Motif ID: Irf5_Irf6

Z-value: 0.839

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_141010759 4.486 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr4_-_136886187 2.876 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr6_-_39118211 2.027 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr2_-_77519565 1.675 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr4_-_40239779 1.519 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_101582236 1.463 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
Tmem106a



transmembrane protein 106A



chr19_+_55741810 1.104 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr11_-_78984831 1.081 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9

chr11_+_88999376 0.981 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr11_-_78984946 0.819 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr7_+_128523576 0.757 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr9_+_20868628 0.757 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr10_+_80249106 0.716 ENSMUST00000105364.1
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr1_-_75317536 0.707 ENSMUST00000066668.7
Dnpep
aspartyl aminopeptidase
chr2_-_77170592 0.679 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr10_+_80249441 0.657 ENSMUST00000020361.6
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_+_99979061 0.609 ENSMUST00000046721.1
4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr9_+_55326913 0.595 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr1_-_163313661 0.586 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr1_-_184732616 0.566 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr1_-_75316998 0.518 ENSMUST00000113605.3
Dnpep
aspartyl aminopeptidase
chrM_+_8600 0.512 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr7_-_141266415 0.496 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr15_+_9436028 0.494 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr3_-_142395661 0.486 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chrX_+_77511002 0.464 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chrM_+_9452 0.463 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr4_-_40239700 0.451 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_45042425 0.444 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr16_+_35938972 0.439 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_69586021 0.405 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr11_+_72301613 0.364 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr9_-_111057235 0.324 ENSMUST00000111888.1
Ccrl2
chemokine (C-C motif) receptor-like 2
chr11_-_86201144 0.314 ENSMUST00000044423.3
Brip1
BRCA1 interacting protein C-terminal helicase 1
chr4_+_108460000 0.267 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr5_-_24447587 0.263 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr15_-_76243401 0.250 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr16_-_67620880 0.246 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr11_+_69966896 0.223 ENSMUST00000151515.1
Cldn7
claudin 7
chr16_+_35938470 0.208 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr5_+_92809372 0.200 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr5_-_45857473 0.192 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
Lcorl


ligand dependent nuclear receptor corepressor-like


chr12_-_31950210 0.184 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr8_-_105568298 0.177 ENSMUST00000005849.5
Agrp
agouti related protein
chr15_+_96287518 0.154 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2

AT rich interactive domain 2 (ARID, RFX-like)

chr16_-_67620805 0.153 ENSMUST00000120594.1
Cadm2
cell adhesion molecule 2
chr9_-_123862023 0.150 ENSMUST00000182350.1
ENSMUST00000078755.2
Xcr1

chemokine (C motif) receptor 1

chr16_-_35871544 0.144 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr2_-_51934644 0.130 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr1_+_175632169 0.112 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_-_31950170 0.105 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr9_-_14381242 0.103 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr17_-_78882508 0.102 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr16_+_23609895 0.090 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr3_+_142496924 0.088 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr7_+_83755904 0.077 ENSMUST00000051522.8
ENSMUST00000042280.7
Gm7964

predicted gene 7964

chr6_-_87838671 0.069 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr17_+_23679363 0.063 ENSMUST00000024699.2
Cldn6
claudin 6
chr12_-_31950535 0.060 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr16_-_5255923 0.034 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr12_-_73113407 0.021 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.5 2.0 GO:0009597 detection of virus(GO:0009597)
0.3 5.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 0.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 2.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.6 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.2 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) protein poly-ADP-ribosylation(GO:0070212) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.4 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.4 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0019441 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.2 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
0.0 0.1 GO:0000389 generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389)
0.0 0.3 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.2 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.6 GO:0051642 centrosome localization(GO:0051642)
0.0 0.5 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.0 GO:0072095 regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0070469 respiratory chain(GO:0070469)
0.0 4.8 GO:0045177 apical part of cell(GO:0045177)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0016936 galactoside binding(GO:0016936)
0.1 3.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 1.4 GO:0048038 quinone binding(GO:0048038)
0.1 0.4 GO:0030492 hemoglobin binding(GO:0030492)
0.1 1.0 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 1.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 2.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.7 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0042805 actinin binding(GO:0042805)