Motif ID: Trp63

Z-value: 0.857


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_108003414 6.127 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr12_-_108003594 5.605 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr13_+_12702362 2.380 ENSMUST00000104944.2
 Gm2399
predicted gene 2399
chr8_-_87959560 1.320 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr5_-_5265224 1.133 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr8_-_31918203 1.093 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr10_-_80671976 1.044 ENSMUST00000003433.6
 Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr11_-_95699143 0.903 ENSMUST00000062249.2
 Gm9796
predicted gene 9796
chr5_+_142401484 0.894 ENSMUST00000072837.5
 Foxk1
forkhead box K1
chr10_-_61452658 0.825 ENSMUST00000167087.1
ENSMUST00000020288.7
 Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr3_-_108402589 0.800 ENSMUST00000147565.1
 Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr4_+_150855064 0.745 ENSMUST00000030811.1
 Errfi1
ERBB receptor feedback inhibitor 1
chr7_-_141443314 0.721 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr11_-_106487833 0.697 ENSMUST00000106801.1
 Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr17_-_6449571 0.606 ENSMUST00000180035.1
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr2_+_25054396 0.585 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chrX_+_159255919 0.497 ENSMUST00000112492.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr11_-_106487796 0.497 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
 Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr7_-_126160992 0.484 ENSMUST00000164741.1
 Xpo6
exportin 6
chr5_-_5266038 0.484 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr8_-_85432841 0.456 ENSMUST00000047749.5
 4921524J17Rik
RIKEN cDNA 4921524J17 gene
chr11_-_69948145 0.341 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
 Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr14_-_54877532 0.333 ENSMUST00000168622.1
ENSMUST00000177403.1
 Ppp1r3e

protein phosphatase 1, regulatory (inhibitor) subunit 3E

chr8_+_84686300 0.327 ENSMUST00000177531.1
 Trmt1
tRNA methyltransferase 1
chrX_+_159255782 0.266 ENSMUST00000126686.1
ENSMUST00000033671.6
 Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr4_-_96591555 0.263 ENSMUST00000055693.8
 Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr19_+_53140430 0.263 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr7_-_114254659 0.211 ENSMUST00000033012.7
 Copb1
coatomer protein complex, subunit beta 1
chr1_-_9700209 0.170 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr7_-_65370908 0.169 ENSMUST00000032729.6
 Tjp1
tight junction protein 1
chr5_-_92083667 0.122 ENSMUST00000113127.3
 G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr2_+_119972699 0.109 ENSMUST00000066058.7
 Mapkbp1
mitogen-activated protein kinase binding protein 1
chr2_-_12301914 0.070 ENSMUST00000028106.4
 Itga8
integrin alpha 8
chr5_-_92083455 0.049 ENSMUST00000169094.1
ENSMUST00000167918.1
 G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr2_-_104494400 0.043 ENSMUST00000028600.7
 Hipk3
homeodomain interacting protein kinase 3
chr11_+_98863610 0.038 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr19_-_5875268 0.012 ENSMUST00000025728.6
 Frmd8
FERM domain containing 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 11.7 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.2 0.7 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 1.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.2 1.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 0.8 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.3 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 1.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.6 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.8 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.3 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 1.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 1.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 1.2 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.1 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 1.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 11.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)