Motif ID: Pitx1

Z-value: 0.718


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_99298652 2.335 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr4_-_64046925 2.102 ENSMUST00000107377.3
 Tnc
tenascin C
chrX_+_169879596 1.846 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr1_+_167598450 1.755 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr4_+_144892813 1.699 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chrX_+_169685191 1.674 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr3_+_95526777 1.554 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr4_+_144893077 1.432 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_21993890 1.361 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr6_+_108213086 1.351 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr1_+_167598384 1.315 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr19_+_8617991 1.283 ENSMUST00000010250.2
 Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr13_-_97747373 1.181 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr15_-_79164477 1.165 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr4_+_144893127 1.131 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr19_-_47919269 1.119 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr8_-_46294592 1.118 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr8_+_127063893 1.100 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr8_+_127064022 1.066 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr7_-_4752972 1.021 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.3 GO:0042572 retinol metabolic process(GO:0042572)
0.1 3.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 3.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.3 2.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 2.2 GO:0003383 apical constriction(GO:0003383)
0.4 1.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 1.5 GO:0010447 response to acidic pH(GO:0010447)
0.2 1.4 GO:0042045 epithelial fluid transport(GO:0042045)
0.2 1.4 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 1.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.2 GO:0048484 enteric nervous system development(GO:0048484)
0.1 1.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 1.1 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 1.0 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 1.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 0.8 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.2 0.7 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.2 0.6 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.2 GO:0033269 internode region of axon(GO:0033269)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.5 1.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 1.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.0 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.3 GO:0097227 sperm annulus(GO:0097227)
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 4.0 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.3 3.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 2.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 2.1 GO:0045545 syndecan binding(GO:0045545)
0.0 1.9 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.5 1.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3 1.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)