Motif ID: Nkx2-1

Z-value: 0.395


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56535047_565351060.544.6e-02Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_52268337 1.446 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr11_+_85832551 0.796 ENSMUST00000000095.6
 Tbx2
T-box 2
chr8_-_46294592 0.788 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr15_-_88978958 0.667 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr15_-_10470490 0.625 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr12_+_103314944 0.515 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr17_-_25570678 0.472 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr14_-_47411666 0.448 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_158146385 0.410 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr17_-_25861456 0.389 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chrX_+_58030999 0.375 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr7_-_29125142 0.348 ENSMUST00000179893.1
ENSMUST00000032813.9
 Ryr1

ryanodine receptor 1, skeletal muscle

chr12_+_78748947 0.345 ENSMUST00000082024.5
 Mpp5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr7_+_51879041 0.337 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr11_+_117849223 0.332 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr7_+_51878967 0.328 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr16_+_48994185 0.322 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr1_-_163725123 0.318 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr11_+_63133068 0.318 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr17_+_47737030 0.318 ENSMUST00000086932.3
 Tfeb
transcription factor EB

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 0.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.7 GO:0032288 myelin assembly(GO:0032288)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.6 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 0.5 GO:0072034 renal vesicle induction(GO:0072034)
0.1 0.4 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.3 GO:0002339 B cell selection(GO:0002339)
0.1 0.3 GO:0071415 cellular response to caffeine(GO:0071313) cellular response to purine-containing compound(GO:0071415)
0.0 0.3 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 0.2 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 0.2 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0005272 sodium channel activity(GO:0005272)
0.1 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.0 0.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)