.779 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_+_122147680 1.628 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr16_+_35938470 1.279 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr18_-_32559914 1.168 ENSMUST00000174000.1
ENSMUST00000174459.1
 Gypc

glycophorin C

chr7_-_100514800 1.052 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr13_-_23710714 1.030 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr4_-_156200818 0.956 ENSMUST00000085425.4
 Isg15
ISG15 ubiquitin-like modifier
chr15_+_32920723 0.938 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr6_-_23839137 0.926 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
 Cadps2







Ca2+-dependent activator protein for secretion 2







chr3_-_151749877 0.911 ENSMUST00000029671.7
 Ifi44
interferon-induced protein 44
chr2_-_51934644 0.905 ENSMUST00000165313.1
 Rbm43
RNA binding motif protein 43
chr7_-_104315455 0.893 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
 Trim12a


tripartite motif-containing 12A


chr1_-_75317536 0.892 ENSMUST00000066668.7
 Dnpep
aspartyl aminopeptidase
chr16_+_35938972 0.883 ENSMUST00000023622.6
ENSMUST00000114877.1
 Parp9

poly (ADP-ribose) polymerase family, member 9

chr3_+_142530329 0.827 ENSMUST00000171263.1
ENSMUST00000045097.9
 Gbp7

guanylate binding protein 7

chr3_+_81932601 0.821 ENSMUST00000029649.2
 Ctso
cathepsin O
chr14_-_65833963 0.810 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr1_-_75316998 0.807 ENSMUST00000113605.3
 Dnpep
aspartyl aminopeptidase
chr11_-_48871344 0.804 ENSMUST00000049519.3
 Irgm1
immunity-related GTPase family M member 1
chr11_-_48871408 0.787 ENSMUST00000097271.2
 Irgm1
immunity-related GTPase family M member 1
chr8_-_70766654 0.785 ENSMUST00000034299.5
 Ifi30
interferon gamma inducible protein 30
chr3_+_142560052 0.735 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr9_+_20868628 0.714 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr2_-_173276144 0.710 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr19_+_43752996 0.699 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chr1_+_61638819 0.672 ENSMUST00000138768.1
ENSMUST00000075374.3
 Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chrX_+_68678541 0.608 ENSMUST00000088546.5
 Fmr1
fragile X mental retardation syndrome 1
chr2_+_167062934 0.574 ENSMUST00000125674.1
 1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr2_+_180589245 0.561 ENSMUST00000029087.3
 Ogfr
opioid growth factor receptor
chr2_-_173218879 0.559 ENSMUST00000109116.2
ENSMUST00000029018.7
 Zbp1

Z-DNA binding protein 1

chr19_+_36409719 0.546 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr4_-_40239779 0.538 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_72301613 0.506 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr3_+_142560351 0.486 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr13_+_40859768 0.467 ENSMUST00000110191.2
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr7_-_141266415 0.439 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
 Irf7


interferon regulatory factor 7


chr11_+_119393060 0.433 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr6_-_34317442 0.425 ENSMUST00000154655.1
ENSMUST00000102980.4
 Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr6_-_125231772 0.417 ENSMUST00000043422.7
 Tapbpl
TAP binding protein-like
chr3_+_142560108 0.415 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr2_+_145934800 0.390 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
 4930529M08Rik




RIKEN cDNA 4930529M08 gene




chr2_-_51934943 0.376 ENSMUST00000102767.1
ENSMUST00000102768.1
 Rbm43

RNA binding motif protein 43

chr11_-_49064202 0.372 ENSMUST00000046745.6
 Tgtp2
T cell specific GTPase 2
chr17_+_21008921 0.362 ENSMUST00000088811.5
 Zfp160
zinc finger protein 160
chr17_+_75178911 0.359 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr17_+_75178797 0.348 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr1_-_85109449 0.339 ENSMUST00000161724.1
 A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr7_-_45136231 0.328 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chrX_+_68678712 0.318 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
 Fmr1



fragile X mental retardation syndrome 1



chr17_+_57358682 0.315 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr14_+_14012491 0.312 ENSMUST00000022257.2
 Atxn7
ataxin 7
chr11_-_48992226 0.310 ENSMUST00000059930.2
ENSMUST00000068063.3
 Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chrX_+_68678624 0.309 ENSMUST00000114656.1
 Fmr1
fragile X mental retardation syndrome 1
chr11_+_58199556 0.287 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
 Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr14_+_55578360 0.253 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
 Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr16_-_10785525 0.243 ENSMUST00000038099.4
 Socs1
suppressor of cytokine signaling 1
chr14_+_55578123 0.233 ENSMUST00000174484.1
 Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr1_+_37890477 0.225 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr4_-_40239700 0.222 ENSMUST00000142055.1
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr15_+_79892436 0.213 ENSMUST00000175752.1
ENSMUST00000176325.1
 Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr11_+_109362771 0.193 ENSMUST00000020930.7
ENSMUST00000106702.3
 Gna13

guanine nucleotide binding protein, alpha 13

chr15_+_79892397 0.192 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
 Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr1_-_85598796 0.181 ENSMUST00000093508.6
 Sp110
Sp110 nuclear body protein
chr10_-_81496313 0.160 ENSMUST00000118498.1
 Ncln
nicalin homolog (zebrafish)
chr14_-_55591077 0.154 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
 Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr19_-_44146433 0.148 ENSMUST00000079033.4
 Bloc1s2
biogenesis of lysosome-related organelles complex-1, subunit 2
chr10_-_81496329 0.147 ENSMUST00000020463.7
 Ncln
nicalin homolog (zebrafish)
chr7_-_102565425 0.144 ENSMUST00000106913.1
ENSMUST00000033264.4
 Trim21

tripartite motif-containing 21

chr16_-_19706365 0.141 ENSMUST00000081880.5
 Lamp3
lysosomal-associated membrane protein 3
chr11_-_116027961 0.136 ENSMUST00000106454.1
 H3f3b
H3 histone, family 3B
chrX_-_38576166 0.131 ENSMUST00000050083.5
 Cul4b
cullin 4B
chr19_+_6046576 0.126 ENSMUST00000138532.1
ENSMUST00000129081.1
ENSMUST00000156550.1
 Syvn1


synovial apoptosis inhibitor 1, synoviolin


chr9_-_35176039 0.109 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr6_-_54972603 0.085 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr2_-_62646146 0.084 ENSMUST00000112459.3
ENSMUST00000028259.5
 Ifih1

interferon induced with helicase C domain 1

chr16_-_35871544 0.035 ENSMUST00000042665.8
 Parp14
poly (ADP-ribose) polymerase family, member 14
chr16_-_35939082 0.032 ENSMUST00000081933.7
ENSMUST00000114885.1
 Dtx3l

deltex 3-like (Drosophila)

chr7_-_104353328 0.032 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr16_-_38341812 0.028 ENSMUST00000114740.2
ENSMUST00000023501.8
 Maats1

MYCBP-associated, testis expressed 1

chr2_-_105399286 0.023 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr2_-_152332639 0.011 ENSMUST00000028964.7
 Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr19_-_43752924 0.011 ENSMUST00000045562.5
 Cox15
cytochrome c oxidase assembly protein 15

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.5 2.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.3 2.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 0.4 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578)
0.2 0.8 GO:0009597 detection of virus(GO:0009597)
0.2 2.5 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.2 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.4 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 1.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.8 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.3 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 0.5 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.4 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1 0.6 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 1.1 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.1 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.7 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.0 0.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.1 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.3 2.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 0.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 2.8 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 4.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 0.6 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.2 0.7 GO:0050436 microfibril binding(GO:0050436)
0.2 0.5 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.0 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.0 GO:0031386 protein tag(GO:0031386)
0.1 1.9 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.8 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.6 GO:0001948 glycoprotein binding(GO:0001948)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 2.2 GO:0003924 GTPase activity(GO:0003924)