Motif ID: Six3_Six1_Six2

Z-value: 1.492

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85621017_856210310.901.1e-05Click!
Six2mm10_v2_chr17_-_85688252_856882750.391.7e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.342.4e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_94083490 9.056 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chrX_+_169685191 6.779 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr7_-_126676357 5.029 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr18_+_56432116 4.973 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr7_-_126676428 4.699 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chrX_-_142966709 3.837 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_-_75894474 3.684 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr1_+_139454747 3.317 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr8_+_57455898 2.681 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr14_+_123659971 2.476 ENSMUST00000049681.7
 Itgbl1
integrin, beta-like 1
chr5_+_139423151 2.421 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr9_+_72958785 2.240 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr15_-_82244716 2.183 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr9_+_98422961 2.111 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr6_+_48537560 1.968 ENSMUST00000040361.5
 Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr5_+_140607334 1.957 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr10_+_24595623 1.719 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr7_+_30231884 1.675 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr3_-_85722474 1.672 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr16_-_60605226 1.527 ENSMUST00000068860.6
 Epha6
Eph receptor A6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.7 GO:0051923 sulfation(GO:0051923)
0.2 6.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.7 3.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.8 2.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.8 2.4 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 2.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.5 2.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 2.0 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.0 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.4 1.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 1.6 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 1.5 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.2 1.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 1.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 1.1 GO:0048539 bone marrow development(GO:0048539)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 1.0 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.9 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.8 GO:0001706 endoderm formation(GO:0001706)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0005874 microtubule(GO:0005874)
0.1 5.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.7 3.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.2 2.4 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.1 2.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 2.4 GO:0031513 nonmotile primary cilium(GO:0031513)
0.0 2.4 GO:0044306 neuron projection terminus(GO:0044306)
0.3 2.3 GO:0061574 ASAP complex(GO:0061574)
0.2 2.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.0 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.4 1.5 GO:0045098 type III intermediate filament(GO:0045098)
0.3 0.8 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:0097543 ciliary inversin compartment(GO:0097543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 9.7 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 4.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.3 GO:0005516 calmodulin binding(GO:0005516)
0.4 2.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 2.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.4 2.1 GO:0019841 retinol binding(GO:0019841)
0.7 2.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.0 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 2.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.5 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.5 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0051087 chaperone binding(GO:0051087)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.1 0.8 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.2 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.5 GO:0008410 CoA-transferase activity(GO:0008410)