Motif ID: E2f2_E2f5

Z-value: 1.484

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.761.8e-03Click!
E2f5mm10_v2_chr3_+_14578609_145786870.742.3e-03Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_58135047 2.915 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr4_+_126556935 2.857 ENSMUST00000048391.8
 Clspn
claspin
chr2_+_72476159 2.618 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr4_+_136172367 2.613 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr10_-_69352886 2.560 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr14_+_51984857 2.338 ENSMUST00000100639.4
ENSMUST00000182909.1
ENSMUST00000182760.1
ENSMUST00000182061.1
ENSMUST00000182193.1
 Arhgef40




Rho guanine nucleotide exchange factor (GEF) 40




chr9_+_122951051 2.267 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr14_+_51984826 2.145 ENSMUST00000093813.5
 Arhgef40
Rho guanine nucleotide exchange factor (GEF) 40
chr4_+_115000156 2.080 ENSMUST00000030490.6
 Stil
Scl/Tal1 interrupting locus
chr15_-_55090422 1.984 ENSMUST00000110231.1
ENSMUST00000023059.6
 Dscc1

defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

chr9_+_13827708 1.935 ENSMUST00000059579.5
 Fam76b
family with sequence similarity 76, member B
chr7_+_19359740 1.907 ENSMUST00000140836.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr2_+_72476225 1.906 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr5_-_45857473 1.893 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr12_+_11265867 1.811 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr15_-_8444449 1.776 ENSMUST00000052965.6
 Nipbl
Nipped-B homolog (Drosophila)
chr9_-_13827029 1.747 ENSMUST00000148086.1
ENSMUST00000034398.5
 Cep57

centrosomal protein 57

chr1_-_128359610 1.709 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr2_-_157204483 1.695 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr19_-_8723356 1.633 ENSMUST00000170157.1
 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 4.8 GO:0006270 DNA replication initiation(GO:0006270)
0.0 4.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.3 4.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 3.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 3.5 GO:0033504 floor plate development(GO:0033504)
0.3 3.4 GO:1902969 mitotic DNA replication(GO:1902969)
0.3 3.0 GO:0090166 Golgi disassembly(GO:0090166)
0.3 3.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.3 2.9 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 2.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.2 2.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 2.1 GO:0019985 translesion synthesis(GO:0019985)
0.4 2.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 1.9 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.4 1.8 GO:0061010 gall bladder development(GO:0061010)
0.4 1.7 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.1 1.7 GO:0034453 microtubule anchoring(GO:0034453)
0.3 1.6 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 1.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.9 GO:0005814 centriole(GO:0005814)
0.3 4.8 GO:0042555 MCM complex(GO:0042555)
0.0 3.6 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.8 GO:0005871 kinesin complex(GO:0005871)
0.0 2.6 GO:0005876 spindle microtubule(GO:0005876)
0.5 2.5 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 2.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 2.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 2.1 GO:0045171 intercellular bridge(GO:0045171)
0.2 2.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 1.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.6 1.8 GO:0000811 GINS complex(GO:0000811)
0.1 1.8 GO:0000786 nucleosome(GO:0000786)
0.6 1.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 1.4 GO:0000798 nuclear cohesin complex(GO:0000798) nuclear meiotic cohesin complex(GO:0034991)
0.1 1.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.2 1.2 GO:0000800 lateral element(GO:0000800)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0001047 core promoter binding(GO:0001047)
0.0 4.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 4.1 GO:0003678 DNA helicase activity(GO:0003678)
0.6 3.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 3.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.7 2.8 GO:0036033 mediator complex binding(GO:0036033)
0.0 2.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.8 GO:0042393 histone binding(GO:0042393)
0.1 2.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.6 1.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 1.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 1.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 1.7 GO:0003896 DNA primase activity(GO:0003896)
0.2 1.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.6 GO:1990226 histone methyltransferase binding(GO:1990226)