Motif ID: Tbx1_Eomes
Z-value: 1.345
Transcription factors associated with Tbx1_Eomes:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Eomes | ENSMUSG00000032446.8 | Eomes |
Tbx1 | ENSMUSG00000009097.9 | Tbx1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Eomes | mm10_v2_chr9_+_118478851_118478866 | 0.89 | 2.0e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 9.6 | GO:0051866 | general adaptation syndrome(GO:0051866) |
2.0 | 22.3 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
1.6 | 19.3 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.9 | 2.8 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
0.8 | 2.4 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
0.8 | 2.3 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.6 | 4.0 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
0.5 | 1.6 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
0.5 | 5.9 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.5 | 1.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.4 | 1.3 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.4 | 1.2 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.3 | 1.3 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.3 | 1.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.3 | 1.7 | GO:0046549 | retinal cone cell development(GO:0046549) |
0.3 | 1.0 | GO:0015871 | choline transport(GO:0015871) |
0.2 | 6.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.2 | 10.3 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.2 | 0.6 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.2 | 0.6 | GO:0090526 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.2 | 1.0 | GO:0002158 | osteoclast proliferation(GO:0002158) |
0.2 | 0.5 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
0.2 | 0.9 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.2 | 0.8 | GO:0007171 | cardiac conduction system development(GO:0003161) activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) |
0.1 | 0.5 | GO:0061030 | axon target recognition(GO:0007412) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
0.1 | 0.9 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 1.3 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) |
0.1 | 0.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.1 | 1.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 1.1 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
0.1 | 0.5 | GO:0035262 | gonad morphogenesis(GO:0035262) |
0.1 | 1.6 | GO:0003334 | keratinocyte development(GO:0003334) |
0.1 | 0.3 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
0.1 | 0.2 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
0.1 | 0.3 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
0.1 | 1.9 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.1 | 0.6 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
0.1 | 0.6 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.1 | 0.4 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
0.1 | 0.2 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
0.0 | 0.8 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
0.0 | 2.6 | GO:0008347 | glial cell migration(GO:0008347) |
0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.0 | 0.5 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
0.0 | 2.0 | GO:0060612 | adipose tissue development(GO:0060612) |
0.0 | 6.2 | GO:0050807 | regulation of synapse organization(GO:0050807) |
0.0 | 0.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.0 | 0.3 | GO:0030035 | microspike assembly(GO:0030035) |
0.0 | 0.4 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.0 | 0.7 | GO:0010842 | retina layer formation(GO:0010842) |
0.0 | 0.2 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
0.0 | 0.1 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
0.0 | 0.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.0 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
0.0 | 0.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.0 | 0.1 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
0.0 | 0.4 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.0 | 0.3 | GO:0030953 | astral microtubule organization(GO:0030953) |
0.0 | 0.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.0 | 0.3 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
0.0 | 0.3 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.0 | 0.1 | GO:0034312 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
0.0 | 0.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
0.0 | 0.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.0 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.0 | 0.5 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 10.3 | GO:0043083 | synaptic cleft(GO:0043083) |
0.6 | 21.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.5 | 19.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.2 | 4.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 1.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 0.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 1.6 | GO:0071564 | npBAF complex(GO:0071564) |
0.1 | 6.1 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.1 | 0.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
0.0 | 0.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.0 | 1.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.2 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 2.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 0.6 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.1 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 0.8 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 0.1 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.0 | 0.1 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.5 | 22.3 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
1.5 | 10.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.9 | 2.8 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
0.6 | 1.7 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.5 | 19.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.4 | 1.2 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.4 | 1.8 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.3 | 4.0 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
0.3 | 8.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.3 | 1.0 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
0.3 | 9.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.2 | 1.9 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
0.2 | 0.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.2 | 0.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.2 | 3.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 0.5 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 0.6 | GO:0070728 | leucine binding(GO:0070728) |
0.1 | 0.6 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.1 | 0.3 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.1 | 1.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 0.2 | GO:0036033 | mediator complex binding(GO:0036033) |
0.1 | 1.4 | GO:0005112 | Notch binding(GO:0005112) |
0.1 | 1.6 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 1.1 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 1.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.2 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.0 | 1.4 | GO:0008748 | N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693) |
0.0 | 0.2 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.7 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.1 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
0.0 | 0.4 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
0.0 | 0.0 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) |
0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
0.0 | 0.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
0.0 | 0.3 | GO:0070628 | proteasome binding(GO:0070628) ubiquitin-specific protease binding(GO:1990381) |
0.0 | 1.6 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 0.0 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.4 | GO:0005504 | fatty acid binding(GO:0005504) |