Motif ID: Gli2

Z-value: 0.536


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_119053638-0.411.5e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_71095765 0.768 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr1_+_55406163 0.663 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr12_+_58211772 0.633 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr17_-_83631892 0.604 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_-_114801364 0.488 ENSMUST00000061632.7
 Trhde
TRH-degrading enzyme
chr4_+_36952930 0.472 ENSMUST00000144029.1
 Gm12371
predicted gene 12371
chr8_+_76902277 0.471 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr18_-_35215008 0.454 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr12_+_38780284 0.424 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_+_69897255 0.405 ENSMUST00000131553.1
 Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr6_-_137649211 0.398 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr2_+_121955964 0.387 ENSMUST00000036647.6
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr9_-_95750335 0.370 ENSMUST00000053785.3
 Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr2_-_104712122 0.359 ENSMUST00000111118.1
ENSMUST00000028597.3
 Tcp11l1

t-complex 11 like 1

chr10_+_76531593 0.356 ENSMUST00000048678.6
 Lss
lanosterol synthase
chr2_+_140395309 0.348 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
 Macrod2





MACRO domain containing 2





chr7_-_137314394 0.348 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr7_-_116308241 0.345 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr2_+_121956411 0.340 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr10_+_83543941 0.339 ENSMUST00000038388.5
 A230046K03Rik
RIKEN cDNA A230046K03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.9 GO:0003383 apical constriction(GO:0003383)
0.1 0.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.6 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:0046541 saliva secretion(GO:0046541)
0.0 0.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.3 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.3 GO:0032897 negative regulation of viral transcription(GO:0032897)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0033269 internode region of axon(GO:0033269)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.2 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.0 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.2 0.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.4 GO:0031559 oxidosqualene cyclase activity(GO:0031559)
0.1 0.3 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 0.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)