Motif ID: Nfatc4

Z-value: 0.625


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.621.8e-02Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_91400990 1.170 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr2_+_125136692 1.036 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr3_+_84925476 0.996 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr16_+_43364145 0.882 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr10_+_21993890 0.868 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr1_-_56978534 0.847 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_3270767 0.827 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr14_-_25927672 0.824 ENSMUST00000185006.1
 Tmem254a
transmembrane protein 254a
chr2_+_116067213 0.815 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr14_-_25927250 0.801 ENSMUST00000100811.5
 Tmem254a
transmembrane protein 254a
chr14_-_26067355 0.787 ENSMUST00000100819.5
 Tmem254c
transmembrane protein 254c
chr17_-_49564262 0.748 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr18_-_15063560 0.667 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr18_+_73863672 0.600 ENSMUST00000134847.1
 Mro
maestro
chr5_+_145114280 0.585 ENSMUST00000141602.1
 Arpc1b
actin related protein 2/3 complex, subunit 1B
chr3_-_152193803 0.572 ENSMUST00000050073.6
 Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_-_144177259 0.545 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr2_-_116067391 0.507 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr1_-_56969864 0.471 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr16_-_59555752 0.463 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr13_+_83504032 0.428 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_130107556 0.423 ENSMUST00000030563.5
 Pef1
penta-EF hand domain containing 1
chr15_-_79932516 0.403 ENSMUST00000177044.1
ENSMUST00000109615.1
ENSMUST00000089293.4
ENSMUST00000109616.2
 Cbx7



chromobox 7



chr4_+_48049080 0.378 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr12_-_86079019 0.316 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr19_-_24477356 0.244 ENSMUST00000099556.1
 Fam122a
family with sequence similarity 122, member A
chr7_-_84679346 0.229 ENSMUST00000069537.2
ENSMUST00000178385.1
 Zfand6

zinc finger, AN1-type domain 6

chrX_-_23365044 0.223 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr2_-_169405435 0.215 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr19_-_8839181 0.214 ENSMUST00000096259.4
 Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr8_-_67818218 0.203 ENSMUST00000059374.4
 Psd3
pleckstrin and Sec7 domain containing 3
chr2_-_73453918 0.198 ENSMUST00000102679.1
 Wipf1
WAS/WASL interacting protein family, member 1
chr4_-_148159838 0.195 ENSMUST00000151127.1
ENSMUST00000105705.2
 Fbxo44

F-box protein 44

chr11_+_75468040 0.167 ENSMUST00000043598.7
ENSMUST00000108435.1
 Tlcd2

TLC domain containing 2

chr2_+_72285637 0.161 ENSMUST00000090824.5
ENSMUST00000135469.1
 Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr3_-_116662643 0.143 ENSMUST00000029570.5
 Hiat1
hippocampus abundant gene transcript 1
chr7_-_4778141 0.143 ENSMUST00000094892.5
 Il11
interleukin 11
chr2_-_73660351 0.134 ENSMUST00000154258.1
 Chn1
chimerin (chimaerin) 1
chr10_+_4611971 0.128 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr9_-_35176039 0.123 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger

chr3_-_37125943 0.123 ENSMUST00000029275.5
 Il2
interleukin 2
chr1_-_64121456 0.118 ENSMUST00000142009.1
ENSMUST00000114086.1
 Klf7

Kruppel-like factor 7 (ubiquitous)

chr19_+_8839298 0.115 ENSMUST00000160556.1
 Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr9_-_13446753 0.109 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr1_-_64121389 0.106 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr4_-_3938354 0.103 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr19_+_8850785 0.103 ENSMUST00000096257.2
 Lrrn4cl
LRRN4 C-terminal like
chr8_-_67818284 0.101 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr17_-_70849644 0.098 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr15_-_79062866 0.085 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr5_+_117363513 0.070 ENSMUST00000111959.1
 Wsb2
WD repeat and SOCS box-containing 2
chr4_+_133176336 0.063 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr11_+_88718442 0.062 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr3_+_88214474 0.059 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chr11_-_35980473 0.046 ENSMUST00000018993.6
 Wwc1
WW, C2 and coiled-coil domain containing 1
chr3_+_94837533 0.037 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr19_-_4943049 0.023 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr6_+_134981998 0.020 ENSMUST00000167323.1
 Apold1
apolipoprotein L domain containing 1
chr6_-_23248264 0.017 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_7671341 0.016 ENSMUST00000033486.5
 Plp2
proteolipid protein 2
chr8_-_64205970 0.015 ENSMUST00000066166.4
 Tll1
tolloid-like
chr3_-_86548268 0.013 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.4 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 0.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.3 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 1.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 1.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.8 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)