Motif ID: Foxa2_Foxa1

Z-value: 0.749

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148046896_148046991,
mm10_v2_chr2_-_148045891_148045948		0.146.4e-01Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.097.6e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_97777606 2.267 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr6_+_14901344 1.782 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr14_+_73237891 1.560 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr9_+_53850243 1.527 ENSMUST00000048485.5
 Sln
sarcolipin
chr1_+_12718496 1.458 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr15_-_12592556 1.248 ENSMUST00000075317.5
 Pdzd2
PDZ domain containing 2
chr11_-_33147400 1.178 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr19_-_19111181 1.080 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr6_+_8520008 1.078 ENSMUST00000162567.1
ENSMUST00000161217.1
 Glcci1

glucocorticoid induced transcript 1

chr18_-_47333311 0.923 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr10_+_99263224 0.908 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr15_-_84855093 0.869 ENSMUST00000016768.5
 Phf21b
PHD finger protein 21B
chr4_-_58499398 0.844 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr18_-_62756275 0.834 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr2_+_52072823 0.832 ENSMUST00000112693.2
ENSMUST00000069794.5
 Rif1

Rap1 interacting factor 1 homolog (yeast)

chr19_+_38264761 0.806 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr11_+_29463735 0.799 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr13_-_60177357 0.718 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr10_-_93311073 0.690 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr10_-_93310963 0.660 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0060074 synapse maturation(GO:0060074)
0.2 2.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 1.5 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.4 1.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 1.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 1.2 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 1.2 GO:0060539 diaphragm development(GO:0060539)
0.2 1.1 GO:0046549 retinal cone cell development(GO:0046549)
0.3 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.9 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 0.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 0.8 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 0.7 GO:0042473 outer ear morphogenesis(GO:0042473)
0.1 0.7 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.2 0.6 GO:0060023 soft palate development(GO:0060023)
0.2 0.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.8 GO:0001940 male pronucleus(GO:0001940)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.6 GO:0030478 actin cap(GO:0030478)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.4 1.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 1.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.5 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.5 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.5 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.3 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)