Motif ID: Foxo3

Z-value: 0.613


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.631.5e-02Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_101785252 2.159 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr11_-_100354040 1.795 ENSMUST00000173630.1
Hap1
huntingtin-associated protein 1
chr14_-_51913393 1.535 ENSMUST00000004673.7
ENSMUST00000111632.3
Ndrg2

N-myc downstream regulated gene 2

chr10_+_112271123 1.512 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr16_+_93683184 1.508 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr3_+_5218546 1.458 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr10_-_49783259 1.335 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr1_-_140183404 1.147 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr4_+_105157339 1.057 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr13_-_23622502 1.043 ENSMUST00000062045.2
Hist1h1e
histone cluster 1, H1e
chr2_-_51972990 1.038 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr7_-_90129339 0.979 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr11_-_94242701 0.971 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr2_-_51973219 0.944 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr3_+_5218516 0.939 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr11_-_68386821 0.898 ENSMUST00000021284.3
Ntn1
netrin 1
chr7_-_109616548 0.883 ENSMUST00000077909.1
ENSMUST00000084738.3
St5

suppression of tumorigenicity 5

chr4_+_94739276 0.820 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr15_+_79347534 0.814 ENSMUST00000096350.3
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr1_-_140183283 0.811 ENSMUST00000111977.1
Cfh
complement component factor h
chr17_+_43389436 0.781 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr2_+_4718145 0.759 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr3_+_84925476 0.739 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr10_-_93310963 0.735 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr15_+_79348061 0.710 ENSMUST00000163691.1
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr10_-_53647080 0.697 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr2_+_138278481 0.695 ENSMUST00000075410.4
Btbd3
BTB (POZ) domain containing 3
chr16_-_43979050 0.688 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr3_+_53488677 0.672 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr14_-_57133585 0.630 ENSMUST00000039380.8
Gjb6
gap junction protein, beta 6
chr10_-_93311073 0.609 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr3_-_145649970 0.587 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr15_-_89379246 0.585 ENSMUST00000049968.7
Odf3b
outer dense fiber of sperm tails 3B
chr7_+_141476374 0.562 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr5_-_123140135 0.543 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr8_-_84773381 0.522 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr7_+_82175156 0.507 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr18_+_50051702 0.493 ENSMUST00000134348.1
ENSMUST00000153873.2
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr3_+_5218589 0.445 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr7_+_113765998 0.425 ENSMUST00000046687.9
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr5_-_151190154 0.415 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13

StAR-related lipid transfer (START) domain containing 13

chr17_+_40811089 0.404 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr7_-_70360593 0.376 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr12_+_38780817 0.375 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr7_-_30559828 0.372 ENSMUST00000108164.1
Lin37
lin-37 homolog (C. elegans)
chr19_+_53329413 0.370 ENSMUST00000025998.7
Mxi1
Max interacting protein 1
chr11_-_48946148 0.345 ENSMUST00000104958.1
Psme2b
protease (prosome, macropain) activator subunit 2B
chr14_+_84443553 0.317 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr16_-_22439719 0.316 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr1_-_75142360 0.310 ENSMUST00000041213.5
Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr11_-_68386974 0.282 ENSMUST00000135141.1
Ntn1
netrin 1
chr8_-_122476036 0.279 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr8_+_71568866 0.278 ENSMUST00000034267.4
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr1_+_172698046 0.269 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr4_-_128806045 0.246 ENSMUST00000106072.2
ENSMUST00000170934.1
Zfp362

zinc finger protein 362

chr2_+_164486455 0.245 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chrX_+_7878298 0.237 ENSMUST00000033495.8
Pim2
proviral integration site 2
chr10_+_128303322 0.237 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr1_+_36511867 0.228 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr12_-_84698769 0.218 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr1_+_75142775 0.201 ENSMUST00000097694.4
Fam134a
family with sequence similarity 134, member A
chr10_-_5069044 0.191 ENSMUST00000095899.3
Syne1
spectrin repeat containing, nuclear envelope 1
chr10_+_40349265 0.188 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr2_-_164389095 0.180 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr6_+_125009665 0.177 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384




zinc finger protein 384




chr4_-_92191749 0.155 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr2_-_91710519 0.155 ENSMUST00000028678.8
ENSMUST00000076803.5
Atg13

autophagy related 13

chr1_-_74284636 0.153 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr19_-_58455903 0.140 ENSMUST00000131877.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr11_+_19924354 0.126 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr12_+_72761211 0.125 ENSMUST00000021514.8
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
chr11_+_82911253 0.122 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b

unc-45 homolog B (C. elegans)

chr18_-_62756275 0.115 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr3_-_146770218 0.112 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr18_-_39489776 0.102 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr2_+_124610573 0.102 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr2_-_148046896 0.093 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2

forkhead box A2

chr19_-_42086338 0.082 ENSMUST00000051772.8
Morn4
MORN repeat containing 4
chr7_-_65371210 0.082 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr2_+_155517948 0.078 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2


acyl-CoA synthetase short-chain family member 2


chr4_-_137785371 0.060 ENSMUST00000133473.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr10_+_96616998 0.059 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr4_-_134915010 0.053 ENSMUST00000105863.1
ENSMUST00000030626.5
Tmem50a

transmembrane protein 50A

chr1_+_17601893 0.043 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr2_+_91710852 0.043 ENSMUST00000128140.1
ENSMUST00000140183.1
Harbi1

harbinger transposase derived 1

chr7_+_113766119 0.037 ENSMUST00000084696.4
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr15_+_25752860 0.037 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chr9_-_108649349 0.033 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr1_+_74284930 0.031 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr4_-_155345696 0.028 ENSMUST00000103178.4
Prkcz
protein kinase C, zeta
chr2_+_143915273 0.028 ENSMUST00000103172.3
Dstn
destrin
chr2_-_120245157 0.019 ENSMUST00000090071.4
Pla2g4e
phospholipase A2, group IVE
chr11_+_3332426 0.018 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr1_-_163403627 0.016 ENSMUST00000045138.4
Gorab
golgin, RAB6-interacting
chr17_+_24840108 0.009 ENSMUST00000164251.1
Hagh
hydroxyacyl glutathione hydrolase
chr2_+_3513035 0.008 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr11_-_60352869 0.007 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
Tom1l2





target of myb1-like 2 (chicken)





chr9_+_114731177 0.003 ENSMUST00000035007.8
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr7_+_30291659 0.001 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
Clip3


CAP-GLY domain containing linker protein 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.4 1.8 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.4 2.2 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.3 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 0.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 1.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 0.6 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 0.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 1.5 GO:0009109 coenzyme catabolic process(GO:0009109)
0.1 0.4 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 1.5 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.1 0.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) cardiolipin biosynthetic process(GO:0032049) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.3 GO:0045908 negative regulation of vasodilation(GO:0045908)
0.0 0.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 1.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.4 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.3 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.2 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 1.0 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.0 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.0 0.5 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0001851 complement component C3b binding(GO:0001851)
0.5 1.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.3 1.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)