Motif ID: Tcf7_Tcf7l2

Z-value: 0.880

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7mm10_v2_chr11_-_52282564_52282579-0.544.8e-02Click!
Tcf7l2mm10_v2_chr19_+_55895508_55895511-0.441.1e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102706356 1.358 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
 Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr2_+_96318014 1.261 ENSMUST00000135431.1
ENSMUST00000162807.2
 Lrrc4c

leucine rich repeat containing 4C

chrX_+_6415736 1.153 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chrX_+_101532734 0.980 ENSMUST00000118878.1
ENSMUST00000101341.2
ENSMUST00000149274.1
 Taf1


TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor


chr4_+_102430047 0.896 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr9_-_96719549 0.872 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38
chr6_-_136173492 0.814 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr1_+_132008285 0.808 ENSMUST00000146432.1
 Elk4
ELK4, member of ETS oncogene family
chr2_+_153031852 0.775 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr1_+_128244122 0.744 ENSMUST00000027592.3
 Ubxn4
UBX domain protein 4
chr17_+_21690766 0.724 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr7_-_28008416 0.713 ENSMUST00000180024.1
 Zfp850
zinc finger protein 850
chr18_+_10725651 0.711 ENSMUST00000165555.1
 Mib1
mindbomb homolog 1 (Drosophila)
chr5_-_63650264 0.685 ENSMUST00000067917.3
 Gm9954
predicted gene 9954
chr17_-_78684262 0.672 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr14_+_21750525 0.661 ENSMUST00000022292.3
 Samd8
sterile alpha motif domain containing 8
chr9_-_96719404 0.648 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38
chr3_+_55461758 0.621 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr4_-_15149755 0.614 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr12_-_41485751 0.599 ENSMUST00000043884.4
 Lrrn3
leucine rich repeat protein 3, neuronal

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0006275 regulation of DNA replication(GO:0006275)
0.2 1.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 1.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 0.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.9 GO:0001947 heart looping(GO:0001947)
0.1 0.8 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.8 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 0.5 GO:0048211 Golgi vesicle docking(GO:0048211)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.0 0.5 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.5 GO:0007032 endosome organization(GO:0007032)
0.1 0.4 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 0.4 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.6 GO:0072562 blood microparticle(GO:0072562)
0.0 1.4 GO:0030673 axolemma(GO:0030673)
0.1 1.1 GO:0016460 myosin II complex(GO:0016460)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.1 0.4 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.3 GO:0001533 cornified envelope(GO:0001533)
0.1 0.3 GO:0036449 microtubule minus-end(GO:0036449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.7 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.3 1.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.7 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.4 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.4 GO:0008536 Ran GTPase binding(GO:0008536)