Motif ID: Six3_Six1_Six2
Z-value: 1.492
Transcription factors associated with Six3_Six1_Six2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Six1 | ENSMUSG00000051367.8 | Six1 |
Six2 | ENSMUSG00000024134.10 | Six2 |
Six3 | ENSMUSG00000038805.9 | Six3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Six3 | mm10_v2_chr17_+_85621017_85621031 | 0.90 | 1.1e-05 | Click! |
Six2 | mm10_v2_chr17_-_85688252_85688275 | 0.39 | 1.7e-01 | Click! |
Six1 | mm10_v2_chr12_-_73047179_73047179 | 0.34 | 2.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 9.7 | GO:0051923 | sulfation(GO:0051923) |
0.8 | 2.4 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) |
0.8 | 2.4 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
0.7 | 3.3 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
0.5 | 2.1 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.4 | 1.7 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
0.4 | 2.0 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.3 | 2.0 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
0.3 | 1.1 | GO:0048539 | bone marrow development(GO:0048539) |
0.2 | 2.2 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.2 | 1.3 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
0.2 | 0.5 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.2 | 6.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.1 | 0.4 | GO:0006097 | glyoxylate cycle(GO:0006097) |
0.1 | 0.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 1.3 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.1 | 0.7 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
0.1 | 1.1 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.1 | 1.0 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.1 | 0.3 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.1 | 0.5 | GO:0015670 | carbon dioxide transport(GO:0015670) |
0.0 | 1.6 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
0.0 | 0.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.0 | 0.1 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
0.0 | 1.5 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
0.0 | 0.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.0 | 0.1 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
0.0 | 0.8 | GO:0001706 | endoderm formation(GO:0001706) |
0.0 | 0.5 | GO:0008206 | bile acid metabolic process(GO:0008206) |
0.0 | 1.1 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
0.0 | 0.0 | GO:0021698 | cerebellar cortex structural organization(GO:0021698) |
0.0 | 0.9 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
0.0 | 0.0 | GO:0048496 | maintenance of organ identity(GO:0048496) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
0.4 | 1.5 | GO:0045098 | type III intermediate filament(GO:0045098) |
0.3 | 0.8 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.3 | 2.3 | GO:0061574 | ASAP complex(GO:0061574) |
0.2 | 2.4 | GO:0044327 | dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327) |
0.2 | 2.0 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
0.2 | 2.0 | GO:0005688 | U6 snRNP(GO:0005688) |
0.1 | 2.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.1 | 5.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 1.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 0.4 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 2.7 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 2.4 | GO:0031513 | nonmotile primary cilium(GO:0031513) |
0.0 | 6.0 | GO:0005874 | microtubule(GO:0005874) |
0.0 | 0.0 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 2.4 | GO:0044306 | neuron projection terminus(GO:0044306) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.2 | 9.7 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
0.7 | 2.0 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
0.4 | 2.4 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.4 | 2.0 | GO:0030621 | U4 snRNA binding(GO:0030621) |
0.4 | 2.1 | GO:0019841 | retinol binding(GO:0019841) |
0.2 | 0.5 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 0.4 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
0.1 | 0.5 | GO:0008410 | CoA-transferase activity(GO:0008410) |
0.1 | 0.8 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.1 | 0.3 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
0.1 | 1.5 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.1 | 1.5 | GO:0005003 | ephrin receptor activity(GO:0005003) |
0.1 | 1.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
0.1 | 2.0 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.0 | 2.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.0 | 0.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.0 | 2.2 | GO:0030331 | estrogen receptor binding(GO:0030331) |
0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.9 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.9 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
0.0 | 4.9 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
0.0 | 3.3 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 1.1 | GO:0051087 | chaperone binding(GO:0051087) |