Motif ID: Nkx2-2

Z-value: 1.500


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.283.3e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_19418930 5.204 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 4.755 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3017408 4.639 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3025417 4.569 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 4.545 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 4.281 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3005125 4.253 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr3_+_118433797 3.984 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr10_+_106470281 2.332 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr3_-_59220150 2.243 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr4_+_59626189 2.176 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr15_-_10470490 1.990 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr3_+_52268337 1.905 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr7_+_112374839 1.887 ENSMUST00000106645.1
 Micalcl
MICAL C-terminal like
chr9_-_4796218 1.881 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
 Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr4_+_46039202 1.595 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr2_-_140170528 1.588 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr12_+_74297474 1.562 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr4_+_62619515 1.478 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr10_-_54075730 1.414 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0006491 N-glycan processing(GO:0006491)
0.2 2.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.7 2.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 2.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.2 1.9 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 1.9 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 1.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 1.6 GO:0031033 myosin filament organization(GO:0031033)
0.5 1.4 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.4 GO:0007605 sensory perception of sound(GO:0007605)
0.3 1.1 GO:0035617 stress granule disassembly(GO:0035617)
0.2 1.0 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.3 0.9 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.9 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.8 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.8 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.4 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.3 1.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.4 GO:0070469 respiratory chain(GO:0070469)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.2 0.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.8 GO:0033269 internode region of axon(GO:0033269)
0.1 0.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)
0.2 0.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 0.5 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.5 GO:0043205 fibril(GO:0043205)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.3 2.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.4 2.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.3 2.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 2.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.3 1.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 1.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.0 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.2 0.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.2 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)