Motif ID: Twist1

Z-value: 0.813


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.097.7e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Showing 1 to 20 of 108 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_112146187 3.630 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr7_-_75308373 2.556 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr9_+_118478851 1.948 ENSMUST00000150633.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chrX_-_166585679 1.603 ENSMUST00000000412.2
 Egfl6
EGF-like-domain, multiple 6
chr6_-_95718800 1.247 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr13_+_104109737 0.998 ENSMUST00000044385.7
 Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr13_+_104109752 0.947 ENSMUST00000160322.1
ENSMUST00000159574.1
 Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr2_+_49787675 0.919 ENSMUST00000028103.6
 Lypd6b
LY6/PLAUR domain containing 6B
chr19_+_25610533 0.819 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr1_-_119053339 0.790 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr11_-_68927049 0.778 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr19_+_5740885 0.772 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr7_+_45216671 0.768 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr11_+_94741782 0.729 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr10_-_127030813 0.724 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr4_-_135494615 0.690 ENSMUST00000102549.3
 Nipal3
NIPA-like domain containing 3
chr6_+_85187438 0.637 ENSMUST00000045942.8
 Emx1
empty spiracles homeobox 1
chr10_+_61175206 0.617 ENSMUST00000079235.5
 Tbata
thymus, brain and testes associated
chr9_-_114844090 0.593 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr9_+_60794468 0.565 ENSMUST00000050183.6
 Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 GO:0048484 enteric nervous system development(GO:0048484)
0.0 2.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.6 1.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 1.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 1.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 1.0 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.9 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.1 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.3 0.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 0.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.8 GO:0021508 floor plate formation(GO:0021508) spinal cord ventral commissure morphogenesis(GO:0021965) floor plate morphogenesis(GO:0033505)
0.0 0.8 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 0.7 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 0.4 GO:0003096 renal sodium ion transport(GO:0003096)
0.1 0.4 GO:0060023 soft palate development(GO:0060023)
0.1 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.4 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.6 GO:0043195 terminal bouton(GO:0043195)
0.0 2.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.2 1.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.9 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.8 GO:0031512 motile primary cilium(GO:0031512)
0.1 0.6 GO:0043293 apoptosome(GO:0043293)
0.2 0.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.3 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular_function category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.2 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.1 1.0 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0005536 glucose binding(GO:0005536)
0.0 0.3 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.1 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0001972 retinoic acid binding(GO:0001972)