Motif ID: Irf5_Irf6

Z-value: 0.839

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6



Activity profile for motif Irf5_Irf6.

activity profile for motif Irf5_Irf6


Sorted Z-values histogram for motif Irf5_Irf6

Sorted Z-values for motif Irf5_Irf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 61 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_141010759 4.486 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr4_-_136886187 2.876 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr6_-_39118211 2.027 ENSMUST00000038398.6
 Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_-_77519565 1.675 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr4_-_40239779 1.519 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_101582236 1.463 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
 Tmem106a



transmembrane protein 106A



chr19_+_55741810 1.104 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr11_-_78984831 1.081 ENSMUST00000073001.4
ENSMUST00000108269.3
 Lgals9

lectin, galactose binding, soluble 9

chr11_+_88999376 0.981 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
 Trim25


tripartite motif-containing 25


chr11_-_78984946 0.819 ENSMUST00000108268.3
 Lgals9
lectin, galactose binding, soluble 9
chr7_+_128523576 0.757 ENSMUST00000033136.7
 Bag3
BCL2-associated athanogene 3
chr9_+_20868628 0.757 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr10_+_80249106 0.716 ENSMUST00000105364.1
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr1_-_75317536 0.707 ENSMUST00000066668.7
 Dnpep
aspartyl aminopeptidase
chr2_-_77170592 0.679 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr10_+_80249441 0.657 ENSMUST00000020361.6
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_+_99979061 0.609 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr9_+_55326913 0.595 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr1_-_163313661 0.586 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr1_-_184732616 0.566 ENSMUST00000048572.6
 Hlx
H2.0-like homeobox

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 2.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.5 2.0 GO:0009597 detection of virus(GO:0009597)
0.6 1.9 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 1.7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 1.4 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 0.6 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 0.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.6 GO:0051642 centrosome localization(GO:0051642)
0.2 0.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.0 0.5 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0045056 transcytosis(GO:0045056)
0.0 0.3 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.1 0.2 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) protein poly-ADP-ribosylation(GO:0070212) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0045177 apical part of cell(GO:0045177)
0.0 2.9 GO:0005581 collagen trimer(GO:0005581)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 1.9 GO:0016936 galactoside binding(GO:0016936)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.1 1.4 GO:0048038 quinone binding(GO:0048038)
0.1 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.0 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0042805 actinin binding(GO:0042805)
0.1 0.4 GO:0030492 hemoglobin binding(GO:0030492)
0.1 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)