Motif ID: Cux1

Z-value: 1.314


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136567242_1365672870.876.4e-05Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 4.410 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr2_+_71529085 4.285 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chrY_+_90755657 3.699 ENSMUST00000167967.2
 Gm21857
predicted gene, 21857
chr10_-_117282262 3.009 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr5_-_70842617 2.332 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr13_-_92030897 2.270 ENSMUST00000149630.1
 Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr5_+_63649335 2.218 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr5_-_122050102 2.215 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr7_-_19698383 2.155 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr11_+_78499087 2.063 ENSMUST00000017488.4
 Vtn
vitronectin
chr2_-_164171113 2.026 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chrX_+_169685191 1.947 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr3_-_53657339 1.941 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr7_-_19698206 1.852 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr5_-_43981757 1.751 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr2_+_22622183 1.676 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr7_-_93081027 1.666 ENSMUST00000098303.1
 Gm9934
predicted gene 9934
chr1_+_171840607 1.634 ENSMUST00000136479.1
ENSMUST00000042302.6
 Cd84

CD84 antigen

chrX_+_142228177 1.546 ENSMUST00000112914.1
 Nxt2
nuclear transport factor 2-like export factor 2
chr9_-_120068263 1.537 ENSMUST00000064165.3
ENSMUST00000177637.1
 Cx3cr1

chemokine (C-X3-C) receptor 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.3 4.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 3.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 3.0 GO:0019835 cytolysis(GO:0019835)
0.0 2.9 GO:0051028 mRNA transport(GO:0051028)
0.2 2.3 GO:0060346 bone trabecula formation(GO:0060346)
0.1 2.3 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 2.2 GO:0007614 short-term memory(GO:0007614)
0.2 2.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.6 1.9 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.2 1.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.5 1.6 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.1 1.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 1.5 GO:1900272 negative regulation of long-term synaptic potentiation(GO:1900272)
0.4 1.4 GO:0006538 glutamate catabolic process(GO:0006538)
0.3 1.4 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.3 1.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 1.3 GO:0070295 renal water absorption(GO:0070295)
0.1 1.3 GO:0015721 bile acid and bile salt transport(GO:0015721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.3 4.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 3.1 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.4 GO:0005604 basement membrane(GO:0005604)
0.0 2.0 GO:0070469 respiratory chain(GO:0070469)
0.0 1.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.0 1.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 1.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3 0.9 GO:0034679 integrin alpha9-beta1 complex(GO:0034679)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.6 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
1.3 4.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 3.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 1.9 GO:0043237 laminin-1 binding(GO:0043237)
0.0 1.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 1.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 1.5 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 1.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.5 1.4 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
0.2 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.2 1.3 GO:0015288 porin activity(GO:0015288)
0.0 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 1.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.3 1.1 GO:0004337 geranyltranstransferase activity(GO:0004337)
0.2 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)