Motif ID: Hoxa1

Z-value: 0.849


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_81628702 3.448 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr4_-_143299498 3.261 ENSMUST00000030317.7
 Pdpn
podoplanin
chr9_+_15239045 2.675 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr10_+_81628570 2.185 ENSMUST00000153573.1
ENSMUST00000119336.1
 Ankrd24

ankyrin repeat domain 24

chr2_+_158375638 2.021 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr17_-_25081138 1.955 ENSMUST00000024984.6
 Tmem204
transmembrane protein 204
chr6_-_136875794 1.476 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr14_-_103844173 1.429 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr8_-_11312731 1.403 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr16_+_38902305 1.396 ENSMUST00000023478.7
 Igsf11
immunoglobulin superfamily, member 11
chrX_+_56454871 1.328 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr13_+_31806627 1.028 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr13_-_12340723 1.018 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
 Actn2


actinin alpha 2


chr9_+_65890237 0.905 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr13_-_60177357 0.818 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_-_143299463 0.793 ENSMUST00000119654.1
 Pdpn
podoplanin
chr10_+_79988584 0.768 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr2_+_36230426 0.716 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr10_+_67185730 0.692 ENSMUST00000173689.1
 Jmjd1c
jumonji domain containing 1C
chr3_+_114030532 0.595 ENSMUST00000123619.1
ENSMUST00000092155.5
 Col11a1

collagen, type XI, alpha 1

chr13_-_103764502 0.524 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr5_-_107289561 0.510 ENSMUST00000031224.8
 Tgfbr3
transforming growth factor, beta receptor III
chr9_+_113930934 0.492 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr10_+_75037291 0.486 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr8_-_105484350 0.471 ENSMUST00000044286.5
 Zdhhc1
zinc finger, DHHC domain containing 1
chr1_-_45503282 0.470 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr9_+_58129062 0.386 ENSMUST00000085677.2
 Stra6
stimulated by retinoic acid gene 6
chr4_+_138775735 0.385 ENSMUST00000030528.2
 Pla2g2d
phospholipase A2, group IID
chr9_+_58129321 0.374 ENSMUST00000034880.3
 Stra6
stimulated by retinoic acid gene 6
chr14_+_70077375 0.316 ENSMUST00000035908.1
 Egr3
early growth response 3
chr1_+_10993452 0.315 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr2_-_69885557 0.315 ENSMUST00000060447.6
 Mettl5
methyltransferase like 5
chr2_-_26246707 0.310 ENSMUST00000166349.1
 C030048H21Rik
RIKEN cDNA C030048H21 gene
chr3_-_110143937 0.309 ENSMUST00000051253.3
 Ntng1
netrin G1
chr17_-_90455872 0.292 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr10_+_81628540 0.281 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chr6_+_48395652 0.279 ENSMUST00000077093.4
 Krba1
KRAB-A domain containing 1
chr7_-_127708886 0.277 ENSMUST00000061468.8
 Bcl7c
B cell CLL/lymphoma 7C
chr6_+_48395586 0.273 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
 Krba1


KRAB-A domain containing 1


chr8_-_117673682 0.259 ENSMUST00000173522.1
ENSMUST00000174450.1
 Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr3_+_98013503 0.252 ENSMUST00000079812.6
 Notch2
notch 2
chr1_+_153874335 0.237 ENSMUST00000055314.3
 Gm5531
predicted gene 5531
chr18_+_4994600 0.237 ENSMUST00000140448.1
 Svil
supervillin
chrX_+_110814390 0.212 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chr7_+_144838590 0.211 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr2_+_163225363 0.205 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr5_+_42067960 0.196 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr5_-_123749393 0.184 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
 Rsrc2


arginine/serine-rich coiled-coil 2


chr14_+_56575603 0.181 ENSMUST00000161553.1
 Parp4
poly (ADP-ribose) polymerase family, member 4
chrX_-_75578188 0.173 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr9_-_31464238 0.166 ENSMUST00000048050.7
 Tmem45b
transmembrane protein 45b
chr1_-_119053619 0.164 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr5_-_123749371 0.160 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
 Rsrc2


arginine/serine-rich coiled-coil 2


chr2_-_152951688 0.152 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15
chr5_+_137030275 0.149 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chrX_-_150812932 0.139 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
 Maged2


melanoma antigen, family D, 2


chr4_-_11981265 0.139 ENSMUST00000098260.2
 Gm10604
predicted gene 10604
chrX_-_150813637 0.122 ENSMUST00000112700.1
 Maged2
melanoma antigen, family D, 2
chr11_+_62281457 0.121 ENSMUST00000101075.4
ENSMUST00000050646.6
 Ttc19

tetratricopeptide repeat domain 19

chr13_+_72628802 0.111 ENSMUST00000074372.4
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr16_+_18877037 0.105 ENSMUST00000120532.1
ENSMUST00000004222.7
 Hira

histone cell cycle regulation defective homolog A (S. cerevisiae)

chr10_-_78352469 0.092 ENSMUST00000138035.1
 Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr4_-_108406676 0.088 ENSMUST00000184609.1
 Gpx7
glutathione peroxidase 7
chr16_-_18876655 0.088 ENSMUST00000023391.8
 Mrpl40
mitochondrial ribosomal protein L40
chr2_+_165595009 0.083 ENSMUST00000088132.6
 Eya2
eyes absent 2 homolog (Drosophila)
chr10_+_14523062 0.082 ENSMUST00000096020.5
 Gm10335
predicted gene 10335
chr5_-_135573036 0.080 ENSMUST00000004936.6
 Ccl24
chemokine (C-C motif) ligand 24
chr2_-_131043088 0.074 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr11_-_20332654 0.072 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr10_-_92162753 0.071 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr9_-_101034857 0.064 ENSMUST00000142676.1
ENSMUST00000149322.1
 Pccb

propionyl Coenzyme A carboxylase, beta polypeptide

chr11_+_103774150 0.060 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr16_-_18876522 0.056 ENSMUST00000119273.1
 Mrpl40
mitochondrial ribosomal protein L40
chr5_+_135369942 0.055 ENSMUST00000000940.8
 Nsun5
NOL1/NOP2/Sun domain family, member 5
chr7_+_119690026 0.053 ENSMUST00000047045.8
 Acsm4
acyl-CoA synthetase medium-chain family member 4
chr3_+_58525821 0.047 ENSMUST00000029387.8
 Eif2a
eukaryotic translation initiation factor 2A
chr11_-_102296618 0.047 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr9_+_58129476 0.044 ENSMUST00000133287.1
 Stra6
stimulated by retinoic acid gene 6
chr2_-_131042682 0.044 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr1_-_119053339 0.041 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr6_+_91684061 0.032 ENSMUST00000032185.7
 Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr13_+_72628831 0.018 ENSMUST00000169028.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr5_-_137684665 0.012 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr9_+_59589288 0.008 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr2_-_148045891 0.008 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chr8_+_95825353 0.008 ENSMUST00000074053.4
 Gm10094
predicted gene 10094

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.4 4.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.3 1.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.3 1.0 GO:0051695 actin filament uncapping(GO:0051695)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 1.4 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 0.8 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.2 0.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.6 GO:0035989 tendon development(GO:0035989)
0.1 0.7 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.3 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
0.1 0.9 GO:0019985 translesion synthesis(GO:0019985)
0.1 0.8 GO:0042473 outer ear morphogenesis(GO:0042473)
0.1 0.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 2.0 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.1 0.2 GO:0060032 notochord regression(GO:0060032)
0.0 0.4 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.1 GO:2000416 regulation of eosinophil migration(GO:2000416) positive regulation of eosinophil migration(GO:2000418)
0.0 0.2 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.5 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.3 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 1.5 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.1 GO:0060174 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) limb bud formation(GO:0060174)
0.0 0.1 GO:0043084 penile erection(GO:0043084)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 0.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.9 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 1.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.4 4.1 GO:0008517 folic acid transporter activity(GO:0008517) water channel activity(GO:0015250)
0.1 1.0 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.1 3.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.0 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.3 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.7 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)