Motif ID: Rest

Z-value: 1.348


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.401.6e-01Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_11037968 4.598 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr2_-_180104463 3.991 ENSMUST00000056480.3
 Hrh3
histamine receptor H3
chr5_+_137030275 3.368 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr19_+_42255704 3.134 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr7_+_122671401 2.594 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr12_+_119945957 2.476 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chr7_+_122671378 2.449 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr13_-_56895737 2.092 ENSMUST00000022023.6
ENSMUST00000109871.1
 Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr4_+_129136948 2.044 ENSMUST00000102600.3
 Fndc5
fibronectin type III domain containing 5
chr6_-_121473630 2.017 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr7_+_51621830 1.775 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr17_-_83631892 1.432 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr4_-_153482768 1.393 ENSMUST00000105646.2
 Ajap1
adherens junction associated protein 1
chr2_-_27142429 1.343 ENSMUST00000151224.2
 Fam163b
family with sequence similarity 163, member B
chr4_-_129121234 1.334 ENSMUST00000030572.3
 Hpca
hippocalcin
chr4_+_130055010 1.329 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr7_-_27396542 1.316 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr12_-_84698769 1.315 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr9_+_40873981 1.309 ENSMUST00000067375.3
 Bsx
brain specific homeobox
chr12_+_113140198 1.302 ENSMUST00000084882.4
 Crip2
cysteine rich protein 2
chr2_-_25319095 1.182 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr2_-_25319187 1.124 ENSMUST00000114312.1
 Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr15_-_76722161 1.079 ENSMUST00000049956.4
 Lrrc24
leucine rich repeat containing 24
chr4_+_15881255 1.063 ENSMUST00000029876.1
 Calb1
calbindin 1
chr7_+_19345135 0.972 ENSMUST00000160369.1
 Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
chr11_-_3774706 0.944 ENSMUST00000155197.1
 Osbp2
oxysterol binding protein 2
chr6_+_117168535 0.895 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
 Cxcl12


chemokine (C-X-C motif) ligand 12


chr7_-_79594924 0.880 ENSMUST00000172788.1
 Rhcg
Rhesus blood group-associated C glycoprotein
chr2_+_22622183 0.869 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr2_+_155775333 0.789 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr2_+_152143552 0.779 ENSMUST00000089112.5
 Tcf15
transcription factor 15
chr11_-_35798884 0.757 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr16_-_37384915 0.732 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chrX_-_20920911 0.643 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr17_-_23740301 0.576 ENSMUST00000024702.3
 Paqr4
progestin and adipoQ receptor family member IV
chr9_+_59578192 0.557 ENSMUST00000118549.1
ENSMUST00000034840.3
 Celf6

CUGBP, Elav-like family member 6

chr16_-_37384940 0.540 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr2_-_181314500 0.497 ENSMUST00000103045.3
 Stmn3
stathmin-like 3
chr10_+_90829409 0.491 ENSMUST00000182202.1
ENSMUST00000182966.1
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr17_-_25240112 0.485 ENSMUST00000038973.6
ENSMUST00000115154.4
 Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr11_+_74619594 0.484 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr18_-_31447383 0.482 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr7_+_27653906 0.478 ENSMUST00000008088.7
 Ttc9b
tetratricopeptide repeat domain 9B
chr6_+_8948608 0.469 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr17_+_25240166 0.445 ENSMUST00000063574.6
 Tsr3
TSR3 20S rRNA accumulation
chr1_+_34579693 0.429 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr16_-_23890805 0.370 ENSMUST00000004480.3
 Sst
somatostatin
chr9_+_122117338 0.339 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
 Snrk


SNF related kinase


chr11_-_117873433 0.301 ENSMUST00000033230.7
 Tha1
threonine aldolase 1
chr7_-_81493725 0.293 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr13_-_105054895 0.281 ENSMUST00000063551.5
 Rgs7bp
regulator of G-protein signalling 7 binding protein
chr17_+_28575718 0.275 ENSMUST00000080780.6
 Lhfpl5
lipoma HMGIC fusion partner-like 5
chr7_+_49910112 0.269 ENSMUST00000056442.5
 Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr15_-_75747922 0.258 ENSMUST00000062002.4
 Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr10_+_90829538 0.245 ENSMUST00000179694.2
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr9_-_57467985 0.225 ENSMUST00000046587.6
 Scamp5
secretory carrier membrane protein 5
chr19_+_5038826 0.223 ENSMUST00000053705.6
 B3gnt1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chrX_+_7638674 0.196 ENSMUST00000128890.1
 Syp
synaptophysin
chr11_+_69914179 0.188 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chr8_+_18846251 0.187 ENSMUST00000149565.1
ENSMUST00000033847.4
 Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr9_+_122117375 0.184 ENSMUST00000118886.1
 Snrk
SNF related kinase
chr6_+_113282302 0.179 ENSMUST00000041203.5
 Cpne9
copine family member IX
chr3_-_80802789 0.169 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr2_-_92401237 0.167 ENSMUST00000050312.2
 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr7_-_81493883 0.162 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr17_-_72603709 0.152 ENSMUST00000086639.4
 Alk
anaplastic lymphoma kinase
chr19_+_22139028 0.147 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr1_+_81077204 0.125 ENSMUST00000123720.1
 Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr13_-_54749627 0.123 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr19_-_8929323 0.107 ENSMUST00000096242.3
 Rom1
rod outer segment membrane protein 1
chr5_+_38260372 0.089 ENSMUST00000119047.1
 Tmem128
transmembrane protein 128
chr8_+_69088646 0.070 ENSMUST00000006435.7
 Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr11_+_102393403 0.044 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
 Rundc3a



RUN domain containing 3A



chr13_-_54749849 0.029 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr1_+_81077274 0.026 ENSMUST00000068275.5
ENSMUST00000113494.2
 Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr1_-_162548484 0.022 ENSMUST00000028017.9
 Mettl13
methyltransferase like 13
chr17_-_91092715 0.013 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr12_+_102554966 0.008 ENSMUST00000021610.5
 Chga
chromogranin A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.8 2.3 GO:1900673 olefin metabolic process(GO:1900673)
0.4 1.3 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 1.0 GO:0006295 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) positive regulation of t-circle formation(GO:1904431)
0.3 4.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 0.9 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.3 2.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 3.4 GO:0043084 penile erection(GO:0043084)
0.2 0.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 1.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 0.9 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 5.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 0.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 0.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 1.3 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.3 GO:0006566 threonine metabolic process(GO:0006566)
0.1 2.1 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0001504 neurotransmitter uptake(GO:0001504)
0.1 0.8 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.1 0.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.3 GO:0051894 integrin activation(GO:0033622) positive regulation of focal adhesion assembly(GO:0051894)
0.1 1.1 GO:0007614 short-term memory(GO:0007614)
0.0 0.3 GO:0036233 glycine import(GO:0036233)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.6 GO:0071625 vocalization behavior(GO:0071625)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.2 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0044307 dendritic branch(GO:0044307)
0.3 1.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.2 1.3 GO:0008091 spectrin(GO:0008091)
0.1 1.3 GO:0044327 dendritic spine head(GO:0044327)
0.1 5.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 2.9 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 3.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 2.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 4.0 GO:0043209 myelin sheath(GO:0043209)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 2.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 2.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 3.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 5.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.3 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 1.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.6 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0015375 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.2 GO:0005496 steroid binding(GO:0005496)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0045296 cadherin binding(GO:0045296)
0.0 0.0 GO:0030249 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.0 0.8 GO:0042054 histone methyltransferase activity(GO:0042054)