Motif ID: Nfkb2

Z-value: 1.060


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_46304811-0.273.4e-01Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_153740344 5.340 ENSMUST00000027748.7
 Rgs16
regulator of G-protein signaling 16
chr11_-_33147400 4.605 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr14_-_30607808 3.516 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr14_-_30626196 3.200 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr2_+_172550761 2.144 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr2_+_172550991 1.993 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr7_+_29289300 1.864 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_74791516 1.567 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr19_+_7268296 1.418 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chrX_+_163909132 1.397 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chrX_+_163908982 1.276 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_54962903 1.059 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr11_-_70656467 0.995 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr1_+_167001457 0.939 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr5_+_110544326 0.884 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr15_-_102246439 0.724 ENSMUST00000063339.7
 Rarg
retinoic acid receptor, gamma
chr3_-_107760221 0.691 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr3_-_116424007 0.690 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 0.677 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr1_+_167001417 0.670 ENSMUST00000165874.1
 Fam78b
family with sequence similarity 78, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.7 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.0 5.3 GO:0043547 positive regulation of GTPase activity(GO:0043547)
1.2 4.6 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
1.4 4.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 2.8 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.7 GO:0035690 cellular response to drug(GO:0035690)
0.2 1.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 1.4 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 0.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.5 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.5 GO:0010842 retina layer formation(GO:0010842)
0.1 0.4 GO:0045472 response to ether(GO:0045472) negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of tumor necrosis factor secretion(GO:1904468)
0.1 0.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.3 GO:0006903 vesicle targeting(GO:0006903)
0.1 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 5.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 0.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 0.5 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0042613 MHC class II protein complex(GO:0042613)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 6.7 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.0 5.5 GO:0005096 GTPase activator activity(GO:0005096)
1.5 4.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 4.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 3.0 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.9 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 0.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.5 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.2 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0042556 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)