Motif ID: Gtf2i_Gtf2f1

Z-value: 1.953

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314378_1343144240.771.2e-03Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.761.6e-03Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 7.672 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr7_+_36698002 4.589 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr5_-_44799643 4.207 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr7_-_78578308 4.095 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_+_44310213 3.690 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr4_-_123527648 3.489 ENSMUST00000147228.1
 Macf1
microtubule-actin crosslinking factor 1
chr14_-_12345847 3.380 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr4_+_32238950 3.312 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr12_-_27342696 3.215 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr5_+_57718021 3.070 ENSMUST00000094783.3
ENSMUST00000068110.7
 Pcdh7

protocadherin 7

chr6_-_144209471 2.996 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr1_+_178798438 2.991 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr1_-_64121389 2.954 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr12_+_95695350 2.892 ENSMUST00000110117.1
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr10_-_127620922 2.717 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr10_-_127620960 2.697 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr2_-_45112890 2.555 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr19_-_28011138 2.459 ENSMUST00000174850.1
 Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr9_+_70679016 2.446 ENSMUST00000144537.1
 Adam10
a disintegrin and metallopeptidase domain 10
chr8_+_107293500 2.406 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 578 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.8 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 7.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
1.2 7.0 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.4 6.8 GO:2000587 regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.8 6.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.9 5.7 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 5.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 5.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 5.0 GO:0071625 vocalization behavior(GO:0071625)
0.0 4.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.5 4.4 GO:0050975 sensory perception of touch(GO:0050975)
1.5 4.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 4.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 4.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 4.1 GO:0001578 microtubule bundle formation(GO:0001578)
1.3 4.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.0 4.0 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
1.2 3.6 GO:0046959 habituation(GO:0046959)
0.2 3.6 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.4 3.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 10.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 8.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 8.1 GO:0030427 site of polarized growth(GO:0030427)
0.5 7.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 7.6 GO:0043197 dendritic spine(GO:0043197)
0.1 6.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 5.9 GO:0005923 bicellular tight junction(GO:0005923)
0.3 4.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 4.6 GO:0030673 axolemma(GO:0030673)
0.3 3.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 3.5 GO:0032584 growth cone membrane(GO:0032584)
0.0 3.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 3.2 GO:0005883 neurofilament(GO:0005883)
0.2 3.2 GO:0097470 ribbon synapse(GO:0097470)
0.3 3.1 GO:0030057 desmosome(GO:0030057)
0.1 3.0 GO:0005871 kinesin complex(GO:0005871)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.4 2.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 347 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0005096 GTPase activator activity(GO:0005096)
0.4 9.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 8.1 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 8.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.2 6.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 6.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
1.1 5.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.2 5.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.3 4.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 4.7 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.5 4.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 4.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 4.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 4.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.0 3.9 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 3.9 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 3.9 GO:0000287 magnesium ion binding(GO:0000287)
0.1 3.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 3.4 GO:0050321 tau-protein kinase activity(GO:0050321)