Motif ID: Tlx2

Z-value: 1.319


Transcription factors associated with Tlx2:

Gene SymbolEntrez IDGene Name
Tlx2 ENSMUSG00000068327.3 Tlx2



Activity profile for motif Tlx2.

activity profile for motif Tlx2


Sorted Z-values histogram for motif Tlx2

Sorted Z-values for motif Tlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91225550 4.578 ENSMUST00000035608.8
 Olig2
oligodendrocyte transcription factor 2
chr8_+_65618009 2.651 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
 March1


membrane-associated ring finger (C3HC4) 1


chr1_-_190170671 2.271 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr6_+_108660772 2.075 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr1_-_87156127 2.056 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr19_-_24031006 2.051 ENSMUST00000096164.4
 Fam189a2
family with sequence similarity 189, member A2
chr9_-_123678782 2.040 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr3_-_96293953 2.023 ENSMUST00000029748.3
 Fcgr1
Fc receptor, IgG, high affinity I
chr9_+_111311674 2.015 ENSMUST00000078626.3
 Trank1
tetratricopeptide repeat and ankyrin repeat containing 1
chr19_-_28680077 1.923 ENSMUST00000162022.1
ENSMUST00000112612.2
 Glis3

GLIS family zinc finger 3

chr13_-_23430826 1.840 ENSMUST00000153753.1
ENSMUST00000141543.1
 C230035I16Rik

RIKEN cDNA C230035I16 gene

chr6_-_12749193 1.824 ENSMUST00000046121.6
ENSMUST00000172356.1
 Thsd7a

thrombospondin, type I, domain containing 7A

chr16_-_36666067 1.818 ENSMUST00000089620.4
 Cd86
CD86 antigen
chr8_+_104340594 1.802 ENSMUST00000034343.4
 Cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr9_-_21037775 1.669 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr9_-_123678873 1.616 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr6_+_108660616 1.615 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chrX_+_10485121 1.599 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr4_-_128962420 1.577 ENSMUST00000119354.1
ENSMUST00000106068.1
ENSMUST00000030581.3
 Adc


arginine decarboxylase


chr10_+_61171954 1.533 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 4.3 GO:0009648 photoperiodism(GO:0009648)
0.6 3.7 GO:0036233 glycine import(GO:0036233)
0.1 2.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.8 2.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 2.3 GO:0007601 visual perception(GO:0007601)
0.6 2.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 2.2 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.1 GO:0003016 respiratory system process(GO:0003016)
0.7 2.0 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.6 1.9 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.3 1.8 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 1.8 GO:0071281 ferrous iron transport(GO:0015684) cellular response to iron ion(GO:0071281)
0.0 1.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.4 1.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 1.5 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.2 1.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 1.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 1.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 1.5 GO:0048515 spermatid differentiation(GO:0048515)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 1.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.7 GO:0043205 fibril(GO:0043205)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.4 GO:0005771 multivesicular body(GO:0005771)
0.2 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 1.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 4.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 3.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.6 3.7 GO:0043426 MRF binding(GO:0043426)
0.1 2.7 GO:0042287 MHC protein binding(GO:0042287)
0.3 2.3 GO:0050693 LBD domain binding(GO:0050693)
0.7 2.0 GO:0019770 IgG receptor activity(GO:0019770)
0.3 1.9 GO:0016936 galactoside binding(GO:0016936)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 1.7 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.5 GO:0005125 cytokine activity(GO:0005125)
0.2 1.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)