Motif ID: Tfap2b

Z-value: 0.677


Transcription factors associated with Tfap2b:

Gene SymbolEntrez IDGene Name
Tfap2b ENSMUSG00000025927.7 Tfap2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2bmm10_v2_chr1_+_19208914_19208967-0.479.3e-02Click!


Activity profile for motif Tfap2b.

activity profile for motif Tfap2b


Sorted Z-values histogram for motif Tfap2b

Sorted Z-values for motif Tfap2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_172043466 1.296 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr15_-_11905609 0.696 ENSMUST00000066529.3
 Npr3
natriuretic peptide receptor 3
chr1_-_56978534 0.571 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_123183456 0.567 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr4_+_123183722 0.504 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr2_+_158667119 0.501 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_+_158666690 0.500 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_-_11502090 0.496 ENSMUST00000179584.1
ENSMUST00000170196.2
ENSMUST00000171188.2
ENSMUST00000114845.3
ENSMUST00000114844.1
ENSMUST00000100411.2
 Pfkfb3





6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3





chr17_-_83631892 0.490 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr7_-_127448993 0.489 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr11_+_77348272 0.468 ENSMUST00000181283.1
 Ssh2
slingshot homolog 2 (Drosophila)
chr5_+_138194277 0.429 ENSMUST00000057773.4
 Mblac1
metallo-beta-lactamase domain containing 1
chr12_+_108410625 0.426 ENSMUST00000109857.1
 Eml1
echinoderm microtubule associated protein like 1
chr15_-_38300693 0.407 ENSMUST00000074043.5
 Klf10
Kruppel-like factor 10
chr2_-_11502067 0.389 ENSMUST00000028114.6
ENSMUST00000049849.6
 Pfkfb3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

chr7_-_98162318 0.385 ENSMUST00000107112.1
 Capn5
calpain 5
chr9_-_110742577 0.379 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr11_+_35121126 0.379 ENSMUST00000069837.3
 Slit3
slit homolog 3 (Drosophila)
chr12_+_108410542 0.373 ENSMUST00000054955.7
 Eml1
echinoderm microtubule associated protein like 1
chr1_-_56972437 0.371 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0002076 osteoblast development(GO:0002076)
0.1 1.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 1.0 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.7 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.6 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 0.4 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.4 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 0.4 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 0.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.3 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.3 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0001553 luteinization(GO:0001553)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.3 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.2 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0097255 R2TP complex(GO:0097255)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0030286 dynein complex(GO:0030286)
0.1 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 1.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.4 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.3 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)