Motif ID: Six6

Z-value: 0.856


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_729397580.175.6e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_57455898 2.601 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr10_+_24595623 1.455 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr7_-_126676428 1.443 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr7_-_126676357 1.362 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr15_-_75894474 1.305 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr11_+_78324200 1.259 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chrX_-_142966709 1.248 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_+_98571004 1.217 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr17_+_43568269 1.207 ENSMUST00000024706.5
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chrX_+_169685191 1.204 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr5_+_140607334 1.162 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_17316078 1.077 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr13_+_94083490 1.074 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr17_+_43568641 1.068 ENSMUST00000169694.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr19_-_11336107 1.044 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr1_-_165708088 1.009 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr13_+_65512678 0.932 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chrX_+_103414461 0.889 ENSMUST00000033691.4
 Tsx
testis specific X-linked gene
chr17_+_43568096 0.859 ENSMUST00000167214.1
 Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr3_-_85887472 0.856 ENSMUST00000033643.5
ENSMUST00000154148.1
 Glt28d2
Arfip1
glycosyltransferase 28 domain containing 2
ADP-ribosylation factor interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.8 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 2.8 GO:0051923 sulfation(GO:0051923)
0.0 2.5 GO:0009566 fertilization(GO:0009566)
0.4 1.5 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 1.2 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.1 GO:0003351 epithelial cilium movement(GO:0003351)
0.2 1.0 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.2 1.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 1.0 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.9 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.2 0.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.8 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.8 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 0.7 GO:0048539 bone marrow development(GO:0048539)
0.2 0.7 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.7 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 2.6 GO:0044306 neuron projection terminus(GO:0044306)
0.0 2.2 GO:0005801 cis-Golgi network(GO:0005801)
0.2 1.0 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 0.8 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.8 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.7 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.4 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232) dense body(GO:0097433)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.1 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.8 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.9 2.8 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 1.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 1.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 1.0 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.7 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.7 GO:0019841 retinol binding(GO:0019841)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.2 0.6 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.6 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)