Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 1.559

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892619_738926390.874.9e-05Click!
Ezh2mm10_v2_chr6_-_47594967_475950470.332.6e-01Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_190170671 5.279 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr13_+_105443693 3.340 ENSMUST00000022235.4
 Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
chr9_-_117252450 2.827 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr17_-_90455872 2.394 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr10_-_102490418 2.253 ENSMUST00000020040.3
 Nts
neurotensin
chr4_-_82505749 2.119 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr14_-_98169542 2.032 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr6_+_34746368 1.928 ENSMUST00000142716.1
 Cald1
caldesmon 1
chr1_-_190170178 1.845 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr4_-_82505707 1.794 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr11_-_94297067 1.722 ENSMUST00000132623.2
 Luc7l3
LUC7-like 3 (S. cerevisiae)
chr13_+_54371340 1.431 ENSMUST00000026985.8
 Cplx2
complexin 2
chr4_-_110287479 1.327 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr4_-_110290884 1.303 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_-_84525514 1.301 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr2_-_66410064 1.258 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chrX_+_41401304 1.250 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrY_+_897782 1.239 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_-_91365756 1.231 ENSMUST00000034927.6
 Zic1
zinc finger protein of the cerebellum 1
chr16_+_42907563 1.216 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 325 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 5.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 4.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 4.2 GO:1900006 positive regulation of dendrite development(GO:1900006)
1.0 4.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 3.8 GO:0045727 positive regulation of translation(GO:0045727)
0.7 3.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 3.5 GO:0001919 regulation of receptor recycling(GO:0001919)
1.1 3.3 GO:0007210 serotonin receptor signaling pathway(GO:0007210)
0.1 3.3 GO:0008542 visual learning(GO:0008542)
0.0 2.2 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.7 2.1 GO:0060067 cervix development(GO:0060067)
0.0 2.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.7 2.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 1.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 1.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.4 GO:0006940 regulation of smooth muscle contraction(GO:0006940)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0042734 presynaptic membrane(GO:0042734)
0.2 3.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 3.6 GO:0042788 polysomal ribosome(GO:0042788)
0.2 3.4 GO:0043203 axon hillock(GO:0043203)
0.3 3.0 GO:0030478 actin cap(GO:0030478)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0044306 neuron projection terminus(GO:0044306)
0.2 2.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.2 1.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.7 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.4 1.4 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3 1.2 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.1 1.1 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.5 GO:0050693 LBD domain binding(GO:0050693)
0.0 5.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.8 3.3 GO:0051378 serotonin binding(GO:0051378)
0.3 3.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 2.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 2.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.2 GO:0003729 mRNA binding(GO:0003729)
0.7 2.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.7 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.7 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 1.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.4 1.3 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 1.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)