Motif ID: Tbr1

Z-value: 1.810


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.687.8e-03Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_111733924 6.753 ENSMUST00000180627.1
 Gm26897
predicted gene, 26897
chr2_+_71528657 5.705 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr3_+_95526777 4.396 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr11_-_120731944 4.227 ENSMUST00000154565.1
ENSMUST00000026148.2
 Cbr2

carbonyl reductase 2

chr7_+_30413744 4.161 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr2_+_71529085 3.972 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr10_+_57784859 3.760 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr2_-_71546745 3.457 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr7_-_19698206 3.414 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr11_-_32222233 3.392 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chrY_+_897782 3.304 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr13_+_56609516 3.292 ENSMUST00000045173.8
 Tgfbi
transforming growth factor, beta induced
chr9_-_123678782 3.171 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr6_+_124304646 3.114 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr1_-_171059390 3.094 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr12_+_85473883 2.886 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr11_-_69900949 2.857 ENSMUST00000102580.3
 2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr11_+_82035569 2.821 ENSMUST00000000193.5
 Ccl2
chemokine (C-C motif) ligand 2
chr11_+_3514861 2.789 ENSMUST00000094469.4
 Selm
selenoprotein M
chr10_-_120899067 2.758 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 13.1 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 6.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.3 5.9 GO:0060134 prepulse inhibition(GO:0060134)
1.0 5.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
1.5 4.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 4.4 GO:0010447 response to acidic pH(GO:0010447)
1.4 4.2 GO:0006116 NADH oxidation(GO:0006116)
0.8 4.2 GO:2001204 regulation of osteoclast development(GO:2001204)
0.1 4.0 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.9 3.8 GO:0035934 corticosterone secretion(GO:0035934)
0.7 3.7 GO:0030091 protein repair(GO:0030091)
1.1 3.4 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.7 3.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.1 3.2 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.1 3.2 GO:0036233 glycine import(GO:0036233)
1.0 3.1 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.2 3.1 GO:0006953 acute-phase response(GO:0006953)
0.2 3.0 GO:0042428 serotonin metabolic process(GO:0042428)
0.2 2.9 GO:0035994 response to muscle stretch(GO:0035994)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)
0.5 6.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 6.4 GO:0005604 basement membrane(GO:0005604)
0.0 3.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.1 3.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.3 3.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 3.0 GO:0000124 SAGA complex(GO:0000124)
0.9 2.8 GO:0044299 C-fiber(GO:0044299)
0.6 2.8 GO:0097441 basilar dendrite(GO:0097441)
0.0 2.8 GO:0030027 lamellipodium(GO:0030027)
0.2 2.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 2.6 GO:0001772 immunological synapse(GO:0001772)
0.1 2.5 GO:0005605 basal lamina(GO:0005605)
0.2 2.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 2.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 2.0 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.9 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 6.6 GO:0003682 chromatin binding(GO:0003682)
0.2 4.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 4.6 GO:0005096 GTPase activator activity(GO:0005096)
1.0 4.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 4.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 4.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 3.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 3.7 GO:0005518 collagen binding(GO:0005518)
0.5 3.6 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.2 3.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 3.5 GO:0005504 fatty acid binding(GO:0005504)
1.1 3.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 3.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 3.3 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.3 3.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.3 GO:0019905 syntaxin binding(GO:0019905)
0.5 3.2 GO:0016936 galactoside binding(GO:0016936)
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.0 3.1 GO:0019770 IgG receptor activity(GO:0019770)