Motif ID: Hoxb8_Pdx1

Z-value: 0.768

Transcription factors associated with Hoxb8_Pdx1:

Gene SymbolEntrez IDGene Name
Hoxb8 ENSMUSG00000056648.4 Hoxb8
Pdx1 ENSMUSG00000029644.6 Pdx1



Activity profile for motif Hoxb8_Pdx1.

activity profile for motif Hoxb8_Pdx1


Sorted Z-values histogram for motif Hoxb8_Pdx1

Sorted Z-values for motif Hoxb8_Pdx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb8_Pdx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_99044414 3.360 ENSMUST00000177507.1
ENSMUST00000123992.1
 Foxp1

forkhead box P1

chrX_+_140367494 2.433 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr1_+_153665274 2.403 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chrX_-_143933089 2.365 ENSMUST00000087313.3
 Dcx
doublecortin
chr3_+_65109343 2.203 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chrX_-_43274786 2.057 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr6_-_52012476 2.012 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr8_+_118283719 1.833 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr1_-_126830786 1.807 ENSMUST00000162646.1
 Nckap5
NCK-associated protein 5
chr13_+_48513570 1.773 ENSMUST00000065465.1
 A830005F24Rik
RIKEN cDNA A830005F24 gene
chr4_+_102421518 1.684 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr4_+_102589687 1.679 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_126830632 1.615 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr13_+_93304799 1.421 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr6_-_138421379 1.383 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr6_-_136173492 1.315 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr7_+_35802593 1.222 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr13_-_48513394 1.174 ENSMUST00000177530.1
ENSMUST00000176996.1
ENSMUST00000176949.1
ENSMUST00000176176.1
 Zfp169



zinc finger protein 169



chr19_+_4711153 1.135 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr2_-_140671440 1.130 ENSMUST00000099301.1
 Flrt3
fibronectin leucine rich transmembrane protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 3.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 3.4 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 3.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 2.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.2 2.4 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 2.4 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.2 2.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 1.8 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 1.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.7 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 1.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 1.6 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 1.4 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 1.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 1.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.4 2.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.1 GO:0043034 costamere(GO:0043034)
0.1 1.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.1 GO:0008091 spectrin(GO:0008091)
0.3 1.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.1 0.9 GO:0097542 ciliary tip(GO:0097542)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.7 GO:0072534 perineuronal net(GO:0072534)
0.2 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.6 GO:0070938 contractile ring(GO:0070938)
0.0 0.6 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 3.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.2 GO:0070402 NADPH binding(GO:0070402)
0.3 2.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 1.7 GO:0055100 adiponectin binding(GO:0055100)
0.2 1.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.3 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 1.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 0.8 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0018602 sulfonate dioxygenase activity(GO:0000907) 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity(GO:0018602) hypophosphite dioxygenase activity(GO:0034792) gibberellin 2-beta-dioxygenase activity(GO:0045543) C-19 gibberellin 2-beta-dioxygenase activity(GO:0052634) C-20 gibberellin 2-beta-dioxygenase activity(GO:0052635)
0.1 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.7 GO:0031748 D1 dopamine receptor binding(GO:0031748)