Motif ID: E2f1

Z-value: 2.095


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569845_1545698920.798.0e-04Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_90784738 11.549 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chrX_+_170009892 11.007 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chrX_+_170009659 10.040 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr10_+_80356459 6.090 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr14_-_79301623 5.410 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr13_-_47106176 4.016 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr11_+_50602072 3.864 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr4_-_59549314 3.841 ENSMUST00000148331.2
ENSMUST00000030076.5
 Ptbp3

polypyrimidine tract binding protein 3

chr13_+_94057757 3.826 ENSMUST00000054274.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chrY_+_90785442 3.801 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr18_+_65873478 3.763 ENSMUST00000025395.8
ENSMUST00000173530.1
 Grp

gastrin releasing peptide

chr13_+_117602439 3.707 ENSMUST00000006991.7
 Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
chr14_-_103843685 3.382 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr13_-_47105790 3.215 ENSMUST00000129352.1
 Dek
DEK oncogene (DNA binding)
chr12_-_76709997 3.210 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chr2_+_78869009 3.201 ENSMUST00000028398.7
 Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr2_+_71528657 3.194 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr4_-_59549243 3.143 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
 Ptbp3



polypyrimidine tract binding protein 3



chr5_-_134747241 3.101 ENSMUST00000015138.9
 Eln
elastin
chr6_+_86526271 3.062 ENSMUST00000180896.1
 1600020E01Rik
RIKEN cDNA 1600020E01 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 398 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.5 GO:0035019 somatic stem cell population maintenance(GO:0035019)
1.7 7.0 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.5 7.0 GO:0043249 erythrocyte maturation(GO:0043249)
1.5 5.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
1.9 5.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.8 5.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.7 5.6 GO:0002347 response to tumor cell(GO:0002347)
0.2 5.1 GO:0006270 DNA replication initiation(GO:0006270)
0.5 4.7 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 4.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 4.4 GO:0021516 dorsal spinal cord development(GO:0021516)
0.7 4.2 GO:0035989 tendon development(GO:0035989)
0.2 3.9 GO:0030574 collagen catabolic process(GO:0030574)
0.2 3.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.2 3.7 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
1.2 3.6 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.2 3.5 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.9 3.5 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.3 3.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 3.5 GO:0010457 centriole-centriole cohesion(GO:0010457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 173 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0000785 chromatin(GO:0000785)
0.3 5.2 GO:0042555 MCM complex(GO:0042555)
0.2 5.0 GO:0060077 inhibitory synapse(GO:0060077)
0.0 4.4 GO:0001726 ruffle(GO:0001726)
0.0 4.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.3 GO:0005581 collagen trimer(GO:0005581)
0.7 4.1 GO:0008091 spectrin(GO:0008091)
0.5 4.0 GO:0098536 deuterosome(GO:0098536)
0.1 4.0 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.3 3.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 3.8 GO:0005814 centriole(GO:0005814)
0.1 3.7 GO:0032590 dendrite membrane(GO:0032590)
0.9 3.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
1.2 3.5 GO:0000802 transverse filament(GO:0000802)
1.0 3.1 GO:0071953 elastic fiber(GO:0071953)
0.8 3.1 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.4 3.1 GO:0000796 condensin complex(GO:0000796)
0.3 3.1 GO:0001739 sex chromatin(GO:0001739)
0.1 3.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 3.0 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.8 GO:0042393 histone binding(GO:0042393)
0.3 10.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 10.3 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 6.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 5.4 GO:0030506 ankyrin binding(GO:0030506)
0.2 5.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 4.6 GO:0003729 mRNA binding(GO:0003729)
0.6 4.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.7 3.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 3.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.2 3.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.1 3.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 3.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 3.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 3.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.1 GO:0005507 copper ion binding(GO:0005507)
0.4 3.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)