Motif ID: E2f6

Z-value: 0.760


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.263.8e-01Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_44173271 0.777 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr11_+_85832551 0.744 ENSMUST00000000095.6
 Tbx2
T-box 2
chr10_-_127534540 0.717 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr2_+_49451486 0.638 ENSMUST00000092123.4
 Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr15_-_98004634 0.626 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr16_+_44173239 0.611 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr15_-_98004695 0.557 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr18_-_34931931 0.498 ENSMUST00000180351.1
 Etf1
eukaryotic translation termination factor 1
chr5_-_89883321 0.465 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr7_+_121707189 0.457 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr12_+_4592992 0.444 ENSMUST00000062580.7
 Itsn2
intersectin 2
chr19_-_58454435 0.441 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr12_+_76533540 0.440 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr8_-_105637403 0.435 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr13_-_21750505 0.432 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr16_+_20733104 0.425 ENSMUST00000115423.1
ENSMUST00000007171.6
 Chrd

chordin

chr2_+_121867083 0.418 ENSMUST00000089912.5
ENSMUST00000089915.3
 Casc4

cancer susceptibility candidate 4

chr4_-_91372028 0.417 ENSMUST00000107110.1
ENSMUST00000008633.8
ENSMUST00000107118.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr13_-_103920508 0.411 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr3_+_14533817 0.402 ENSMUST00000169079.1
ENSMUST00000091325.3
 Lrrcc1

leucine rich repeat and coiled-coil domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 1.0 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 0.8 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.2 0.7 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.1 0.7 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.2 0.6 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.1 0.6 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.1 0.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.5 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 0.5 GO:0015871 choline transport(GO:0015871)
0.1 0.5 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.5 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.5 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.5 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.3 0.8 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 0.8 GO:0001739 sex chromatin(GO:0001739)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.7 GO:0043596 nuclear replication fork(GO:0043596)
0.1 0.6 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.6 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.2 0.5 GO:0031251 PAN complex(GO:0031251)
0.1 0.5 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.4 GO:0000802 transverse filament(GO:0000802)
0.1 0.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.5 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.4 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)