Motif ID: Hoxb5

Z-value: 0.833


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_63927434 1.972 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr3_-_103737995 1.802 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chrX_-_60893430 1.675 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr4_+_11704439 1.266 ENSMUST00000108304.2
Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chrX_-_165327376 1.235 ENSMUST00000058787.8
Glra2
glycine receptor, alpha 2 subunit
chr4_-_131821516 1.085 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr17_+_31386218 1.073 ENSMUST00000047168.5
Pde9a
phosphodiesterase 9A
chr17_+_31386244 1.029 ENSMUST00000134525.1
ENSMUST00000127929.1
Pde9a

phosphodiesterase 9A

chr7_-_119895697 1.002 ENSMUST00000059851.6
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_+_126103940 0.965 ENSMUST00000116286.2
ENSMUST00000094761.4
ENSMUST00000139524.1
Stk40


serine/threonine kinase 40


chrX_-_72656135 0.911 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr4_+_86053887 0.870 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
Adamtsl1



ADAMTS-like 1



chr7_+_3390629 0.813 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr12_-_78980758 0.810 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr4_-_141874879 0.781 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr2_+_158667119 0.766 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr10_-_62143906 0.717 ENSMUST00000141724.1
ENSMUST00000150057.1
2010107G23Rik

RIKEN cDNA 2010107G23 gene

chr9_-_35558522 0.676 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr7_-_119896285 0.609 ENSMUST00000106519.1
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_+_14864076 0.582 ENSMUST00000029875.3
Tmem55a
transmembrane protein 55A
chr11_+_4873951 0.566 ENSMUST00000038570.2
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr14_-_63543931 0.565 ENSMUST00000058679.5
Mtmr9
myotubularin related protein 9
chr7_-_133709051 0.502 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros

uroporphyrinogen III synthase

chr1_-_193370260 0.499 ENSMUST00000016323.4
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr17_+_35077080 0.494 ENSMUST00000172959.1
Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr2_+_152962485 0.485 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr1_-_193370225 0.480 ENSMUST00000169907.1
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr7_+_119895836 0.462 ENSMUST00000106518.1
ENSMUST00000054440.3
Lyrm1

LYR motif containing 1

chr17_+_47630690 0.451 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr12_-_78983476 0.429 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr8_+_123332676 0.426 ENSMUST00000010298.6
Spire2
spire homolog 2 (Drosophila)
chr7_-_127208423 0.411 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chr4_-_52497244 0.410 ENSMUST00000114578.4
Vma21-ps
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
chr10_-_81014902 0.402 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chrX_-_48454152 0.400 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr7_-_133709069 0.390 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr2_-_130629994 0.382 ENSMUST00000028761.4
ENSMUST00000110262.1
Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr7_+_119896292 0.356 ENSMUST00000106517.1
Lyrm1
LYR motif containing 1
chr7_-_133708958 0.347 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr18_-_61707583 0.341 ENSMUST00000025472.1
Pcyox1l
prenylcysteine oxidase 1 like
chr17_+_47593516 0.336 ENSMUST00000182874.1
Ccnd3
cyclin D3
chr8_+_85840971 0.332 ENSMUST00000053771.7
ENSMUST00000161850.1
Phkb

phosphorylase kinase beta

chr11_-_96075581 0.324 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr8_-_85840877 0.321 ENSMUST00000034140.7
Itfg1
integrin alpha FG-GAP repeat containing 1
chr7_-_45466894 0.315 ENSMUST00000033093.8
Bax
BCL2-associated X protein
chr3_+_67374116 0.300 ENSMUST00000061322.8
Mlf1
myeloid leukemia factor 1
chr9_-_35116804 0.299 ENSMUST00000034537.6
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chrX_-_8193387 0.289 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr13_+_93304066 0.280 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr4_+_123233556 0.274 ENSMUST00000040821.4
Heyl
hairy/enhancer-of-split related with YRPW motif-like
chr15_+_12205009 0.270 ENSMUST00000038172.8
Mtmr12
myotubularin related protein 12
chr1_-_166409773 0.267 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk




pogo transposable element with KRAB domain




chr9_+_4383535 0.256 ENSMUST00000047173.9
Msantd4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chrX_-_10117597 0.250 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
Srpx


sushi-repeat-containing protein


chr16_+_17070127 0.245 ENSMUST00000115729.1
Ypel1
yippee-like 1 (Drosophila)
chr2_+_102659213 0.240 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_164249233 0.216 ENSMUST00000169394.1
Slc19a2
solute carrier family 19 (thiamine transporter), member 2
chr14_+_55559993 0.210 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr11_+_97798995 0.196 ENSMUST00000143571.1
Lasp1
LIM and SH3 protein 1
chr5_-_24527276 0.193 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr2_+_26973416 0.187 ENSMUST00000014996.7
ENSMUST00000102891.3
Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr6_-_128362812 0.185 ENSMUST00000112152.1
ENSMUST00000057421.8
ENSMUST00000112151.1
Rhno1


RAD9-HUS1-RAD1 interacting nuclear orphan 1


chr17_+_35076902 0.184 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr16_+_17070220 0.181 ENSMUST00000141959.1
Ypel1
yippee-like 1 (Drosophila)
chr17_+_57105385 0.178 ENSMUST00000039490.7
Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr8_+_70594466 0.173 ENSMUST00000019283.9
Isyna1
myo-inositol 1-phosphate synthase A1
chr7_-_31150981 0.172 ENSMUST00000085636.6
ENSMUST00000001280.7
Gramd1a

GRAM domain containing 1A

chr1_-_74544275 0.170 ENSMUST00000044260.4
Usp37
ubiquitin specific peptidase 37
chr1_+_74771886 0.163 ENSMUST00000006716.6
Wnt6
wingless-related MMTV integration site 6
chr15_-_28025834 0.159 ENSMUST00000090247.5
Trio
triple functional domain (PTPRF interacting)
chr2_+_85136355 0.154 ENSMUST00000057019.7
Aplnr
apelin receptor
chrX_+_7822289 0.154 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr2_-_167062607 0.143 ENSMUST00000128676.1
Znfx1
zinc finger, NFX1-type containing 1
chr3_+_67374091 0.133 ENSMUST00000077916.5
Mlf1
myeloid leukemia factor 1
chr16_+_17070281 0.133 ENSMUST00000090199.3
Ypel1
yippee-like 1 (Drosophila)
chr8_-_25597459 0.125 ENSMUST00000079160.6
Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr7_+_19004047 0.117 ENSMUST00000053713.3
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr1_-_78511963 0.110 ENSMUST00000170511.1
BC035947
cDNA sequence BC035947
chr10_+_80300997 0.108 ENSMUST00000140828.1
ENSMUST00000138909.1
Apc2

adenomatosis polyposis coli 2

chr6_+_86438360 0.100 ENSMUST00000050497.7
C87436
expressed sequence C87436
chr10_-_127211528 0.098 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr11_-_96075655 0.098 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr14_+_32159865 0.087 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
Ncoa4


nuclear receptor coactivator 4


chr4_-_108848619 0.082 ENSMUST00000164855.1
A730015C16Rik
RIKEN cDNA A730015C16 gene
chr17_+_94873986 0.070 ENSMUST00000108007.4
Gm20939
predicted gene, 20939
chr14_+_55560010 0.061 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr17_+_47593444 0.033 ENSMUST00000182209.1
Ccnd3
cyclin D3
chr11_-_90002881 0.029 ENSMUST00000020864.8
Pctp
phosphatidylcholine transfer protein
chr5_-_137786651 0.019 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr12_+_116275386 0.007 ENSMUST00000090195.4
Gm11027
predicted gene 11027
chr11_+_119229092 0.005 ENSMUST00000053440.7
Ccdc40
coiled-coil domain containing 40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.2 0.8 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.2 1.2 GO:0071361 cellular response to zinc ion(GO:0071294) cellular response to ethanol(GO:0071361)
0.1 0.4 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.1 0.4 GO:0001866 NK T cell proliferation(GO:0001866)
0.1 2.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.3 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1 1.7 GO:0007530 sex determination(GO:0007530)
0.1 1.6 GO:0010225 response to UV-C(GO:0010225)
0.1 0.3 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 0.3 GO:2000823 regulation of androgen receptor activity(GO:2000823)
0.1 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.2 GO:0015888 thiamine transport(GO:0015888)
0.0 0.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.4 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.4 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.0 GO:0003016 respiratory system process(GO:0003016)
0.0 0.2 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 1.3 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.4 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0033391 chromatoid body(GO:0033391)
0.1 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.4 GO:0043204 perikaryon(GO:0043204)
0.0 0.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 0.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 1.2 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.2 0.6 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 2.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.2 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.6 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)