Motif ID: Six3_Six1_Six2

Z-value: 1.492

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85621017_856210310.901.1e-05Click!
Six2mm10_v2_chr17_-_85688252_856882750.391.7e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.342.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_94083490 9.056 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chrX_+_169685191 6.779 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr7_-_126676357 5.029 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr18_+_56432116 4.973 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr7_-_126676428 4.699 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chrX_-_142966709 3.837 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_-_75894474 3.684 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr1_+_139454747 3.317 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr8_+_57455898 2.681 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr14_+_123659971 2.476 ENSMUST00000049681.7
Itgbl1
integrin, beta-like 1
chr5_+_139423151 2.421 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr9_+_72958785 2.240 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr15_-_82244716 2.183 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr9_+_98422961 2.111 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr6_+_48537560 1.968 ENSMUST00000040361.5
Atp6v0e2
ATPase, H+ transporting, lysosomal V0 subunit E2
chr5_+_140607334 1.957 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr10_+_24595623 1.719 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr7_+_30231884 1.675 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr3_-_85722474 1.672 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr16_-_60605226 1.527 ENSMUST00000068860.6
Epha6
Eph receptor A6
chr13_+_43785107 1.298 ENSMUST00000015540.2
Cd83
CD83 antigen
chr4_-_32950813 1.291 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr14_+_57798182 1.288 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr15_+_98571004 1.264 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr9_+_65141154 1.220 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr17_+_35241838 1.097 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr5_+_21543525 1.081 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr11_-_69695521 1.070 ENSMUST00000181261.1
Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr3_-_37724321 1.063 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr8_-_4275886 1.061 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr14_+_57798156 0.977 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr6_+_38534823 0.951 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr17_-_56716788 0.910 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr17_+_35241746 0.855 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr2_+_127336152 0.819 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr7_-_141168671 0.765 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr3_+_88207308 0.763 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr19_-_23075853 0.723 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr5_-_106926245 0.707 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr7_+_30232310 0.682 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr17_-_56717681 0.543 ENSMUST00000164907.1
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr2_-_13271419 0.542 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr3_+_130068390 0.537 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr4_+_11758147 0.529 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr17_-_53539411 0.504 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr11_-_101987004 0.501 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr12_+_30584429 0.488 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr17_+_40811089 0.487 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr13_+_104229366 0.486 ENSMUST00000022227.6
Cenpk
centromere protein K
chr2_-_13271268 0.485 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr9_+_119341487 0.455 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr3_+_94398517 0.431 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr7_-_80115294 0.429 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr15_-_76206309 0.367 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr15_+_82252397 0.359 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr2_+_131491764 0.311 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr2_-_119029359 0.194 ENSMUST00000110833.1
Ccdc32
coiled-coil domain containing 32
chr10_+_100488289 0.189 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr12_+_84773262 0.184 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr8_+_69832633 0.178 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr9_-_121839460 0.171 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr14_+_58893465 0.149 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr8_-_22653406 0.137 ENSMUST00000033938.5
Polb
polymerase (DNA directed), beta
chr7_-_101903783 0.129 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr2_-_119029392 0.106 ENSMUST00000036470.7
ENSMUST00000110834.1
Ccdc32

coiled-coil domain containing 32

chr17_+_56717759 0.082 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr5_-_62765618 0.056 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_136467958 0.044 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr9_+_104002546 0.030 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr6_-_115675871 0.005 ENSMUST00000112949.1
Raf1
v-raf-leukemia viral oncogene 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.7 GO:0051923 sulfation(GO:0051923)
0.8 2.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.8 2.4 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.7 3.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.5 2.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.4 1.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.4 2.0 GO:0007386 compartment pattern specification(GO:0007386)
0.3 2.0 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 1.1 GO:0048539 bone marrow development(GO:0048539)
0.2 2.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 1.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.2 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 6.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.0 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.3 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 1.6 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 1.5 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.8 GO:0001706 endoderm formation(GO:0001706)
0.0 0.5 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 1.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.0 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.9 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0036449 microtubule minus-end(GO:0036449)
0.4 1.5 GO:0045098 type III intermediate filament(GO:0045098)
0.3 0.8 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 2.3 GO:0061574 ASAP complex(GO:0061574)
0.2 2.4 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.2 2.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.0 GO:0005688 U6 snRNP(GO:0005688)
0.1 2.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 5.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.0 2.4 GO:0031513 nonmotile primary cilium(GO:0031513)
0.0 6.0 GO:0005874 microtubule(GO:0005874)
0.0 0.0 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 2.4 GO:0044306 neuron projection terminus(GO:0044306)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.7 2.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 2.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.4 2.0 GO:0030621 U4 snRNA binding(GO:0030621)
0.4 2.1 GO:0019841 retinol binding(GO:0019841)
0.2 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.5 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 0.8 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 1.5 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.5 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 2.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 2.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.9 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 4.9 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 3.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.1 GO:0051087 chaperone binding(GO:0051087)