Motif ID: Spib

Z-value: 1.469


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 184 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136886187 7.942 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr4_-_136892867 7.751 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136898803 7.247 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr1_-_171059390 6.753 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr1_-_171234290 6.423 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr3_-_87263518 5.180 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_170976112 4.937 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr4_+_130913120 4.219 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr2_+_14229390 4.132 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr3_-_87263703 3.708 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr4_+_130913264 3.521 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr15_+_103453782 3.207 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr19_-_11336107 3.078 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr19_+_12460749 2.734 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr9_+_94669876 2.661 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr14_-_70207637 2.480 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr4_+_136143497 2.444 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr11_+_61653259 2.397 ENSMUST00000004959.2
 Grap
GRB2-related adaptor protein
chr16_-_36666067 2.363 ENSMUST00000089620.4
 Cd86
CD86 antigen
chr16_+_36934976 2.308 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 22.9 GO:0006958 complement activation, classical pathway(GO:0006958)
5.0 14.9 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.6 4.9 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.1 3.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
1.1 3.2 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.8 3.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 2.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 2.6 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 2.5 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.5 2.4 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.3 2.3 GO:0070253 somatostatin secretion(GO:0070253)
0.3 2.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 2.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 2.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 2.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.8 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.3 1.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 23.3 GO:0005581 collagen trimer(GO:0005581)
0.1 21.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.5 GO:0010008 endosome membrane(GO:0010008)
0.2 3.1 GO:0031209 SCAR complex(GO:0031209)
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.7 GO:0055037 recycling endosome(GO:0055037)
0.1 1.9 GO:0002102 podosome(GO:0002102)
0.0 1.7 GO:0043679 axon terminus(GO:0043679)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.3 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.7 GO:0071203 WASH complex(GO:0071203)
0.1 0.6 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.1 0.6 GO:0008278 cohesin complex(GO:0008278)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 19.9 GO:0019864 IgG binding(GO:0019864)
0.3 4.4 GO:0005537 mannose binding(GO:0005537)
0.0 3.7 GO:0019209 kinase activator activity(GO:0019209)
0.0 3.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.9 GO:0017124 SH3 domain binding(GO:0017124)
0.3 2.7 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 2.5 GO:0017166 vinculin binding(GO:0017166)
0.1 2.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.2 GO:0005504 fatty acid binding(GO:0005504)
0.5 2.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 2.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 2.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 1.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.5 GO:0020037 heme binding(GO:0020037)
0.1 1.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.2 GO:0051525 NFAT protein binding(GO:0051525)
0.1 1.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)