Motif ID: Otx1

Z-value: 0.345


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_22001631-0.451.1e-01Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_60963192 0.956 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr13_-_60897439 0.841 ENSMUST00000171347.1
ENSMUST00000021884.8
 Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr15_-_74734313 0.704 ENSMUST00000023260.3
 Lypd2
Ly6/Plaur domain containing 2
chrM_+_11734 0.543 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_-_165708088 0.477 ENSMUST00000040357.8
ENSMUST00000097474.3
 Rcsd1

RCSD domain containing 1

chr12_-_46818749 0.431 ENSMUST00000021438.6
 Nova1
neuro-oncological ventral antigen 1
chr9_+_68653761 0.417 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chr10_+_123264076 0.408 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr7_-_79848191 0.405 ENSMUST00000107392.1
 Anpep
alanyl (membrane) aminopeptidase
chr12_+_103434211 0.393 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr10_+_127642975 0.352 ENSMUST00000092074.5
ENSMUST00000120279.1
 Stat6

signal transducer and activator of transcription 6

chr18_+_57468478 0.334 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr2_+_175275125 0.331 ENSMUST00000109051.1
 Gm14440
predicted gene 14440
chr7_-_83550258 0.325 ENSMUST00000177929.1
 Gm10610
predicted gene 10610
chr9_+_108479849 0.308 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr11_-_116694802 0.303 ENSMUST00000079545.5
 St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr5_-_5749317 0.291 ENSMUST00000015796.2
 Steap1
six transmembrane epithelial antigen of the prostate 1
chr15_-_79285502 0.269 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr11_+_94936224 0.264 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr5_+_109923400 0.223 ENSMUST00000112544.1
 Gm15446
predicted gene 15446
chr13_-_60936550 0.213 ENSMUST00000021880.9
 Ctla2a
cytotoxic T lymphocyte-associated protein 2 alpha
chr13_+_21735055 0.209 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr2_+_177897096 0.208 ENSMUST00000108935.1
 Gm14327
predicted gene 14327
chr14_-_122913751 0.206 ENSMUST00000160401.1
 Ggact
gamma-glutamylamine cyclotransferase
chr19_+_5689131 0.190 ENSMUST00000004156.8
 Map3k11
mitogen-activated protein kinase kinase kinase 11
chrM_+_10167 0.187 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr10_+_29313164 0.185 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr13_-_92030897 0.182 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr5_-_37336870 0.181 ENSMUST00000031005.4
 Evc
Ellis van Creveld gene syndrome
chr10_-_7473361 0.178 ENSMUST00000169796.2
ENSMUST00000177585.1
 Ulbp1

UL16 binding protein 1

chr11_+_78346666 0.177 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr4_-_42661893 0.168 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr11_+_103116228 0.167 ENSMUST00000053063.5
 Hexim1
hexamethylene bis-acetamide inducible 1
chr2_-_156180135 0.141 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr1_-_24612700 0.134 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr19_-_42779936 0.131 ENSMUST00000069298.6
ENSMUST00000160455.1
ENSMUST00000162004.1
 Hps1


Hermansky-Pudlak syndrome 1 homolog (human)


chr18_+_80206887 0.129 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr2_+_178023284 0.126 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chr13_-_55321928 0.120 ENSMUST00000035242.7
 Rab24
RAB24, member RAS oncogene family
chr4_-_41517326 0.114 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr6_+_48589560 0.108 ENSMUST00000181661.1
 Gm5111
predicted gene 5111
chr13_+_93771656 0.105 ENSMUST00000091403.4
 Arsb
arylsulfatase B
chr7_-_100662315 0.095 ENSMUST00000151123.1
ENSMUST00000107047.2
 Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr14_-_87141206 0.089 ENSMUST00000022599.7
 Diap3
diaphanous homolog 3 (Drosophila)
chr11_+_3963970 0.088 ENSMUST00000020705.4
ENSMUST00000109985.1
 Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr6_-_29507946 0.085 ENSMUST00000101614.3
ENSMUST00000078112.6
 Kcp

kielin/chordin-like protein

chr19_+_5024006 0.084 ENSMUST00000025826.5
 Slc29a2
solute carrier family 29 (nucleoside transporters), member 2
chr4_+_58943575 0.079 ENSMUST00000107554.1
 Zkscan16
zinc finger with KRAB and SCAN domains 16
chr5_-_69590783 0.074 ENSMUST00000173927.1
 Gnpda2
glucosamine-6-phosphate deaminase 2
chr14_-_87141114 0.072 ENSMUST00000168889.1
 Diap3
diaphanous homolog 3 (Drosophila)
chr10_-_93889758 0.072 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
 Metap2



methionine aminopeptidase 2



chr8_-_46151705 0.065 ENSMUST00000041582.8
 Snx25
sorting nexin 25
chr7_-_80403315 0.064 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr11_+_115564434 0.063 ENSMUST00000021085.4
 Nup85
nucleoporin 85
chr5_+_15516489 0.062 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr3_+_18054258 0.062 ENSMUST00000026120.6
 Bhlhe22
basic helix-loop-helix family, member e22
chr3_-_146682410 0.060 ENSMUST00000124931.1
ENSMUST00000147113.1
 Samd13

sterile alpha motif domain containing 13

chr3_+_66985647 0.056 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chrX_-_95956890 0.053 ENSMUST00000079987.6
ENSMUST00000113864.2
 Las1l

LAS1-like (S. cerevisiae)

chr4_-_132422484 0.051 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chr2_+_154656959 0.046 ENSMUST00000044277.9
 Chmp4b
charged multivesicular body protein 4B
chr10_+_80054029 0.041 ENSMUST00000097227.3
 Gpx4
glutathione peroxidase 4
chr3_+_66985947 0.040 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr14_+_29968308 0.037 ENSMUST00000112268.1
 Selk
selenoprotein K
chr7_-_100662414 0.036 ENSMUST00000079176.6
 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr10_+_3973086 0.032 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr16_+_91647859 0.031 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr15_+_80133114 0.030 ENSMUST00000023050.7
 Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr19_-_10869757 0.029 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr17_+_35861343 0.028 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr1_-_118311132 0.027 ENSMUST00000027623.7
 Tsn
translin
chr19_+_41933464 0.025 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr11_-_116274102 0.023 ENSMUST00000106425.3
 Srp68
signal recognition particle 68
chr7_-_104950441 0.012 ENSMUST00000179862.1
 Gm5900
predicted pseudogene 5900
chr7_-_132154717 0.010 ENSMUST00000033149.4
 Cpxm2
carboxypeptidase X 2 (M14 family)
chr10_-_88605017 0.008 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr2_-_26933781 0.003 ENSMUST00000154651.1
ENSMUST00000015011.3
 Surf4

surfeit gene 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002295 T-helper cell lineage commitment(GO:0002295) interleukin-4-mediated signaling pathway(GO:0035771)
0.1 0.3 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.1 0.4 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 0.3 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.3 GO:0097503 sialylation(GO:0097503)
0.1 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.4 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.2 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.0 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.3 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.3 GO:0043256 laminin complex(GO:0043256)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.3 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.2 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0008932 lytic endotransglycosylase activity(GO:0008932)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.0 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)