Motif ID: Esr1

Z-value: 0.929


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_4710166-0.488.2e-02Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 1.335 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr5_-_122697603 1.115 ENSMUST00000071235.4
 Gm10064
predicted gene 10064
chr2_+_172549581 0.857 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr15_-_93595877 0.793 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr17_-_87282793 0.779 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr19_+_58728887 0.761 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr13_-_66852017 0.729 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr19_-_41743665 0.716 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr9_+_48495345 0.643 ENSMUST00000048824.7
 Gm5617
predicted gene 5617
chr5_-_147076482 0.561 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr8_+_70072896 0.557 ENSMUST00000110160.2
ENSMUST00000049197.5
 Tm6sf2

transmembrane 6 superfamily member 2

chr2_+_172550991 0.551 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr3_+_104638658 0.508 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr2_-_30801698 0.499 ENSMUST00000050003.8
 1700001O22Rik
RIKEN cDNA 1700001O22 gene
chr12_+_76533540 0.486 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_35175995 0.482 ENSMUST00000173324.1
 Aif1
allograft inflammatory factor 1
chr14_-_30607808 0.467 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr14_-_30626196 0.457 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr16_+_23107413 0.453 ENSMUST00000023599.6
ENSMUST00000168891.1
 Eif4a2

eukaryotic translation initiation factor 4A2

chr7_-_142656018 0.434 ENSMUST00000178921.1
 Igf2
insulin-like growth factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.4 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 1.3 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.2 0.9 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.3 0.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 0.7 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 0.6 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.6 GO:0048821 erythrocyte development(GO:0048821)
0.2 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.5 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.5 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.1 0.4 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.1 0.4 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.1 0.4 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 0.4 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.4 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.4 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.6 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.6 GO:0097452 GAIT complex(GO:0097452)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.5 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.4 1.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 1.2 GO:0070976 TIR domain binding(GO:0070976)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.7 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 0.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)