Motif ID: Nkx2-2
Z-value: 1.500
Transcription factors associated with Nkx2-2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-2 | ENSMUSG00000027434.10 | Nkx2-2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-2 | mm10_v2_chr2_-_147186389_147186413 | 0.28 | 3.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.5 | 1.4 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.4 | 2.2 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.3 | 1.6 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.3 | 0.9 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.3 | 1.1 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.2 | 1.9 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
| 0.2 | 0.6 | GO:0051542 | elastin biosynthetic process(GO:0051542) |
| 0.2 | 0.6 | GO:0002586 | regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002580) positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499) |
| 0.2 | 1.0 | GO:0006046 | N-acetylglucosamine catabolic process(GO:0006046) |
| 0.2 | 0.7 | GO:0034454 | microtubule anchoring at centrosome(GO:0034454) |
| 0.2 | 2.3 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.2 | 0.5 | GO:0006295 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) positive regulation of t-circle formation(GO:1904431) |
| 0.2 | 0.6 | GO:0071726 | response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) |
| 0.1 | 0.4 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.1 | 0.9 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 0.5 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.3 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.3 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.1 | 0.3 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
| 0.1 | 0.4 | GO:1903463 | mitotic cell cycle phase(GO:0098763) regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.1 | 0.8 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 2.7 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 0.3 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.1 | 0.3 | GO:0046078 | deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078) |
| 0.1 | 0.4 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.1 | 0.2 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.1 | 0.5 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
| 0.1 | 1.9 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 1.8 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 0.2 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.1 | 0.3 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 0.3 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.1 | 0.7 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.1 | 0.4 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.1 | 0.8 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.0 | 0.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.1 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.0 | 0.7 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 0.2 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.0 | 0.7 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.0 | 0.3 | GO:0009072 | aromatic amino acid family metabolic process(GO:0009072) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.2 | GO:0043173 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) nucleotide salvage(GO:0043173) |
| 0.0 | 0.8 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.8 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.3 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.0 | 0.3 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.2 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 1.0 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.4 | GO:0051384 | response to glucocorticoid(GO:0051384) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.2 | 0.9 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.2 | 0.7 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.2 | 0.5 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522) |
| 0.1 | 2.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.1 | 0.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.5 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 1.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 1.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 0.3 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.1 | 0.8 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.2 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.0 | 2.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.4 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 2.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.5 | GO:0043205 | fibril(GO:0043205) |
| 0.0 | 0.7 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.3 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 0.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.3 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.3 | 2.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 1.2 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.3 | 2.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.3 | 1.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 2.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.2 | 0.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 0.6 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.2 | 1.0 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.2 | 1.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 0.9 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 0.8 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 1.9 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 0.3 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 1.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 0.5 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.4 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.1 | 0.4 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 0.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.3 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 1.9 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 1.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 3.0 | GO:0043851 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012) |
| 0.0 | 0.3 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) |
| 0.0 | 0.5 | GO:0016595 | glutamate binding(GO:0016595) |
| 0.0 | 0.4 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 0.2 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
| 0.0 | 0.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 1.0 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 0.3 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
