Motif ID: Lhx3

Z-value: 0.789


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_49608030 2.189 ENSMUST00000021822.5
 Ogn
osteoglycin
chr7_-_103827922 1.290 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chrM_+_9452 1.161 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr7_-_45103747 1.118 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_+_145585166 1.081 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr10_+_75037291 1.019 ENSMUST00000139384.1
 Rab36
RAB36, member RAS oncogene family
chr3_+_151437887 0.998 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr8_-_21906412 0.989 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr3_+_41742615 0.828 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr17_-_48432723 0.819 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_-_41742471 0.798 ENSMUST00000026866.8
 Sclt1
sodium channel and clathrin linker 1
chr4_+_147132038 0.797 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chr11_+_109543694 0.784 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chrM_-_14060 0.746 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr2_+_36230426 0.682 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr2_+_125136692 0.638 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr4_+_136143497 0.631 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chrM_+_9870 0.620 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr10_-_6980376 0.615 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_153665587 0.605 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr2_+_82053222 0.589 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chrM_+_14138 0.568 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr4_-_147809788 0.532 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr4_+_146610961 0.518 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr1_+_153665666 0.517 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr14_-_48665098 0.502 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_153665627 0.487 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr3_+_122419772 0.484 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr12_-_84617326 0.480 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr10_-_62507737 0.451 ENSMUST00000020271.6
 Srgn
serglycin
chr2_+_110597298 0.431 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr13_-_58354862 0.427 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr2_+_23069210 0.423 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr1_-_158356258 0.423 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr13_-_74482943 0.408 ENSMUST00000074369.6
 Zfp825
zinc finger protein 825
chr3_+_66985680 0.401 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr1_-_24612700 0.375 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr10_+_75037066 0.374 ENSMUST00000147802.1
ENSMUST00000020391.5
 Rab36

RAB36, member RAS oncogene family

chr18_+_57468478 0.368 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr4_+_118961578 0.346 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr13_-_101692624 0.333 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr13_+_93304066 0.331 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr10_-_64090265 0.326 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_+_102158858 0.312 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr15_+_98571004 0.307 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr5_-_51553896 0.301 ENSMUST00000132734.1
 Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr12_+_71170589 0.283 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr19_+_20601958 0.266 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr3_-_57294880 0.256 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr2_-_84425258 0.254 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr4_+_145510759 0.245 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr17_+_45734506 0.240 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr10_-_64090241 0.231 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_+_147492417 0.227 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr10_-_76110956 0.226 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr10_-_53647080 0.218 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr10_+_5593718 0.215 ENSMUST00000051809.8
 Myct1
myc target 1
chr3_+_136670076 0.213 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr5_-_62766153 0.210 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_+_124304646 0.181 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr2_+_163658370 0.174 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
 Pkig





protein kinase inhibitor, gamma





chr8_-_109251698 0.168 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chrX_+_9885622 0.156 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr17_-_56036546 0.141 ENSMUST00000003268.9
 Sh3gl1
SH3-domain GRB2-like 1
chrX_-_94123087 0.130 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr19_+_3768112 0.130 ENSMUST00000005518.9
ENSMUST00000113967.1
ENSMUST00000152935.1
ENSMUST00000176262.1
ENSMUST00000176407.1
ENSMUST00000176926.1
ENSMUST00000176512.1
 Suv420h1






suppressor of variegation 4-20 homolog 1 (Drosophila)






chr10_-_37138863 0.123 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr10_-_33624587 0.118 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chrX_-_143933204 0.115 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_139871637 0.107 ENSMUST00000033811.7
ENSMUST00000087401.5
 Morc4

microrchidia 4

chr3_+_142620596 0.099 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr11_-_84069179 0.095 ENSMUST00000138208.1
 Dusp14
dual specificity phosphatase 14
chr16_-_55934797 0.089 ENSMUST00000122280.1
ENSMUST00000121703.2
 Cep97

centrosomal protein 97

chr1_-_36273425 0.085 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr16_-_55934845 0.084 ENSMUST00000121129.1
ENSMUST00000023270.7
 Cep97

centrosomal protein 97

chr6_+_37870786 0.074 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chrX_+_100625737 0.073 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr3_-_116712644 0.064 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr4_-_58499398 0.059 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr18_+_60774675 0.059 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr16_-_64771146 0.052 ENSMUST00000076991.6
 4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr14_+_80000292 0.046 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr5_-_70842617 0.035 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr18_+_60774510 0.034 ENSMUST00000025511.3
 Rps14
ribosomal protein S14
chrX_+_166344692 0.027 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr14_-_96519067 0.023 ENSMUST00000022666.7
 Klhl1
kelch-like 1
chr7_-_37772868 0.012 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr3_+_66985647 0.011 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_95318782 0.009 ENSMUST00000139866.1
 Cers2
ceramide synthase 2
chr8_-_106573461 0.005 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.2 0.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 1.6 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 0.6 GO:0033762 response to glucagon(GO:0033762)
0.1 0.3 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.3 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.3 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.8 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.6 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0 1.2 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.6 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0060746 parental behavior(GO:0060746)
0.0 0.4 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.2 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 0.6 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.0 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 2.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0019770 IgG receptor activity(GO:0019770)
0.3 1.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.8 GO:0018741 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1 0.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 2.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.3 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 1.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)