Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 1.247

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elk4mm10_v2_chr1_+_132008285_1320083160.592.7e-02Click!
Elk3mm10_v2_chr10_-_93310963_93310989-0.582.9e-02Click!
Etv3mm10_v2_chr3_+_87525572_875256430.117.0e-01Click!
Elk1mm10_v2_chrX_-_20950597_209506130.068.4e-01Click!
Erfmm10_v2_chr7_-_25250720_252507610.048.8e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_42182924 1.748 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr19_-_28011138 1.721 ENSMUST00000174850.1
 Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr12_-_64965496 1.710 ENSMUST00000021331.7
 Klhl28
kelch-like 28
chrX_-_12762069 1.697 ENSMUST00000096495.4
ENSMUST00000076016.5
 Med14

mediator complex subunit 14

chr16_-_87432597 1.692 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr5_-_3803081 1.672 ENSMUST00000043551.6
 Ankib1
ankyrin repeat and IBR domain containing 1
chr2_+_5845243 1.585 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr11_-_104550392 1.567 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr5_+_122391878 1.559 ENSMUST00000102525.4
 Arpc3
actin related protein 2/3 complex, subunit 3
chr14_+_75284343 1.551 ENSMUST00000022577.5
 Zc3h13
zinc finger CCCH type containing 13
chr4_-_122886044 1.525 ENSMUST00000106255.1
ENSMUST00000106257.3
 Cap1

CAP, adenylate cyclase-associated protein 1 (yeast)

chr11_+_83299005 1.471 ENSMUST00000176944.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr8_-_9977650 1.452 ENSMUST00000170033.1
 Lig4
ligase IV, DNA, ATP-dependent
chr9_+_27299205 1.427 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr2_+_164805082 1.401 ENSMUST00000052107.4
 Zswim3
zinc finger SWIM-type containing 3
chr7_-_119793958 1.401 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
 Eri2


exoribonuclease 2


chr12_+_64965742 1.375 ENSMUST00000066296.7
 Fam179b
family with sequence similarity 179, member B
chr1_-_36244245 1.337 ENSMUST00000046875.7
 Uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_-_120364344 1.301 ENSMUST00000146667.1
 Ccdc77
coiled-coil domain containing 77
chr4_-_122885965 1.293 ENSMUST00000128485.1
 Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 324 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0006352 DNA-templated transcription, initiation(GO:0006352)
0.1 3.5 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 3.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 2.8 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.4 2.6 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 2.6 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.1 2.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 2.4 GO:0003281 ventricular septum development(GO:0003281)
0.1 2.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 2.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.0 GO:0045116 protein neddylation(GO:0045116)
0.1 2.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.6 1.9 GO:0019085 early viral transcription(GO:0019085)
0.0 1.9 GO:0048278 vesicle docking(GO:0048278)
0.3 1.8 GO:0009249 protein lipoylation(GO:0009249)
0.3 1.8 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.4 1.7 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.4 1.7 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.3 1.7 GO:0021764 amygdala development(GO:0021764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0005813 centrosome(GO:0005813)
0.0 4.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 3.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 3.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 2.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 2.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 2.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 2.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 2.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 1.8 GO:1990745 EARP complex(GO:1990745)
0.3 1.7 GO:0070847 core mediator complex(GO:0070847)
0.2 1.7 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.2 1.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.7 GO:0005675 holo TFIIH complex(GO:0005675)
0.3 1.6 GO:0097427 microtubule bundle(GO:0097427)
0.2 1.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 3.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 3.6 GO:0003924 GTPase activity(GO:0003924)
0.2 3.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 2.8 GO:0008134 transcription factor binding(GO:0008134)
0.4 2.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 2.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.5 2.4 GO:0071253 connexin binding(GO:0071253)
0.0 2.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 2.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 2.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.1 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.1 2.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 2.0 GO:0051018 protein kinase A binding(GO:0051018)
0.1 1.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)