Motif ID: Hoxb8_Pdx1
Z-value: 0.768
Transcription factors associated with Hoxb8_Pdx1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxb8 | ENSMUSG00000056648.4 | Hoxb8 |
Pdx1 | ENSMUSG00000029644.6 | Pdx1 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
0.5 | 1.8 | GO:0055095 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
0.4 | 3.4 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
0.4 | 5.4 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.3 | 1.0 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
0.2 | 0.7 | GO:0048211 | Golgi vesicle docking(GO:0048211) |
0.2 | 0.7 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.2 | 0.9 | GO:0060032 | notochord regression(GO:0060032) |
0.2 | 2.1 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.2 | 3.4 | GO:0021860 | pyramidal neuron development(GO:0021860) |
0.2 | 1.7 | GO:0060373 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
0.2 | 2.4 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.2 | 2.4 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
0.2 | 0.3 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
0.1 | 0.7 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.8 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
0.1 | 0.8 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.1 | 1.0 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.1 | 0.6 | GO:1900242 | regulation of synaptic vesicle endocytosis(GO:1900242) |
0.1 | 0.9 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
0.1 | 1.0 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 1.7 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
0.1 | 1.3 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
0.1 | 0.5 | GO:0051013 | microtubule severing(GO:0051013) |
0.1 | 0.4 | GO:0019659 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
0.1 | 1.8 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
0.1 | 0.6 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
0.1 | 0.6 | GO:0034720 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) histone H3-K4 demethylation(GO:0034720) mammary duct terminal end bud growth(GO:0060763) |
0.1 | 0.2 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
0.1 | 1.6 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
0.1 | 0.5 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.1 | 0.2 | GO:0000733 | DNA strand renaturation(GO:0000733) |
0.1 | 0.2 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
0.0 | 0.4 | GO:0060484 | lung-associated mesenchyme development(GO:0060484) |
0.0 | 0.1 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915) |
0.0 | 1.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.0 | 0.3 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) |
0.0 | 0.6 | GO:0032506 | cytokinetic process(GO:0032506) |
0.0 | 0.2 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.0 | 3.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.0 | 0.1 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
0.0 | 0.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.0 | 0.7 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
0.0 | 0.3 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
0.0 | 0.5 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
0.0 | 0.2 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
0.0 | 0.5 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
0.0 | 0.4 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
0.0 | 0.6 | GO:0045725 | positive regulation of glycogen biosynthetic process(GO:0045725) |
0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.0 | 0.2 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
0.0 | 0.2 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 1.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.2 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
0.0 | 0.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 0.1 | GO:0043987 | histone-serine phosphorylation(GO:0035404) histone H3-S10 phosphorylation(GO:0043987) |
0.0 | 0.2 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 0.2 | GO:0017121 | phospholipid scrambling(GO:0017121) |
0.0 | 0.1 | GO:0051030 | snRNA transport(GO:0051030) |
0.0 | 0.3 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
0.0 | 0.1 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.0 | 0.1 | GO:0031622 | positive regulation of fever generation(GO:0031622) negative regulation of action potential(GO:0045759) |
0.0 | 0.1 | GO:2000574 | regulation of microtubule motor activity(GO:2000574) |
0.0 | 0.2 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
0.0 | 0.2 | GO:0016322 | neuron remodeling(GO:0016322) |
0.0 | 1.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 0.1 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
0.0 | 0.5 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
0.0 | 0.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.0 | 0.3 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.0 | 0.0 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
0.0 | 0.2 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
0.0 | 0.6 | GO:0042168 | heme metabolic process(GO:0042168) |
0.0 | 0.2 | GO:0010715 | regulation of extracellular matrix disassembly(GO:0010715) |
0.0 | 1.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.0 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
0.0 | 0.2 | GO:0007097 | nuclear migration(GO:0007097) |
0.0 | 0.6 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
0.0 | 0.3 | GO:0010842 | retina layer formation(GO:0010842) |
0.0 | 0.2 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
0.0 | 0.0 | GO:0046689 | response to mercury ion(GO:0046689) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:1990635 | proximal dendrite(GO:1990635) |
0.3 | 1.0 | GO:0048179 | activin receptor complex(GO:0048179) |
0.2 | 5.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.2 | 0.7 | GO:0072534 | perineuronal net(GO:0072534) |
0.2 | 0.6 | GO:0005899 | insulin receptor complex(GO:0005899) |
0.2 | 1.1 | GO:0008091 | spectrin(GO:0008091) |
0.1 | 1.3 | GO:0043083 | synaptic cleft(GO:0043083) |
0.1 | 1.7 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.1 | 0.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 0.9 | GO:0097542 | ciliary tip(GO:0097542) |
0.1 | 0.3 | GO:0044308 | axonal spine(GO:0044308) |
0.1 | 3.1 | GO:0044295 | axonal growth cone(GO:0044295) |
0.1 | 2.1 | GO:0043034 | costamere(GO:0043034) |
0.1 | 0.6 | GO:0070938 | contractile ring(GO:0070938) |
0.0 | 0.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.6 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.0 | 1.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 3.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 0.5 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.0 | 0.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
0.0 | 0.2 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 2.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 0.1 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
0.0 | 0.1 | GO:0031523 | Myb complex(GO:0031523) |
0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.3 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.1 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500) |
0.0 | 0.2 | GO:0097470 | ribbon synapse(GO:0097470) |
0.0 | 1.0 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.1 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
0.0 | 0.2 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 0.2 | GO:0005682 | U5 snRNP(GO:0005682) |
0.0 | 0.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 0.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.7 | GO:0055100 | adiponectin binding(GO:0055100) |
0.3 | 2.1 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.3 | 1.0 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
0.3 | 0.8 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.2 | 1.7 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.2 | 0.6 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
0.2 | 6.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 3.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 0.4 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
0.1 | 3.0 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 1.3 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
0.1 | 0.6 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.1 | 2.2 | GO:0070402 | NADPH binding(GO:0070402) |
0.1 | 0.4 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.1 | 2.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.1 | 0.6 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
0.1 | 0.3 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
0.1 | 0.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
0.1 | 0.2 | GO:0030620 | U2 snRNA binding(GO:0030620) |
0.1 | 0.4 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.1 | 0.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.1 | 2.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.6 | GO:1990459 | transferrin receptor binding(GO:1990459) |
0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.2 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
0.0 | 0.1 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.7 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
0.0 | 0.5 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.0 | 0.8 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.0 | 0.4 | GO:0050692 | DBD domain binding(GO:0050692) |
0.0 | 1.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.3 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.1 | GO:0035175 | histone kinase activity (H3-S10 specific)(GO:0035175) |
0.0 | 0.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.4 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.0 | 0.1 | GO:0047598 | 7-dehydrocholesterol reductase activity(GO:0047598) |
0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
0.0 | 0.1 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
0.0 | 0.3 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
0.0 | 0.1 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.0 | 0.8 | GO:0018602 | sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635) |
0.0 | 0.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.0 | 0.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.2 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
0.0 | 1.9 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.0 | 0.0 | GO:0004335 | galactokinase activity(GO:0004335) |
0.0 | 0.2 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.0 | 0.2 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.0 | 0.3 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.0 | 0.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |