Motif ID: Hoxd8

Z-value: 0.441


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_48432723 0.599 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr1_-_158814469 0.383 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr6_+_34384218 0.371 ENSMUST00000038383.7
ENSMUST00000115051.1
 Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr1_+_9547948 0.360 ENSMUST00000144177.1
 Adhfe1
alcohol dehydrogenase, iron containing, 1
chr12_-_90969768 0.355 ENSMUST00000181184.1
 4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr9_+_80165013 0.338 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr3_-_19264959 0.335 ENSMUST00000121951.1
 Pde7a
phosphodiesterase 7A
chr4_+_101986626 0.298 ENSMUST00000106914.1
 Gm12789
predicted gene 12789
chr4_+_118961578 0.298 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr8_+_34054622 0.293 ENSMUST00000149618.1
 Gm9951
predicted gene 9951
chr3_+_127633134 0.288 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr13_-_85127514 0.275 ENSMUST00000179230.1
 Gm4076
predicted gene 4076
chr1_-_172027269 0.266 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_+_76075583 0.258 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr14_+_55559993 0.231 ENSMUST00000117236.1
 Dcaf11
DDB1 and CUL4 associated factor 11
chr6_+_71282280 0.213 ENSMUST00000080949.7
 Krcc1
lysine-rich coiled-coil 1
chr5_-_73191848 0.208 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr11_+_109543694 0.201 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr1_-_138848576 0.186 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr5_+_48372363 0.163 ENSMUST00000030968.2
 Pacrgl
PARK2 co-regulated-like
chr3_+_95871519 0.159 ENSMUST00000120398.1
 C920021L13Rik
RIKEN cDNA C920021L13 gene
chr14_+_55560010 0.155 ENSMUST00000147981.1
ENSMUST00000133256.1
 Dcaf11

DDB1 and CUL4 associated factor 11

chr9_+_80165079 0.155 ENSMUST00000184480.1
 Myo6
myosin VI
chr2_-_73580288 0.148 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr18_+_11633276 0.141 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr7_-_80405425 0.126 ENSMUST00000107362.3
ENSMUST00000135306.1
 Furin

furin (paired basic amino acid cleaving enzyme)

chr15_-_35155750 0.123 ENSMUST00000067033.7
ENSMUST00000018476.7
 Stk3

serine/threonine kinase 3

chr5_-_38491948 0.122 ENSMUST00000129099.1
 Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr9_-_15301555 0.121 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr3_+_94372794 0.121 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr17_-_34862473 0.117 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
 Cfb


complement factor B


chr10_+_103367748 0.116 ENSMUST00000074204.4
ENSMUST00000179636.1
 Slc6a15

solute carrier family 6 (neurotransmitter transporter), member 15

chr3_-_96197580 0.115 ENSMUST00000016087.3
 Bola1
bolA-like 1 (E. coli)
chr10_-_76110956 0.113 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr6_+_134640940 0.104 ENSMUST00000062755.8
 Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr19_-_19001099 0.104 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr9_+_72806874 0.100 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr10_+_23797052 0.099 ENSMUST00000133289.1
 Slc18b1
solute carrier family 18, subfamily B, member 1
chrX_-_74393003 0.094 ENSMUST00000015427.6
 Fam3a
family with sequence similarity 3, member A
chr5_-_121527186 0.093 ENSMUST00000152270.1
 Mapkapk5
MAP kinase-activated protein kinase 5
chr4_-_132398199 0.089 ENSMUST00000136711.1
ENSMUST00000084249.4
 Phactr4

phosphatase and actin regulator 4

chr12_-_84617326 0.083 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr7_+_39588931 0.078 ENSMUST00000178791.1
ENSMUST00000098511.3
 Gm2058

predicted gene 2058

chr10_-_127030813 0.077 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr12_-_12940600 0.074 ENSMUST00000130990.1
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr5_-_111761697 0.073 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr7_-_45062393 0.072 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr9_-_57158288 0.069 ENSMUST00000065358.7
 Commd4
COMM domain containing 4
chr9_+_54980880 0.067 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr14_+_58893465 0.064 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr15_+_81744848 0.059 ENSMUST00000109554.1
 Zc3h7b
zinc finger CCCH type containing 7B
chr2_+_152669461 0.058 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
 H13



histocompatibility 13



chr7_-_29906524 0.056 ENSMUST00000159920.1
ENSMUST00000162592.1
 Zfp27

zinc finger protein 27

chr12_-_87444017 0.055 ENSMUST00000091090.4
 2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr2_-_66410064 0.052 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr11_+_117809653 0.047 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr5_+_107497718 0.046 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr2_-_160619971 0.043 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr11_+_78037959 0.040 ENSMUST00000073660.6
 Flot2
flotillin 2
chr8_-_84662841 0.040 ENSMUST00000060427.4
 Ier2
immediate early response 2
chr1_+_178405881 0.038 ENSMUST00000027775.7
 Efcab2
EF-hand calcium binding domain 2
chr12_-_54695885 0.037 ENSMUST00000067272.8
 Eapp
E2F-associated phosphoprotein
chr3_+_88716884 0.035 ENSMUST00000172252.1
 Rit1
Ras-like without CAAX 1
chr3_-_19265007 0.033 ENSMUST00000091314.4
 Pde7a
phosphodiesterase 7A
chr11_+_78037931 0.032 ENSMUST00000072289.5
ENSMUST00000100784.2
 Flot2

flotillin 2

chr2_+_152687137 0.032 ENSMUST00000062148.6
 Mcts2
malignant T cell amplified sequence 2
chr18_+_60774675 0.032 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr12_-_54695829 0.029 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
 Eapp



E2F-associated phosphoprotein



chr3_+_24333046 0.028 ENSMUST00000077389.6
 Gm7536
predicted gene 7536
chr8_-_106573461 0.027 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr10_+_116177351 0.024 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr17_+_34647128 0.024 ENSMUST00000015605.8
ENSMUST00000182587.1
 Atf6b

activating transcription factor 6 beta

chr7_+_45062429 0.024 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
 Nosip



nitric oxide synthase interacting protein



chr7_+_126976338 0.019 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr2_-_140671462 0.014 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_-_127840290 0.014 ENSMUST00000061512.2
 Map3k19
mitogen-activated protein kinase kinase kinase 19
chr5_+_24394388 0.012 ENSMUST00000115074.1
 Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chrX_+_20662898 0.010 ENSMUST00000001989.8
 Uba1
ubiquitin-like modifier activating enzyme 1
chr17_+_34647187 0.009 ENSMUST00000173984.1
 Atf6b
activating transcription factor 6 beta
chr10_-_63927434 0.009 ENSMUST00000079279.3
 Gm10118
predicted gene 10118
chr14_+_47298260 0.008 ENSMUST00000166743.1
 Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr8_+_33599608 0.008 ENSMUST00000009774.9
 Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr19_-_33761949 0.005 ENSMUST00000025694.6
ENSMUST00000147153.1
 Lipo1
Lipo2
lipase, member O1
lipase, member O2
chr5_+_92809372 0.003 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr13_-_58354862 0.002 ENSMUST00000043605.5
 Kif27
kinesin family member 27

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.5 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.6 GO:0016556 mRNA modification(GO:0016556)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.1 GO:0032911 nerve growth factor production(GO:0032902) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.1 GO:0046549 retinal cone cell development(GO:0046549)
0.0 0.1 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.4 GO:0052650 retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.0 0.2 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)