Motif ID: Tead3_Tead4

Z-value: 1.545

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350747_283508200.525.5e-02Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_6386598 10.739 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr10_+_24595434 8.514 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr10_+_24595623 8.196 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr6_+_121300227 4.636 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr11_-_100970887 4.557 ENSMUST00000060792.5
 Ptrf
polymerase I and transcript release factor
chr1_+_43730593 4.187 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr7_-_19698206 3.196 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr15_+_78842632 2.906 ENSMUST00000059619.1
 Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr1_+_51289106 2.669 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr9_+_69454066 2.579 ENSMUST00000134907.1
 Anxa2
annexin A2
chr11_-_32222233 2.469 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr18_-_35722330 2.342 ENSMUST00000133064.1
 Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr2_-_164857542 2.270 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
 Pltp



phospholipid transfer protein



chr7_-_19698383 2.181 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr3_-_145649970 2.172 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr12_-_80112998 2.134 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr19_-_12765447 2.064 ENSMUST00000112933.1
 Cntf
ciliary neurotrophic factor
chr13_-_113046357 1.963 ENSMUST00000022282.3
 Gpx8
glutathione peroxidase 8 (putative)
chr9_+_69453620 1.936 ENSMUST00000034756.8
ENSMUST00000123470.1
 Anxa2

annexin A2

chr6_-_35308110 1.904 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 16.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
2.1 10.7 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
1.8 5.4 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.7 4.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363)
0.8 4.5 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.5 4.2 GO:0070314 G1 to G0 transition(GO:0070314)
1.0 3.9 GO:0042360 vitamin E metabolic process(GO:0042360)
0.2 3.9 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 3.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.4 2.6 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.5 2.4 GO:0048143 astrocyte activation(GO:0048143)
0.0 2.4 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 2.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.7 2.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.7 2.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 2.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 2.1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 2.0 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 2.0 GO:0007050 cell cycle arrest(GO:0007050)
0.6 1.9 GO:1902358 sulfate transmembrane transport(GO:1902358)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.6 GO:0005801 cis-Golgi network(GO:0005801)
2.7 10.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 10.4 GO:0005901 caveola(GO:0005901)
1.8 5.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 5.4 GO:0005667 transcription factor complex(GO:0005667)
1.5 4.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 4.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.0 3.1 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 2.6 GO:0005902 microvillus(GO:0005902)
0.7 2.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.2 GO:0031985 Golgi cisterna(GO:0031985)
0.2 1.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.1 GO:0098536 deuterosome(GO:0098536)
0.1 1.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.0 0.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.2 10.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
1.8 5.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 5.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.5 4.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.8 4.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
1.1 4.5 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 3.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 3.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 1.9 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.9 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 1.7 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 1.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)