Motif ID: Foxo3

Z-value: 0.613


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.631.5e-02Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_101785252 2.159 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr11_-_100354040 1.795 ENSMUST00000173630.1
 Hap1
huntingtin-associated protein 1
chr14_-_51913393 1.535 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr10_+_112271123 1.512 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr16_+_93683184 1.508 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr3_+_5218546 1.458 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr10_-_49783259 1.335 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr1_-_140183404 1.147 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr4_+_105157339 1.057 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr13_-_23622502 1.043 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr2_-_51972990 1.038 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr7_-_90129339 0.979 ENSMUST00000181189.1
 2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr11_-_94242701 0.971 ENSMUST00000061469.3
 Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr2_-_51973219 0.944 ENSMUST00000028314.2
 Nmi
N-myc (and STAT) interactor
chr3_+_5218516 0.939 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr11_-_68386821 0.898 ENSMUST00000021284.3
 Ntn1
netrin 1
chr7_-_109616548 0.883 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr4_+_94739276 0.820 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chr15_+_79347534 0.814 ENSMUST00000096350.3
 Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr1_-_140183283 0.811 ENSMUST00000111977.1
 Cfh
complement component factor h

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.7 2.0 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.3 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.4 1.8 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.2 1.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 1.5 GO:0009109 coenzyme catabolic process(GO:0009109)
0.1 1.5 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
0.0 1.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.3 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.0 GO:0048747 muscle fiber development(GO:0048747)
0.3 0.8 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 0.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 0.6 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.0 0.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.5 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.4 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.4 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 1.8 GO:0005776 autophagosome(GO:0005776)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.2 1.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 0.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.0 GO:0001851 complement component C3b binding(GO:0001851)
0.2 1.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.5 1.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 1.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 1.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 0.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)