Motif ID: Nkx2-1

Z-value: 0.395


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56535047_565351060.544.6e-02Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_52268337 1.446 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr11_+_85832551 0.796 ENSMUST00000000095.6
 Tbx2
T-box 2
chr8_-_46294592 0.788 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_88978958 0.667 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr15_-_10470490 0.625 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr12_+_103314944 0.515 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr17_-_25570678 0.472 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr14_-_47411666 0.448 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_158146385 0.410 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr17_-_25861456 0.389 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chrX_+_58030999 0.375 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr7_-_29125142 0.348 ENSMUST00000179893.1
ENSMUST00000032813.9
 Ryr1

ryanodine receptor 1, skeletal muscle

chr12_+_78748947 0.345 ENSMUST00000082024.5
 Mpp5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr7_+_51879041 0.337 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr11_+_117849223 0.332 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr7_+_51878967 0.328 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr16_+_48994185 0.322 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr1_-_163725123 0.318 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr11_+_63133068 0.318 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr17_+_47737030 0.318 ENSMUST00000086932.3
 Tfeb
transcription factor EB
chr4_-_109665249 0.300 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr2_+_19344820 0.290 ENSMUST00000150514.1
ENSMUST00000136456.1
 4930447M23Rik

RIKEN cDNA 4930447M23 gene

chr11_+_117849286 0.284 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chrX_+_58030622 0.272 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr17_+_34263209 0.270 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr13_+_55635002 0.261 ENSMUST00000172272.1
ENSMUST00000099479.3
 Ddx46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

chr1_+_75450699 0.251 ENSMUST00000037708.9
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr2_+_10153563 0.250 ENSMUST00000026886.7
 Itih5
inter-alpha (globulin) inhibitor H5
chr1_+_128103297 0.230 ENSMUST00000036288.4
 R3hdm1
R3H domain containing 1
chr7_+_35186370 0.212 ENSMUST00000135452.1
ENSMUST00000001854.5
 Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr1_+_74153981 0.208 ENSMUST00000027372.7
ENSMUST00000106899.2
 Cxcr2

chemokine (C-X-C motif) receptor 2

chr4_-_118490030 0.205 ENSMUST00000047421.5
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr4_+_98923845 0.199 ENSMUST00000091358.4
 Usp1
ubiquitin specific peptidase 1
chrX_+_100730178 0.176 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr6_+_59208870 0.173 ENSMUST00000062626.3
 Tigd2
tigger transposable element derived 2
chr9_-_71896047 0.172 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr2_+_19344317 0.172 ENSMUST00000141289.1
 4930447M23Rik
RIKEN cDNA 4930447M23 gene
chr1_-_181842334 0.164 ENSMUST00000005003.6
 Lbr
lamin B receptor
chrX_+_56346390 0.162 ENSMUST00000101560.3
 Zfp449
zinc finger protein 449
chrX_+_56963325 0.161 ENSMUST00000096431.3
 Gpr112
G protein-coupled receptor 112
chr14_-_30915387 0.157 ENSMUST00000166622.1
 Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr16_+_44139821 0.153 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
 Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr8_+_23411490 0.147 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chrX_-_111463043 0.145 ENSMUST00000065976.5
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr12_-_30911593 0.143 ENSMUST00000062740.7
ENSMUST00000074038.5
 Acp1

acid phosphatase 1, soluble

chr7_-_126200397 0.142 ENSMUST00000009344.9
 Xpo6
exportin 6
chr1_+_75450436 0.141 ENSMUST00000113577.1
 Asic4
acid-sensing (proton-gated) ion channel family member 4
chr2_+_121506748 0.135 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chr4_+_89688196 0.129 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chrX_-_111463103 0.120 ENSMUST00000137712.2
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr11_+_69098937 0.119 ENSMUST00000021271.7
 Per1
period circadian clock 1
chr12_+_55598917 0.119 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr8_+_95703037 0.112 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr9_+_46012810 0.112 ENSMUST00000126865.1
 Sik3
SIK family kinase 3
chr11_-_86257518 0.109 ENSMUST00000136469.1
ENSMUST00000018212.6
 Ints2

integrator complex subunit 2

chr2_+_71981184 0.105 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr2_-_120731503 0.104 ENSMUST00000110701.1
ENSMUST00000110700.1
 Cdan1

congenital dyserythropoietic anemia, type I (human)

chr5_+_128601106 0.099 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr2_+_80315461 0.099 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr9_+_75775355 0.095 ENSMUST00000012281.7
 Bmp5
bone morphogenetic protein 5
chr17_-_56982120 0.095 ENSMUST00000056113.4
 Acer1
alkaline ceramidase 1
chr13_+_12565868 0.095 ENSMUST00000071973.6
 Ero1lb
ERO1-like beta (S. cerevisiae)
chrX_+_7762652 0.094 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
 Tfe3



transcription factor E3



chr2_+_3770673 0.087 ENSMUST00000177037.1
 Fam107b
family with sequence similarity 107, member B
chr7_+_35397046 0.087 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr16_+_24448082 0.087 ENSMUST00000078988.2
 Lpp
LIM domain containing preferred translocation partner in lipoma
chr7_-_45814277 0.086 ENSMUST00000107728.1
 Cyth2
cytohesin 2
chr15_+_99702278 0.084 ENSMUST00000023759.4
 Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr7_-_45814302 0.084 ENSMUST00000107729.1
ENSMUST00000056820.6
 Cyth2

cytohesin 2

chr4_+_120854786 0.084 ENSMUST00000071093.2
 Rims3
regulating synaptic membrane exocytosis 3
chr5_-_115341142 0.083 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr2_-_73775341 0.069 ENSMUST00000112024.3
ENSMUST00000166199.1
ENSMUST00000180045.1
 Chn1


chimerin (chimaerin) 1


chr2_+_69897220 0.068 ENSMUST00000055758.9
ENSMUST00000112251.2
 Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr11_+_70432627 0.062 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
 Arrb2






arrestin, beta 2






chr10_+_85102627 0.061 ENSMUST00000095383.4
 AI597468
expressed sequence AI597468
chr6_-_87851011 0.060 ENSMUST00000113617.1
 Cnbp
cellular nucleic acid binding protein
chr11_-_120086790 0.058 ENSMUST00000106227.1
ENSMUST00000106229.1
ENSMUST00000180242.1
 Azi1


5-azacytidine induced gene 1


chr6_-_101377342 0.057 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr12_-_71136611 0.053 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chrX_-_8132770 0.051 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
 Wdr13



WD repeat domain 13



chr4_-_141874879 0.050 ENSMUST00000036854.3
 Efhd2
EF hand domain containing 2
chr4_+_45203921 0.048 ENSMUST00000107804.1
 Frmpd1
FERM and PDZ domain containing 1
chr11_-_96916448 0.048 ENSMUST00000103152.4
 Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr12_-_84698769 0.043 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr2_-_73892619 0.039 ENSMUST00000112007.1
ENSMUST00000112016.2
 Atf2

activating transcription factor 2

chrX_-_73966329 0.036 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr6_-_82939676 0.034 ENSMUST00000000641.9
ENSMUST00000113982.1
 Sema4f

sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain

chr9_+_119937606 0.033 ENSMUST00000035100.5
 Ttc21a
tetratricopeptide repeat domain 21A
chr7_+_100607410 0.033 ENSMUST00000107048.1
ENSMUST00000032946.3
 Rab6a

RAB6A, member RAS oncogene family

chr4_-_41517326 0.027 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr10_+_22645011 0.026 ENSMUST00000042261.4
 Slc2a12
solute carrier family 2 (facilitated glucose transporter), member 12
chr7_-_28372233 0.025 ENSMUST00000094644.4
 Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr2_-_122118364 0.024 ENSMUST00000036450.7
 Spg11
spastic paraplegia 11
chrX_+_114474312 0.024 ENSMUST00000113371.1
ENSMUST00000040504.5
 Klhl4

kelch-like 4

chr7_+_30563298 0.023 ENSMUST00000043273.9
ENSMUST00000163654.1
ENSMUST00000166510.1
ENSMUST00000163482.1
ENSMUST00000166257.1
ENSMUST00000163464.1
ENSMUST00000171850.1
ENSMUST00000168931.1
 U2af1l4







U2 small nuclear RNA auxiliary factor 1-like 4







chr4_+_62360695 0.023 ENSMUST00000084526.5
 Slc31a1
solute carrier family 31, member 1
chr6_-_41636389 0.023 ENSMUST00000031902.5
 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr14_+_27238018 0.018 ENSMUST00000049206.5
 Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr18_+_49832622 0.018 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr4_+_9269285 0.018 ENSMUST00000038841.7
 Clvs1
clavesin 1
chr7_+_28766747 0.016 ENSMUST00000170068.1
ENSMUST00000072965.4
 Sirt2

sirtuin 2

chr3_+_88532314 0.015 ENSMUST00000172699.1
 Mex3a
mex3 homolog A (C. elegans)
chrX_-_142390334 0.014 ENSMUST00000112907.1
 Acsl4
acyl-CoA synthetase long-chain family member 4
chr10_-_123196916 0.014 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr18_-_36670269 0.014 ENSMUST00000006209.4
 Sra1
steroid receptor RNA activator 1
chr1_-_56969864 0.013 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_8819401 0.011 ENSMUST00000096753.3
 Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr3_-_108200807 0.008 ENSMUST00000106655.1
ENSMUST00000065664.6
 Cyb561d1

cytochrome b-561 domain containing 1

chr17_-_32388885 0.003 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr19_+_44493472 0.002 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.2 1.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.2 0.5 GO:0072034 renal vesicle induction(GO:0072034)
0.1 0.4 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 0.3 GO:0002339 B cell selection(GO:0002339)
0.1 0.3 GO:0071415 cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.1 0.2 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 0.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.7 GO:0032288 myelin assembly(GO:0032288)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0060179 male mating behavior(GO:0060179)
0.0 0.1 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:2001135 regulation of endocytic recycling(GO:2001135)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.4 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)